Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.
A Ca2+ channel protein inhibitor and MOR activator.
| Pubchem Sid | 488184655 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184655 |
| Canonical Smiles | CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl |
| IUPAC Name | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride |
| InChIKey | PGYPOBZJRVSMDS-UHFFFAOYSA-N |
| INCHI | 1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H |
| Isomeric SMILES | CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl |
| WGK Germany | 3 |
| RTECS | TM4960000 |
| Molecular Weight | 513.5 |
| Reaxy-Rn | 4087090 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4087090&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Diphenylmethanes |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Diphenylmethanes |
| Alternative Parents | Phenylpiperidines Phenylacetamides Aralkylamines Chlorobenzenes Aryl chlorides N-acyl amines Tertiary carboxylic acid amides Tertiary alcohols Trialkylamines Amino acids and derivatives Azacyclic compounds Organochlorides Organic oxides Hydrochlorides Hydrocarbon derivatives Carbonyl compounds Organopnictogen compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Diphenylmethane - Phenylpiperidine - Phenylacetamide - Chlorobenzene - Halobenzene - Aralkylamine - Aryl chloride - Aryl halide - N-acyl-amine - Piperidine - Tertiary carboxylic acid amide - Tertiary alcohol - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Tertiary amine - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Organohalogen compound - Organic nitrogen compound - Hydrochloride - Amine - Hydrocarbon derivative - Alcohol - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organochloride - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. |
| External Descriptors | hydrochloride |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | May 11, 2026 | L129465 | |
| Certificate of Analysis | Mar 11, 2026 | L129465 | |
| Certificate of Analysis | Mar 11, 2026 | L129465 | |
| Certificate of Analysis | Mar 11, 2026 | L129465 | |
| Certificate of Analysis | Jun 10, 2025 | L129465 | |
| Certificate of Analysis | Feb 19, 2025 | L129465 | |
| Certificate of Analysis | Feb 19, 2025 | L129465 | |
| Certificate of Analysis | Feb 14, 2025 | L129465 | |
| Certificate of Analysis | Feb 14, 2025 | L129465 | |
| Certificate of Analysis | Feb 14, 2025 | L129465 | |
| Certificate of Analysis | Oct 31, 2024 | L129465 | |
| Certificate of Analysis | Oct 26, 2024 | L129465 | |
| Certificate of Analysis | Feb 03, 2023 | L129465 | |
| Certificate of Analysis | Jun 29, 2022 | L129465 | |
| Certificate of Analysis | Jun 19, 2021 | L129465 | |
| Certificate of Analysis | Jun 19, 2021 | L129465 | |
| Certificate of Analysis | Jun 19, 2021 | L129465 |
| Solubility | Soluble in methanol, ethanol, DMSO, and chloroform. |
|---|---|
| Sensitivity | moisture sensitive |
| Melt Point(°C) | 223°C |
| Molecular Weight | 513.500 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 7 |
| Exact Mass | 512.2 Da |
| Monoisotopic Mass | 512.2 Da |
| Topological Polar Surface Area | 43.800 Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 623.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| 1. Xiao-yan Chang, Yuan-yuan Liu, Meng-meng Hu, You-qian Liu, Cui-hua Jiang, Qi Wang, Qiao-mei Jin, Dong-jian Zhang, Zhi-qi Yin, Jian Zhang. (2022) Comparative effects of different enzymatic hydrolysates of konjac glucomannan on gut flora and constipation in rats. Food & Function, 13 (16): (8717-8729). [PMID:35916206] [10.1039/D2FO01144A] |
| 2. Tian Li, Mengmeng Hu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Jianwei Xia, Mengqi Miao, Gaofeng Shi, Hui Li, Jian Zhang, Zhiqi Yin. (2020) Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:32980482] [10.1016/j.jep.2020.113411] |
| 3. Jiayi Ma, Yan Su, Jingru Xie, Lin Tao, Yan Zhao, Xiaoxia Wang, Zhenying Kuang, Xianjie Sheng, An Kang, Jiye Aa, Guangji Wang. (2024) Chemometric-based analysis and bioassay guided identification of potent compounds with intestinal motility promoting effects from Dalitong Granules. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:39236779] [10.1016/j.jep.2024.118777] |
| 4. Jingyu Gao, Fan Wu, Mingzhu Yan, Xuejiang Wang, Yan Chi, Yu Zhang, Yu Peng, Mo Li, Yuanying Ni, Xin Wen. (2024) Effects of brown seaweed oligosaccharides on obesity and constipation managements. JOURNAL OF FOOD SCIENCE, 90 (1): (e17647). [PMID:39736091] [10.1111/1750-3841.17647] |
| 5. Liao Yiqi, Wang Yanfang, Huang Weirui, Wang Junxiang, Guo Mu, Zhang Jiahui, Zheng Hanlu, Yan Yingxue, Lin Zhaolong, Qiu Nengfu, Yu Xiangbin, Yu Yue. (2024) L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Scientific Reports, 14 (1): (1-13). [PMID:39256411] [10.1038/s41598-024-71945-8] |
| 6. Dandan Li, Haodong Yan, Junjuan Yu, Yujun Huang, Lina Pan, Wenli Kang, Rongxue Tang, Jiaqi Wang, Hengxian Qu, Yunchao Wa, Xia Chen, Ruixia Gu, Chenchen Zhang. (2024) Probiotic effects of human milk-derived Lactiplantibacillus plantarum M660 on mice with antibiotic-associated diarrhoea and constipation. INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY, [PMID:] [10.1111/1471-0307.13159] |
| 7. Huaxian Chen, Xingyang Wan, Qiulan He, Guozhong Xiao, Yihui Zheng, Minyi Luo, Chaoxin Yang, Donglin Ren, Li Lu, Hui Peng, Hongcheng Lin. (2024) Single-cell RNA sequencing reveals cellular dynamics and therapeutic effects of astragaloside IV in slow transit constipation. Biomolecules and Biomedicine, [PMID:38289380] [10.17305/bb.2024.10187] |
| 8. Zhiqin Liu, Yufeng Xu, Wei Liu, Lin Wang, Zhen Dong, Jianguo Zeng. (2025) Macleaya cordata protopine total alkaloids as potential treatment for diarrhoea: Mechanistic insights and target identification. RESEARCH IN VETERINARY SCIENCE, [PMID:40184723] [10.1016/j.rvsc.2025.105633] |
| 9. Junnan Wu, Qilei Xin, Shuo Wang, Xu Zhang, Chunping Jiang. (2025) Aqueous extracts of Elsholtzia ciliata and Hovenia dulcis ameliorate loperamide-induced constipation in mice by promoting intestinal peristalsis and barrier function and the abundance of intestinal beneficial bacteria. Frontiers in Microbiology, [PMID:40432966] [10.3389/fmicb.2025.1531232] |
| 10. Yun Wang, Simin Zheng, Hao Zheng, Yangru Huang, Bowen Liang, Yingfei Gong, Jinhai Shen, Wenrui Liu, Xiaona Xu, Yuliang Ma, Zhen Liu. (2026) L-arabinose attenuates loperamide-induced constipation through regulation of gut microbiota in mice. Food & Function, [PMID:41699997] [10.1039/D4FO03554B] |
| 11. Yangyang Zhang, Xia Cao, Zong Hou, Zhiqiang Liu, Shu Liu. (2026) Dual benefits of Xiao Chai Hu Tang and its active compounds in CPT-11 therapy: intestinal protection via barrier restoration and anti-inflammation combined with enhanced tumor apoptosis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:] [10.1016/j.jep.2026.121621] |
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