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PIM1-IN-1 - ≥99% , CAS No.1417630-95-5
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity
In Vitro
PIM1-IN-1 (Compound 42) exhibits antiproliferative activity, with GI 50 of 1.48 µM for melanoma cell line SKMEL-19. PIM1-IN-1 has significant synergistic effect combined with different antitumoral agents in different tumor cell lines. PIM1-IN-1 (2.5, 5, or 10 µM, 24 hours) induces apoptosis in SKMEL19 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: SKMEL19 cells Concentration: 2.5, 5, or 10 µM Incubation Time: 24 hours Result: Regulated cell cycle, induced cell apopsis in SKMEL19 cells.
In Vivo
PIM1-IN-1 shows cceptable clearance of 1.26 L/h/kg in BALB-C mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:PIM1 7 nM (IC 50 ) PIM3 70 nM (IC 50 ) PIM2 5530 nM (IC 50 )
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no obvious
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥99%
Names and Identifiers
| Molecular Weight | 474.56 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 45 mg/mL (94.82 mM; Need ultrasonic) |
|---|
Solution Calculators
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