[Phe8Ψ(CH-NH)-Arg9]-Bradykinin, CAS No.118122-39-7

CAS: 118122-39-7 Cat. No.: P287159 Molecular Weight: 1046.23 PubChem CID: 3082903

Specifications

Product Name

[Phe8Ψ(CH-NH)-Arg9]-Bradykinin, CAS No.118122-39-7

Synonyms

(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3

Biochemical and Physiological Mechanisms

Selective bradykinin B2receptor agonist that is resistant to carboxypeptidase cleavage. 5-fold more potent and exhibits a more prolonged duration of action thanbradykinin(Cat No. 3004)in vivo.

Sequence

RPPGFSPFR(Modifications: Phe-8 - Arg-9 peptide bond replaced with Ψ-(CH2-NH))

CAS

118122-39-7

Molecule Type

Peptide

Storage and Shipping

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Phenylalanine and derivatives N-acyl-alpha amino acids and derivatives Proline and derivatives Alpha amino acid amides Amphetamines and derivatives L-alpha-amino acids Pyrrolidinecarboxamides N-acylpyrrolidines Aralkylamines Fatty amides Tertiary carboxylic acid amides Secondary carboxylic acid amides Amino acids Guanidines Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Azacyclic compounds Carboximidamides Carboxylic acids Dialkylamines Primary alcohols Organic oxides Carbonyl compounds Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-oligopeptide - Phenylalanine or derivatives - N-acyl-alpha amino acid or derivatives - Proline or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - L-alpha-amino acid - Amphetamine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid - Pyrrolidine-2-carboxamide - N-acylpyrrolidine - Pyrrolidine carboxylic acid or derivatives - Aralkylamine - Fatty acyl - Monocyclic benzene moiety - Benzenoid - Fatty amide - Pyrrolidine - Tertiary carboxylic acid amide - Guanidine - Secondary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Amino acid - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid - Secondary aliphatic amine - Carboximidamide - Secondary amine - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Amine - Alcohol - Organic nitrogen compound - Primary aliphatic amine - Primary amine - Primary alcohol - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y