L-Ornithine monohydrochloride - 10mM in Water , CAS No.3184-13-2

CAS: 3184-13-2 Cat. No.: L423300 Molecular Weight: 168.62 Beilstein Registry Number: 4420 EC Number: 221-678-6

GRADE & PURITY 10mM in Water

Synonyms

L-(+)-Ornithine Monohydrochloride | L-Ornithine (hydrochloride) | L-Ornithine monohydrochloride, p.a., 98.5% | L-(+)-omithine hydrochloride | L-Ornithine monohydrochloride, BioXtra, >=99% | L-Ornithine, monohydrochloride (9CI); Ornithine, monohydrochlorid

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

L-Ornithine Hydrochloride is a nonprotein amino acid. It is used in the body in the biosynthesis of L-arginine, L-proline and polyamines.Product of arginine degradation by arginase 。 Soluble in water (543 mg/ml at 20 °C), and alcohol. Optical Activity: α20/D +23.0o±0.5o, c = 5 in 5 M HCl; α20/D +23.5o±1.5o, c = 4 in 6 mol/L HCl; α24/D +23.6o, c = 4 in 6 M HCl; α25/D +22.5o±0.7o, c = 2 in 5 M HCl IC50: mGluR-2: EC5050 = 35 μM (human); mGluR-2: EC5050 = 35 μM (rat); mGluR-6: EC5050 = 140 μM (rat); mGluR-6: EC5050 = 140 μM (human); mGluR-5: EC5050 >1 mM (rat) Ki Data: mGluR-2: Ki= 35 μM (human); mGluR-6: Ki= 140 μM (human); mGluR-5: Ki>1 mM (human); mGluR-1a: Ki>1 mM (human); mGluR-4: Ki>3 mM (human)
A nonprotein amino acid used in the biosynthesis of L-arginine, L-proline and polyamines.

Specifications

Synonyms

L-(+)-Ornithine Monohydrochloride | L-Ornithine (hydrochloride) | L-Ornithine monohydrochloride, p.a., 98.5% | L-(+)-omithine hydrochloride | L-Ornithine monohydrochloride, BioXtra, >=99% | L-Ornithine, monohydrochloride (9CI); Ornithine, monohydrochlorid

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle.Nonproteinogenic amino acid. Intermediate metabolite in the urea cycle. Necessary for the biosynthesis of L-arginine, L-proline and polya

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: Cl.NCCC[C@H](N)C(O)=O
• IUPAC Name: (2S)-2,5-diaminopentanoic acid;hydrochloride
• InChIKey: GGTYBZJRPHEQDG-WCCKRBBISA-N
• INCHI: 1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• Isomeric SMILES: C(C[C@@H](C(=O)O)N)CN.Cl
• RTECS: RM2985000
• Alternate CAS: 70-26-8
• Molecular Weight: 168.62
• Beilstein: 4420
• Reaxy-Rn: 4328590
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4328590&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Fatty acids and conjugates Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Fatty acid - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Hydrocarbon derivative - Organic oxygen compound - Hydrochloride - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Organopnictogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Hygroscopic
• Refractive Index: 1.52
• Specific Rotation[α]: +22.0 to +25.0 deg(C=4, 6mol/L HCl)
• Boil Point(°C): 308.7 °C
• Melt Point(°C): 245℃
• Molecular Weight: 168.620 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 168.067 Da
• Monoisotopic Mass: 168.067 Da
• Topological Polar Surface Area: 89.300 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 95.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

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2. Chengyi Xie, Liancheng Gu, Qidi Wu, Lei Li, Chenlu Wang, Jiancheng Yu, Keqi Tang.  (2020)  Effective Chiral Discrimination of Amino Acids through Oligosaccharide Incorporation by Trapped Ion Mobility Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:33226780] [10.1021/acs.analchem.0c03461]

3. Lili Zhang, Wen Duan, Yan Huang, Yuyu Zhang, Baoguo Sun, Dandan Pu, Yizhuang Tang, Chao Liu.  (2020)  Sensory taste properties of chicken (Hy-Line brown) soup as prepared with five different parts of the chicken.  INTERNATIONAL JOURNAL OF FOOD PROPERTIES,      [PMID:] [10.1080/10942912.2020.1828455]

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5. Yuling Li, Bowen Zhou, Keke Wang, Jing Zhang, Wenjian Sun, Li Zhang, Yinlong Guo.  (2021)  Powerful Steroid-Based Chiral Selector for High-Throughput Enantiomeric Separation of α-Amino Acids Utilizing Ion Mobility–Mass Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:34597017] [10.1021/acs.analchem.1c02691]

6. Yifan Zhang, Youwei Zhu, Na Zhao, Jinhui Wu, Yiqiao Hu.  (2015)  Application of isothermal titration calorimeter for screening bitterness-suppressing molecules of quinine.  FOOD CHEMISTRY,      [PMID:26213068] [10.1016/j.foodchem.2015.06.070]