ONO-2333MS - Moligand™ , Corticotropin releasing factor receptor 1 antagonist, CAS No.O612510, Corticotropin releasing factor receptor 1 antagonist

CAS: O612510 Cat. No.: O612510 PubChem CID: 9801039

GRADE & PURITY Moligand™

Synonyms

UNII-T989JBG788 | ONO2333 | ONO-2333 | 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine | 10-(2-Chloro-4-methoxyphenyl)-11- methyl-N-(pentan-3-yl)-1,8,12-triazatricyclo(7.3.0.03,7)dodeca-2,7,9,1

Storage

Room temperature

Specifications

Synonyms

UNII-T989JBG788 | ONO2333 | ONO-2333 | 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6, 7-dihydro-5H-cyclopenta[d]pyrazolo[1, 5-a]pyrimidine | 10-(2-Chloro-4-methoxyphenyl)-11- methyl-N-(pentan-3-yl)-1, 8, 12-triazatricyclo(7.3.0.03, 7)dodeca-2, 7, 9, 1

Specifications & Purity

Moligand™

Storage

Room temperature

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Corticotropin releasing factor receptor 1 antagonist

Names and Identifiers

• Canonical Smiles: CCC(Nc1c2CCCc2nc2n1nc(c2c1ccc(cc1Cl)OC)C)CC
• InChIKey: LDIOUQIXNSSOGU-UHFFFAOYSA-N
• INCHI: 1S/C22H27ClN4O/c1-5-14(6-2)24-21-17-8-7-9-19(17)25-22-20(13(3)26-27(21)22)16-11-10-15(28-4)12-18(16)23/h10-12,14,24H,5-9H2,1-4H3
• Isomeric SMILES: CCC(CC)NC1=C2CCCC2=NC3=C(C(=NN31)C)C4=C(C=C(C=C4)OC)Cl
• PubChem CID: 9801039

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Azoles
      • Subclass Pyrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Azoles
• Subclass: Pyrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrazoles
• Alternative Parents: Pyrazolo[1,5-a]pyrimidines Phenoxy compounds Methoxybenzenes Anisoles Chlorobenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Aryl chlorides Heteroaromatic compounds Azacyclic compounds Organochlorides Hydrocarbon derivatives Amines
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phenylpyrazole - Pyrazolopyrimidine - Pyrazolo[1,5-a]pyrimidine - Phenol ether - Phenoxy compound - Methoxybenzene - Anisole - Chlorobenzene - Alkyl aryl ether - Halobenzene - Aminopyrimidine - Monocyclic benzene moiety - Benzenoid - Pyrimidine - Aryl chloride - Aryl halide - Heteroaromatic compound - Azacycle - Ether - Organochloride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Organohalogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CRHR1 Tclin Corticotropin-releasing factor receptor 1 (2 Activities)

Discover Target: CRHR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)

Discover Target: CRHR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action