Lidocaine Hydrochloride Monohydrate - Moligand™, ≥98% , Sodium channel alpha subunit blocker, CAS No.6108-05-0, Sodium channel alpha subunit blocker

CAS: 6108-05-0 Cat. No.: L137296 Molecular Weight: 288.81 EC Number: 612-079-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

2',6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE, HYDRATE | LIDOCAINE HYDROCHLORIDE [USP-RS] | 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate | BCP13499 | LIDOCAINE HYDROCHLORIDE [GREEN BOOK] | LIDOCAINE HYDROCHLORIDE [VANDF]

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview

A fast voltage-gated sodium channel blocker

Specifications

Synonyms

2', 6'-ACETOXYLIDIDE, 2-(DIETHYLAMINO)-, HYDROCHLORIDE, HYDRATE | LIDOCAINE HYDROCHLORIDE [USP-RS] | 2-(Diethylamino)-N-(2, 6-dimethylphenyl)acetamide hydrochloride hydrate | BCP13499 | LIDOCAINE HYDROCHLORIDE [GREEN BOOK] | LIDOCAINE HYDROCHLORIDE [VANDF]

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Lidocaine hydrochloride monohydrate is an antiarrhythmic and local anesthetic. It is mostly metabolized in the liver by Cytochrome P450 1A to the pharmacologically-active metabolites glycinexylidide and monoethylglycinexylidide. It is known to block the f

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

BLOCKER

Mechanism of action

Sodium channel alpha subunit blocker

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504768403
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768403
• Canonical Smiles: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.O.Cl
• IUPAC Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrate;hydrochloride
• InChIKey: YECIFGHRMFEPJK-UHFFFAOYSA-N
• INCHI: 1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
• Isomeric SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.O.Cl
• WGK Germany: 3
• RTECS: AN7700000
• Molecular Weight: 288.81
• Reaxy-Rn: 18845016
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18845016&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acid amides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acid amides
• Alternative Parents: Anilides m-Xylenes N-arylamides Trialkylamines Secondary carboxylic acid amides Organopnictogen compounds Organic zwitterions Organic oxides Organic chloride salts Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Alpha-amino acid amide - Anilide - M-xylene - Xylene - N-arylamide - Monocyclic benzene moiety - Benzenoid - Carboxamide group - Secondary carboxylic acid amide - Tertiary amine - Tertiary aliphatic amine - Organic nitrogen compound - Organic zwitterion - Organic salt - Organic chloride salt - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
• External Descriptors: hydrate

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
• Sensitivity: Light sensitive; Moisture sensitive
• Molecular Weight: 288.810 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 288.16 Da
• Monoisotopic Mass: 288.16 Da
• Topological Polar Surface Area: 33.300 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 228.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Ayesha Younas, Zhuolin Dong, Ziye Hou, Muhammad Asad, Mengru Li, Nan Zhang.  (2023)  A chitosan/fucoidan nanoparticle-loaded pullulan microneedle patch for differential drug release to promote wound healing.  CARBOHYDRATE POLYMERS,      [PMID:36746584] [10.1016/j.carbpol.2023.120593]

2. Leixia Mei, Haihong Yang, Weimiao Dong, Min Liu, Jun Han.  (2024)  Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.3c04523]