Methoxyamine hydrochloride - ≥98% , CAS No.593-56-6

CAS: 593-56-6 Cat. No.: M109434 Molecular Weight: 83.52 Beilstein Registry Number: 3589723 EC Number: 209-798-7

GRADE & PURITY ≥98%

Synonyms

methoxyamine hydrochloride salt | N-Methoxylamine hydrochloride | HY-Y0958 | N-methoxyamine hydrochloride | NSC3801 | NSC-3801 | F2158-1506 | EINECS 209-798-7 | hydroxymethyltransferase inhibitor | methyoxyamine hydrochloride | Z1741976428 | DEUTERO-METHO

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

Reagent for the preparation of O-methyl oximes. Used to make O-methyl oximes from aldehydes or ketones.

Specifications

Synonyms

methoxyamine hydrochloride salt | N-Methoxylamine hydrochloride | HY-Y0958 | N-methoxyamine hydrochloride | NSC3801 | NSC-3801 | F2158-1506 | EINECS 209-798-7 | hydroxymethyltransferase inhibitor | methyoxyamine hydrochloride | Z1741976428 | DEUTERO-METHO

Specifications & Purity

≥98%

Storage

Room temperature, Argon charged

Shipped In

Normal

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488190112
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488190112
• Canonical Smiles: CON.Cl
• IUPAC Name: O-methylhydroxylamine;hydrochloride
• InChIKey: XNXVOSBNFZWHBV-UHFFFAOYSA-N
• INCHI: 1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H
• Isomeric SMILES: CON.Cl
• WGK Germany: 3
• RTECS: NC3980000
• Alternate CAS: 67-62-9
• UN Number: 1759
• Packing Group: I
• Molecular Weight: 83.52
• Beilstein: 3589723
• Reaxy-Rn: 3589723
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3589723&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Organooxygen compounds
• Alternative Parents: Organic nitrogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organooxygen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as organooxygen compounds. These are organic compounds containing a bond between a carbon atom and an oxygen atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water; Slightly soluble in Ethanol; Very slightly soluble in Ether
• Sensitivity: Hygroscopic
• Melt Point(°C): 148-153°C
• Molecular Weight: 83.520 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 83.0138 Da
• Monoisotopic Mass: 83.0138 Da
• Topological Polar Surface Area: 35.300 Ų
• Heavy Atom Count: 4
• Formal Charge: 0
• Complexity: 4.800
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Lei Song, Yating Zhou, Yuxia Zhai, Xiangxiang Huo, Mengying Chen, Hong Shi, Yingli Yu, Yue Zhang, Kun Zhou.  (2023)  Sub-chronic toxicity of an aqueous extract of Epimedium sagittatum (Sieb. Et Zucc.) Maxim. in rats.  DRUG AND CHEMICAL TOXICOLOGY,      [PMID:35287533] [10.1080/01480545.2022.2050749]

2. Ruipeng Lu, Jingjing Hong, Tong Fu, Yu Zhu, Ruiqi Tong, Di Ai, Shuai Wang, Qingsong Huang, Ceshi Chen, Zhiming Zhang, Rui Zhang, Huiling Guo, Boan Li.  (2024)  Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.  Advanced Science,      [PMID:38627980] [10.1002/advs.202308945]

3. Zhang Xiaohan, Zhang Dong, Ding Yan, Li Zilong, Wang Chenchen, Ye Shuhong.  (2023)  Biosynthesis of resveratrol by an endophytic Priestia megaterium PH3 via the phenylpropane pathway.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,      [PMID:37801099] [10.1007/s00253-023-12768-x]

4. Hailing Huang, Bailu Duan, Sili Zheng, Yan Ye, Dongning Zhang, Zhuang Huang, Shanshan Wang, Fengyun Zhang, Ping Huang, Fang Huang, Lintao Han.  (2023)  Integrated network pharmacology and metabolomics analyses of the mechanism underlying the efficacy of Ma-Mu-Ran Antidiarrheal Capsules against dextran sulfate sodium–induced ulcerative colitis.  BIOMEDICAL CHROMATOGRAPHY,  37  (11): (e5732).  [PMID:37732359] [10.1002/bmc.5732]

5. Honghua Zhang, Yunting Sun, Yuqing Zou, Cheng Chen, Shuling Wang.  (2023)  Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:37726069] [10.1016/j.jep.2023.117193]

6. Wenbo Ma, Zhenlong Zhang, Yuefeng Liu, Huiping Gao, Yanli Mao.  (2023)  Highly efficient and stable quasi two-dimensional perovskite solar cells via synergistic effect of dual additives.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:37235937] [10.1016/j.jcis.2023.05.132]

7. Xianxiu Li, Tao He, Yangchen Mao, Jianwei Mao, Xiaojin Lai, Hangjia Tu, Yi Zhou, Ruyi Sha.  (2023)  Changes in Physicochemical Properties, Metabolites and Antioxidant Activity of Edible Grass during Spontaneous Fermentation.  Fermentation-Basel,  9  (4): (377).  [PMID:] [10.3390/fermentation9040377]

8. Pengmeng Du, Honglun Yuan, Yayu Chen, Haihong Zhou, Youjin Zhang, Menglan Huang, Yiding Jiangfang, Rongxiu Su, Qiyu Chen, Jun Lai, Lingliang Guan, Yuanhao Ding, Haiyan Hu, Jie Luo.  (2023)  Identification of Key Aromatic Compounds in Basil (Ocimum L.) Using Sensory Evaluation, Metabolomics and Volatilomics Analysis.  Metabolites,  13  (1): (85).  [PMID:36677010] [10.3390/metabo13010085]

