Lovastatin (MK-803) - Moligand™, 10mM in DMSO , CAS No.75330-75-5

CAS: 75330-75-5 Cat. No.: L408097 Molecular Weight: 404.54 EC Number: 692-955-0

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Mevinolin | (2S)​-2-​methyl-butanoic acid (1S,​3R,​7S,​8S,​8aR)​-​1,​2,​3,​7,​8,​8a-​hexahydro-​3,​7-​dimethyl-​8-​[2-​[(2R,​4R)​-​tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl]​ethyl]​-​1-​naphthalenyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Lovastatin (MK-803) Lovastatin (MK-803, Mevinolin) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy .
In vitro

Lovastatin inhibits LPS- and cytokine-mediated production of NO and expression of iNOS in rat primary astrocytes. Lovastatin inhibits LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in rat primary astrocytes, microglia, and macrophages. Lovastatin results in over 95% inhibition of DNA synthesis as measured by incorporation of [3H]thymidine into DNA. Lovastatin synchronizes cells in the G1 and not in the G0 phase of the cell cycle. Lovastatin has a similar growth-inhibitory activity against ras-dependent as well as ras-independent cell lines. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglyc- erides, and a small increase in HDL cholesterol. Lovastatin arrests cells by inhibiting the proteasome, which results in the accumulation of p21 and p27, leading to G1 arrest. Lovastatin is an inhibitor of hydroxymethyl glutaryl (HMG)-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Lovastatin can be used to arrest cultured cells in the G1 phase of the cell cycle, resulting in the stabilization of the cyclin-dependent kinase inhibitors (CKIs) p21 and p27. Lovastatin (2-10 mM) arrests cells in G1 and also prolonged--or arrested a minor fraction of cells in--the G2 phase of the cell cycle in human bladder carcinoma T24 cell line expressing activated p21ras. Lovastatin (50 mM) is cytotoxic in human bladder carcinoma T24 cell line expressing activated p21ras.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Mevinolin | (2S)​-2-​methyl-butanoic acid (1S, ​3R, ​7S, ​8S, ​8aR)​-​1, ​2, ​3, ​7, ​8, ​8a-​hexahydro-​3, ​7-​dimethyl-​8-​[2-​[(2R, ​4R)​-​tetrahydro-​4-​hydroxy-​6-​oxo-​2H-​pyran-​2-​yl]​ethyl]​-​1-​naphthalenyl ester

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Lovastatin (MK-803, Mevinolin) is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidemic agent). Lovastatin triggers autophagy.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• ALogP: 4.3

Names and Identifiers

• Isomeric SMILES: CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C
• WGK Germany: 3
• RTECS: EK7907000
• Molecular Weight: 404.54
• Reaxy-Rn: 14572691
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14572691&ln=

Associated Targets(Human)

HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase (23 Activities)

Discover Target: HMGCR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Specific Rotation[α]: 320 ° (C=0.5, CH3CN)
• Melt Point(°C): 175°C

References

1. Yuan-yuan Zhai, Qiang Wang, Qi-yao Nong, Mei-yu Gao, Ying Zhang, Qin-wen Xiao, Yuan Tian, Zun-jian Zhang, Feng-guo Xu, Pei Zhang.  (2025)  Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40684995] [10.1016/j.bcp.2025.117183]

2. Li Haihua, Li Jiahe, Liu Ningjin, Li Huishan, Wang Jiarui, Zhang Rulan, Xue Jingyan, Kang Xiaotian, Guan Xinying, Lin Shiya, Zhang Ziyu, Kuang Jiaqi, Qian Chenlei, Zhou Pengfei.  (2025)  Synergistic enhancement of alkaloid biosynthesis in Catharanthus roseus CMCs via enzyme Inhibition and abiotic elicitation.  PLANT CELL TISSUE AND ORGAN CULTURE,  162  (3): (1-12).  [PMID:] [10.1007/s11240-025-03211-2]

3. Mengdi Zhang, Zhaoxin Wang, Siyu Hao, Lei Hao, Xinying Zhang, Peng Yu, Hua Sun.  (2020)  Synthesis of natural 3′-Prenylchalconaringenin and biological evaluation of ameliorating non-alcoholic fatty liver disease and metabolic syndrome.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:32791402] [10.1016/j.ejmech.2020.112649]

4. Gai Gao, Jie Zhao, Jing Ding, Shuyan Liu, Yanyan Shen, Changxin Liu, Huifen Ma, Yu Fu, Jiangyan Xu, Yiran Sun, Xiaowei Zhang, Zhenqiang Zhang, Zhishen Xie.  (2023)  Alisol B regulates AMPK/mTOR/SREBPs via directly targeting VDAC1 to alleviate hyperlipidemia.  PHYTOMEDICINE,      [PMID:38520833] [10.1016/j.phymed.2023.155313]

5. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun.  (2023)  Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:37099836] [10.1016/j.ejmech.2023.115391]

6. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang.  (2023)  Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways.  ACS Chemical Neuroscience,      [PMID:36917811] [10.1021/acschemneuro.3c00104]

