SF3B1

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  1. Pladienolide B
    CAS: 445493-23-2 Formula: C30H48O8 Molecular Weight: 536.70
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥95%(HPLC)
    ◐ .Made to order · 8–12 wks Item #: P288899
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    IUPAC Name
    [(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-2-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3S)-3-hydroxypentan-2-yl]oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-3,7-dimethyl-1show more
    SMILES
    CCC(C(C)C1C(O1)CC(C)C=CC=C(C)C2C(C=CC(C(CCC(CC(=O)O2)O)(C)O)OC(=O)C)C)O
    InChIKey
    SDOUORKJIJYJNW-QHOUZYGJSA-N
    InChI
    1S/C30H48O8/c1-8-24(33)21(5)29-25(37-29)16-18(2)10-9-11-19(3)28-20(4)12-13-26(36-22(6)31)30(7,35)15-14-23(32)17-27(34)38-28/h9-13,18,20-21,23-26,28-29show more
    Synonyms
    [(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-2-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3S)-3-hydroxypentan-2-yl]oxiran-2-yl]-6-methylhe...
  2. PROTAC-O4I2
    CAS: 2785323-62-6 Formula: C29H29ClN6O5S Molecular Weight: 609.10
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Made to order · 8–12 wks Item #: P659266
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  3. H3B-8800
    CAS: 1825302-42-8 PubChem CID: 92135969 Formula: C31H45N3O6 Molecular Weight: 555.7
    ◐ .Made to order · 8–12 wks Item #: H669620
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    IUPAC Name
    [(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-[(2E,4E,6R)-6-pyridin-2-ylhepta-2,4-dien-2-yl]-1-oxacyclododec-4-en-6-yl] 4-methylpiperazinshow more
    SMILES
    CN1CCN(CC1)C(=O)O[C@@H]2[C@@](O)(C)CC[C@@H](O)CC(=O)O[C@H](C(/C)=C/C=C/[C@@H](C)C3N=CC=CC=3)[C@@H](C)\C=C\2
    InChIKey
    YOIQWBAHJZGRFW-WVRLKXNASA-N
    InChI
    1S/C31H45N3O6/c1-22(26-11-6-7-16-32-26)9-8-10-23(2)29-24(3)12-13-27(39-30(37)34-19-17-33(5)18-20-34)31(4,38)15-14-25(35)21-28(36)40-29/h6-13,16,22,24-show more
  4. Spliceostatin A
    CAS: 391611-36-2 Formula: C28H43NO8 Molecular Weight: 521.600
    ◐ .Made to order · 8–12 wks Item #: S952078
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    IUPAC Name
    [(Z,2S)-5-[[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4-hydroxy-7-methoxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethshow more
    SMILES
    C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@@](O2)(C)OC)CO3)O)C)NC(=O)/C=C\[C@H](C)OC(=O)C
    InChIKey
    XKSGIJNRMWHQIQ-CGPJBNNXSA-N
    InChI
    1S/C28H43NO8/c1-17(9-12-24-26(32)28(16-34-28)15-27(6,33-7)37-24)8-11-23-18(2)14-22(20(4)36-23)29-25(31)13-10-19(3)35-21(5)30/h8-10,12-13,18-20,22-24,2show more
  5. H3B-8800
    CAS: 1825302-42-8 PubChem CID: 92135969 Formula: C31H45N3O6 Molecular Weight: 555.7
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: H1494513
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Frequently Asked Questions

How is the SF3B1 listing put together?
It draws on reported SF3B1 annotations within Epigenetics and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a SF3B1 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the SF3B1 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for SF3B1 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For SF3B1 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the SF3B1 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of SF3B1 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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