Mycalolide B - ≥98% , CAS No.122752-21-0

CAS: 122752-21-0 Cat. No.: M329662 Molecular Weight: 1027.16 PubChem CID: 6440825

GRADE & PURITY ≥98%

Synonyms

[(E,3R,4R,5S,6R,9S,10S)-4-Acetyloxy-1-[formyl(methyl)amino]-11-[(10S,11R,13E,16S,20S,21R,22S,24Z)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Mycalolide B has been shown to inhibit actin polymerization (IC|50|=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg|2+|-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 μM, abolished both ADP (10 μM)- and collagen (3 μg/ml)-induced platelet aggregation|in vitro|.

Specifications

Synonyms

[(E, 3R, 4R, 5S, 6R, 9S, 10S)-4-Acetyloxy-1-[formyl(methyl)amino]-11-[(10S, 11R, 13E, 16S, 20S, 21R, 22S, 24Z)-16-hydroxy-10, 22-dimethoxy-11, 21-dimethyl-12, 18-dioxo-3, 7, 19, 27-tetraoxa-29, 30, 31-triazatetracyclo[24.2.1.12, 5.16, 9]hentriaconta-1(28), 2(31), 4, 6(30), 8, 13, 24,

Specifications & Purity

≥98%

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1C(CC=CC2=NC(=CO2)C3=NC(=CO3)C4=NC(=CO4)C(C(C(=O)C=CCC(CC(=O)OC1CC(C(C)CCC(C(C)C(C(C)C=CN(C)C=O)OC(=O)C)OC(=O)C(COC)OC)OC)O)C)OC)OC
• IUPAC Name: [(E,3R,4R,5S,6R,9S,10S)-4-acetyloxy-1-[formyl(methyl)amino]-11-[(10S,11R,13E,16S,20S,21R,22S,24Z)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-1(28),2(31),4,6(30),8,13,24,26(29)-octaen-20-yl]-10-methoxy-3,5,9-trimethylundec-1-en-6-yl] (2R)-2,3-dimethoxypropanoate
• InChIKey: ZYDMLFOHENLMIN-RKRPCCGKSA-N
• INCHI: 1S/C52H74N4O17/c1-30(19-20-42(73-52(62)45(66-11)28-63-8)34(5)48(71-35(6)58)31(2)21-22-56(7)29-57)43(65-10)24-44-33(4)41(64-9)17-14-18-46-53-38(26-68-46)50-55-39(27-70-50)51-54-37(25-69-51)49(67-12)32(3)40(60)16-13-15-36(59)23-47(61)72-44/h13-14,16,18,21-22,25-27,29-34,36,41-45,48-49,59H,15,17,19-20,23-24,28H2,1-12H3/b16-13+,18-14-,22-21+/t30-,31+,32-,33+,34-,36-,41-,42+,43-,44-,45+,48+,49-/m0/s1
• Isomeric SMILES: C[C@@H]1[C@H](C/C=C\C2=NC(=CO2)C3=NC(=CO3)C4=NC(=CO4)[C@H]([C@H](C(=O)/C=C/C[C@@H](CC(=O)O[C@H]1C[C@@H]([C@@H](C)CC[C@H]([C@H](C)[C@@H]([C@H](C)/C=C/N(C)C=O)OC(=O)C)OC(=O)[C@@H](COC)OC)OC)O)C)OC)OC
• PubChem CID: 6440825
• Molecular Weight: 1027.16

Chemical and Physical Properties

• Solubility: Soluble in DMSO, ethanol, methanol, and Isopropanol.
• Sensitivity: Light sensitive
• Refractive Index: n20D1.55 (Predicted)
• Specific Rotation[α]: α20D-53.4, c = 1.3 in chloroform
• Boil Point(°C): ~1042.3° C at 760 mmHg (Predicted)