7. Bo Wei, Yuanfang Li, Meiying Ao, Wenxiang Shao, Kun Wang, Tong Rong, Yun Zhou, Yong Chen.  (2022)  Ganglioside GM3-Functionalized Reconstituted High-Density Lipoprotein (GM3-rHDL) as a Novel Nanocarrier Enhances Antiatherosclerotic Efficacy of Statins in apoE−/− C57BL/6 Mice.  Pharmaceutics,  14  (11): (2534).  [PMID:36432725] [10.3390/pharmaceutics14112534]

8. Qing Sun, Li Li, Quan Zhou.  (2022)  Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats.  Drug Design Development and Therapy,      [PMID:35607596] [10.2147/DDDT.S364234]

9. Pan Zhenzhen, Wang Kai, Wang Xiniao, Jia Zhirong, Yang Yuqi, Duan Yalei, Huang Lianzhan, Wu Zhuo-Xun, Zhang Jian-ye, Ding Xuansheng.  (2022)  Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression.  Molecular Cancer,  21  (1): (1-17).  [PMID:35303882] [10.1186/s12943-022-01547-3]

10. Ping-Ting Xiao, Yu-Jia Kuang, Shi-Yu Liu, Zhi-Shen Xie, Jin-Hua Hao, E-Hu Liu.  (2022)  The antihyperlipidemic equivalent combinatorial components from peel of Citrus reticulata ‘Chachi’.  JOURNAL OF FOOD AND DRUG ANALYSIS,      [PMID:35647727] [10.38212/2224-6614.3388]

11. Bei Yan, Lei Chen, Yanhui Wang, Jiacheng Zhang, Hui Zhao, Qinglian Hua, Shengjie Pei, Zihang Yue, Hui Liang, Huaqi Zhang.  (2022)  Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:35227062] [10.1021/acs.jafc.1c07733]

12. Zhishen Xie, Er-wen Li, Gai Gao, Yueyue Du, Mengyao Wang, Hui Wang, Pan Wang, Yonghui Qiao, Yunfang Su, Jiangyan Xu, Xiaowei Zhang, Zhenqiang Zhang.  (2022)  Zexie Tang targeting FKBP38/mTOR/SREBPs pathway improves hyperlipidemia.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:35151834] [10.1016/j.jep.2022.115101]

13. Andy Wijaya, Yi Wang, Dan Tang, Yuan Zhong, Boyan Liu, Meng Yan, Quhui Jiu, Wei Wu, Guixue Wang.  (2021)  A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression.  Journal of Materials Chemistry B,  10  (4): (607-624).  [PMID:34994373] [10.1039/D1TB01455B]

14. Longkai Shi, Emad Karrar, Xingguo Wang.  (2021)  Sesamol ameliorates hepatic lipid accumulation and oxidative stress in steatosis HepG2 cells via the PPAR signaling pathway.  JOURNAL OF FOOD BIOCHEMISTRY,  45  (11): (e13976).  [PMID:34664288] [10.1111/jfbc.13976]

15. Hong Zhang, Shaoting Sang, Huimin Xu, Linghua Piao, Xiande Liu.  (2021)  Lovastatin suppresses bacterial therapy-induced neutrophil recruitment to the tumor by promoting neutrophil apoptosis.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2021.104693]

16. Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian.  (2021)  Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.  NEUROCHEMISTRY INTERNATIONAL,      [PMID:34048842] [10.1016/j.neuint.2021.105078]

17. Ping-Ting Xiao, Zhi-Shen Xie, Yu-Jia Kuang, Shi-Yu Liu, Chun Zeng, Ping Li, E-Hu Liu.  (2021)  Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway.  Acta Pharmaceutica Sinica B,      [PMID:34900535] [10.1016/j.apsb.2021.03.031]

18. Na Deng, Ziqian He, Ruixue Guo, Bisheng Zheng, Tong Li, Rui Hai Liu.  (2020)  Highland Barley Whole Grain (Hordeum vulgare L.) Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and AMPK Pathways in Leptin Receptor-Deficient db/db Mice.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:32985184] [10.1021/acs.jafc.0c04780]

19. Xing Zhang, Wen Shi, Hui He, Ruge Cao, Tao Hou.  (2020)  Hypolipidemic effects and mechanisms of Val-Phe-Val-Arg-Asn in C57BL/6J mice and 3T3-L1 cell models.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2020.104100]

20. Guihua Yan, Yunchao Feng, Zhebang Gao, Xianhai Zeng, Wenjing Hong, Wenjie Liu, Yong Sun, Xing Tang, Tingzhou Lei, Lu Lin.  (2019)  Stable and Biocompatible Cellulose-Based CaCO3 Microspheres for Tunable pH-Responsive Drug Delivery.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.9b05144]

21. Kun Wang, Chuan Yu, Yang Liu, Wendiao Zhang, Yanan Sun, Yong Chen.  (2018)  Enhanced Antiatherosclerotic Efficacy of Statin-Loaded Reconstituted High-Density Lipoprotein via Ganglioside GM1 Modification.  ACS Biomaterials Science & Engineering,      [PMID:33418777] [10.1021/acsbiomaterials.7b00871]

