Sodium channel protein type 8 subunit alpha (SCN8A)

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  1. PF 04885614, Inhibitor of K v11.1;Inhibitor of Na v1.6;Inhibitor of Na v1.8
    CAS: 1480833-70-2 PubChem CID: 65459349 Formula: C13H14F3N3O Molecular Weight: 285.26
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    In Stock Item #: P288823
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    IUPAC Name
    2-[5-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl]propan-2-amine
    SMILES
    CC(C)(C1=NC=C(N1)C2=CC=C(C=C2)OC(F)(F)F)N
    InChIKey
    AGORGFNWYAUYSU-UHFFFAOYSA-N
    InChI
    1S/C13H14F3N3O/c1-12(2,17)11-18-7-10(19-11)8-3-5-9(6-4-8)20-13(14,15)16/h3-7H,17H2,1-2H3,(H,18,19)
    Synonyms
    1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine
  2. DS-1971a, Inhibitor of Na v1.7
    CAS: 1450595-86-4 PubChem CID: 71711862 Formula: C20H21ClFN5O3S Molecular Weight: 465.93
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: D412696
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    5-chloro-2-fluoro-4-[(1S,2R)-2-(2-methylpyrazol-3-yl)cyclohexyl]oxy-N-pyrimidin-4-ylbenzenesulfonamide
    SMILES
    CN1C(=CC=N1)C2CCCCC2OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=NC=C4)F
    InChIKey
    OJKONCJPCULNOW-DYVFJYSZSA-N
    InChI
    1S/C20H21ClFN5O3S/c1-27-16(6-9-25-27)13-4-2-3-5-17(13)30-18-11-15(22)19(10-14(18)21)31(28,29)26-20-7-8-23-12-24-20/h6-13,17H,2-5H2,1H3,(H,23,24,26)/t1show more
    Synonyms
    5-Chloro-2-fluoro-4-{[(1S,2R)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide | US94...
  3. ABBV-318, Channel blocker of Na v1.7;Channel blocker of Na v1.8
    CAS: 1802848-94-7 Formula: C20H15F4N3O2 Molecular Weight: 405.35
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A607321
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    Synonyms
    ABBV318;compound 73
  4. GNE-131, Inhibitor of Na v1.1;Inhibitor of Na v1.2;Inhibitor of Na v1.5;Inhibitor of Na v1.6;Inhibitor of Na v1.7
    CAS: 1629063-81-5 PubChem CID: 91666633 Formula: C23H30N4O3S Molecular Weight: 442.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: G610612
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    IUPAC Name
    N-[7-(1-adamantylmethoxy)-6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl]cyclopropanesulfonamide
    SMILES
    C1CC1C2=CN3C(=NN=C3NS(=O)(=O)C4CC4)C=C2OCC56CC7CC(C5)CC(C7)C6
    InChIKey
    FPERPEQIXLOVIK-UHFFFAOYSA-N
    InChI
    1S/C23H30N4O3S/c28-31(29,18-3-4-18)26-22-25-24-21-8-20(19(12-27(21)22)17-1-2-17)30-13-23-9-14-5-15(10-23)7-16(6-14)11-23/h8,12,14-18H,1-7,9-11,13H2,(Hshow more
    Synonyms
    compound 13;GNE 131;GNE131
  5. GNE-131, Inhibitor of Na v1.1;Inhibitor of Na v1.2;Inhibitor of Na v1.5;Inhibitor of Na v1.6;Inhibitor of Na v1.7
    CAS: 1629063-81-5 PubChem CID: 91666633 Formula: C23H30N4O3S Molecular Weight: 442.57
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    Out of Stock Item #: G654724
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  6. Funapide
    CAS: 1259933-16-8 EC Number: 810-417-7 PubChem CID: 49836093 Formula: C22H14F3NO5 Molecular Weight: 429.35
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    Out of Stock Item #: F650183
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    (7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one | XEN402 | X...
  7. AM-2099
    CAS: 1443373-17-8 PubChem CID: 86687532 Formula: C19H13F3N4O3S2 Molecular Weight: 466.46
    Out of Stock Item #: A651904
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    IUPAC Name
    4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide
    SMILES
    COC1=C(C=CC(=C1)C(F)(F)F)C2=NC=NC3=C2C=CC(=C3)S(=O)(=O)NC4=NC=CS4
    InChIKey
    VSUDRCZPHWUXEW-UHFFFAOYSA-N
    InChI
    1S/C19H13F3N4O3S2/c1-29-16-8-11(19(20,21)22)2-4-14(16)17-13-5-3-12(9-15(13)24-10-25-17)31(27,28)26-18-23-6-7-30-18/h2-10H,1H3,(H,23,26)
  8. Nav1.7-IN-3
    CAS: 1788872-06-9 PubChem CID: 118112300 Formula: C17H20ClFN4O2S2 Molecular Weight: 430.95
    Out of Stock Item #: N649481
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    IUPAC Name
    5-chloro-2-fluoro-4-(1,2,3,5,6,7-hexahydropyrrolizin-8-ylmethylamino)-N-(1,3-thiazol-2-yl)benzenesulfonamide
    SMILES
    C1CC2(CCCN2C1)CNC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=CS4)F
    InChIKey
    XFWKBJBSEOZBRA-UHFFFAOYSA-N
    InChI
    1S/C17H20ClFN4O2S2/c18-12-9-15(27(24,25)22-16-20-5-8-26-16)13(19)10-14(12)21-11-17-3-1-6-23(17)7-2-4-17/h5,8-10,21H,1-4,6-7,11H2,(H,20,22)
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