9. Honghua Zhang, Yuqing Zou, Qingjie Xue, Minhui Li, Huimin Yang, Huijuan Cheng, Yuxin Gu, Chenjia Shen, Qingchang Tian, Shuling Wang.  (2022)  Elemene oral emulsion attenuates colitis in mice by altering gut microbiome and regulating amino acids metabolism.  MICROBIAL PATHOGENESIS,      [PMID:36336131] [10.1016/j.micpath.2022.105821]

10. Dongning Zhang, Bailu Duan, Li Sun, Yanfen Duan, Sili Zheng, Jingjing Li, Hailong Yin, Dandan Mu, Shuaihong Hou, Guoyan Mo, Lintao Han, Fang Huang, Qiang Yin.  (2022)  Mechanism of Shiliu Buxue Syrup for anemia using integrated metabolomics and network pharmacology.  ANALYTICAL BIOCHEMISTRY,      [PMID:35690102] [10.1016/j.ab.2022.114774]

11. Zhouxian Li, Qi Wang, Keyun Wang, Weibing Zhang, Mingliang Ye.  (2022)  An antibody-free enrichment approach enabled by reductive glutaraldehydation for monomethyllysine proteome analysis.  PROTEOMICS,      [PMID:35532377] [10.1002/pmic.202100378]

12. Xue Liming, Xu Jiale, Feng Chao, Lu Dasheng, Zhou Zhijun.  (2022)  Optimal Normalization Method for GC-MS/MS-Based Large-Scale Targeted Metabolomics.  JOURNAL OF ANALYTICAL CHEMISTRY,  77  (3): (361-368).  [PMID:] [10.1134/S1061934822030054]

13. Xiaoya Tao, Qiong Wu, Suqing Huang, Beiwei Zhu, Feng Chen, Bin Liu, Luyun Cai, Linchun Mao, Zisheng Luo, Li Li, Tiejin Ying.  (2022)  Exogenous abscisic acid regulates primary metabolism in postharvest cherry tomato fruit during ripening.  SCIENTIA HORTICULTURAE,      [PMID:] [10.1016/j.scienta.2022.111008]

14. Guo Mei, Wu Zhicong, An Qi, Li Hengyang, Wang Lei, Zheng Yuguang, Guo Long, Zhang Dan.  (2021)  Comparison of Volatile Oils and Primary Metabolites of Raw and Honey-Processed Ephedrae Herba by GC–MS and Chemometrics.  JOURNAL OF AOAC INTERNATIONAL,  105  (2): (576-586).  [PMID:34626113] [10.1093/jaoacint/qsab139]

15. Shu Lili, Zeng Zhiheng, Dai Jianqing, Cheng Yi, Lu Yuanping, Chen Meiyuan, Zeng Hui.  (2021)  Morphological and metabolic changes in an aged strain of Agaricus bisporus As2796.  APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,  105  (20): (7997-8007).  [PMID:34596723] [10.1007/s00253-021-11526-1]

16. Mi Mi, Zijian Liu, Xin Zheng, Qiuyue Wen, Fang Zhu, Juan Li, Ishanee Devi Mungur, Liling Zhang.  (2021)  Serum metabolomic profiling based on GC/MS helped to discriminate Diffuse Large B-cell Lymphoma patients with different prognosis.  LEUKEMIA RESEARCH,      [PMID:34455197] [10.1016/j.leukres.2021.106693]

17. You Zhou, De-Qiang Qin, Pei-Wen Zhang, Ben-Ju Liu, Xiao-Tian Chen, Zhi-Xiang Zhang.  (2019)  The comparative metabolic response of Bactrocera dorsalis larvae to azadirachtin, pyriproxyfen and tebufenozide.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,      [PMID:31809954] [10.1016/j.ecoenv.2019.110020]

18. Mingjie Deng, Meiling Zhang, Xueli Huang, Jianshe Ma, Lufeng Hu, Guanyang Lin, Xianqin Wang.  (2015)  A gas chromatography–mass spectrometry based study on serum metabolomics in rats chronically poisoned with hydrogen sulfide.  Journal of Forensic and Legal Medicine,      [PMID:25882152] [10.1016/j.jflm.2015.02.014]

19. Xiao-san Li, Yi-chang Ren, Yu-zhou Bao, Jie Liu, Xiao-kun Zhang, You-wei Zhang, Xue-Long Sun, Xin-sheng Yao, Jin-Shan Tang.  (2018)  Synthesis of C3-Neoglycosides of digoxigenin and their anticancer activities.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:29329000] [10.1016/j.ejmech.2017.12.086]

20. Lingping Hu, Yin Zhu, Hongwei Zhang, Xiaomei Zhang, Yujin Li, Qian Yao, Qiang Cai, Yaqin Hu.  (2024)  Differentiation of three commercial tuna species through GC-Q-TOF and UPLC-Q/Orbitrap mass spectrometry-based metabolomics and chemometrics.  FOOD CHEMISTRY,      [PMID:38754166] [10.1016/j.foodchem.2024.139603]

21. Fang Dong, Hongkun Lai, Qifang Sun, Wenjie Yu, Gaowei Zhang, Shijuan Du, Shuai Zhuang, Tao Liu, Yan Li, Xiaoqing Fan, Feng Xie, Liping Luo.  (2025)  Dynamic changes in metabolic compounds and their effects on flavor quality of Fuliang black tea and green tea during processing.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107332]

22. Cai Wen, Zhang Qian-ying, Zhu Peng-cheng, Hu Wanrong, An Hongyue, Huo Dan-Qun, Li Dongliang.  (2025)  Study on dynamic changes and correlations of microbial diversity, key enzyme activity and conventional components in tobacco leaves during the aging process.  Bioresources and Bioprocessing,  12  (1): (1-17).  [PMID:41191230] [10.1186/s40643-025-00969-3]