22. Yu Zhang, Shiguo Chen, Chaoyang Wei, Jianchu Chen, Xingqian Ye.  (2016)  Proanthocyanidins from Chinese bayberry (Myrica rubra Sieb. et Zucc.) leaves regulate lipid metabolism and glucose consumption by activating AMPK pathway in HepG2 cells.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2016.12.030]

23. Zu-Guo Zheng, Ya-Ping Zhou, Xin Zhang, Pyone Myat Thu, Zhi-Shen Xie, Chong Lu, Tao Pang, Bin Xue, Da-Qian Xu, Yan Chen, Xiao-Wei Chen, Hui-Jun Li, Xiaojun Xu.  (2016)  Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation.  BIOCHEMICAL PHARMACOLOGY,      [PMID:27816546] [10.1016/j.bcp.2016.10.016]

24. Zhi-Shen XIE, Ling-Jun ZHONG, Xiao-Meng WAN, Meng-Ning LI, Hua YANG, Ping LI, Xiao-Jun XU.  (2016)  Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs.  Chinese Journal of Natural Medicines,      [PMID:28236404] [10.1016/S1875-5364(16)30089-9]

25. Junfeng Li, Min Guo, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren.  (2024)  Ameliorative potential of ellagic acid via PPARγ against hyperlipidemia: Insights from mice and zebrafish.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.105582]

26. Jie Zhao, Gai Gao, Jing Ding, Wei Liu, Tao Wang, Liang Zhao, Jiangyan Xu, Zhenqiang Zhang, Xiaowei Zhang, Zhishen Xie.  (2024)  Astragaloside I Promotes Lipophagy and Mitochondrial Biogenesis to Improve Hyperlipidemia by Regulating Akt/mTOR/TFEB Pathway.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:39226078] [10.1021/acs.jafc.4c03172]

27. Qiuyan Jiang, Tiehua Zhang, Yuan Liang, Jie Zhang.  (2024)  Baicalein ameliorates lipid accumulation in HepG2 cells via the pregnane X receptor signaling pathway.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104482]

28. Lin Fu, Hengxin Ren, Chaoxing Wang, Yaxin Zhao, Bohang Zou, Xiangyu Zhang.  (2025)  Formation of PEG-PLGA Microspheres for Controlled Release of Simvastatin and Carvacrol: Enhanced Lipid-Lowering Efficacy and Improved Patient Compliance in Hyperlipidemia Therapy.  Polymers,  17  (5): (574).  [PMID:40076067] [10.3390/polym17050574]

29. Kun Miao, Yawei Zhao, Ning Xue.  (2024)  Gkongensin A, an HSP90β inhibitor, improves hyperlipidemia, hepatic steatosis, and insulin resistance.  Heliyon,      [PMID:38655315] [10.1016/j.heliyon.2024.e29367]

30. Guangjie Zhang, Huiying Zhang, Ruiyi Dong, Hongmei Zhao, Junfeng Li, Weiming Yue, Zheng Ma.  (2024)  Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice.  Food Science & Nutrition,      [PMID:39479652] [10.1002/fsn3.4408]

31. Zijun Tao, Jian Zhang, Fuge Niu, Huien Zhang, Zhongfa Chen, Shanfu Wang, Yuli Zhang, Jie Li, Peng Liu.  (2024)  Polygonati rhizoma fermentation by Monascus ruber and evaluation of fermentation products in vitro.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2024.07.013]

32. Peiyu Xue, Xinyong You, Li Ren, Weiming Yue, Zheng Ma.  (2024)  PPARγ-mediated amelioration of lipid metabolism abnormality by kaempferol.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39278305] [10.1016/j.abb.2024.110154]

33. Qian Hu, Mengyao Wang, Meng Chen, Jinjin Wang, Ting Niu.  (2025)  Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B-Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling.  PHYTOTHERAPY RESEARCH,      [PMID:39949030] [10.1002/ptr.8439]

34. Liu Shu-yan, Zhang Xiao-wei, Gao Gai, Liu Chang-xin, Chen Hui, Fu Zhong-xue, Xu Jiang-yan, Wang Zhen-zhen, Zhang Zhen-qiang, Xie Zhi-shen.  (2025)  Pseudolaric Acid B Alleviates Non-alcoholic Fatty Liver Disease by Targeting PPARα to Regulate Lipid Metabolism and Promote Mitochondrial Biogenesis.  Chinese Journal of Integrative Medicine,      [PMID:40515882] [10.1007/s11655-025-3832-y]

35. Jiaxuan Li, Yu Li, Xunyu Song, Yuxiao Wang, Yinxu Zhang, Xinghua Gao, Mingqian Tan, Wentao Su.  (2025)  Ulva lactuca Extracellular Vesicles Protect Against High-Fat Diet-Induced Intestinal Damage via Nrf2/Keap1/HO-1 Activation.  Food & Function,      [PMID:41355512] [10.1039/D5FO03126E]