Rat ghrelin-28 - Moligand™, ≥95% , Agonist of ghrelin receptor, CAS No.258338-12-4, Agonist of ghrelin receptor

CAS: 258338-12-4 Cat. No.: G111460 Molecular Weight: 3314.8 PubChem CID: 44134734

GRADE & PURITY Moligand™, ≥95%

Synonyms

GHRELIN, RAT | GSSFLSPEHQKAQQRKESKKPPAKLQPR | DTXSID70657540 | LS-15550 | MFCD07366495 | (Ser-3 = Ser(n-octanoyl)) | C147H245N45O42 | Glycylseryl-N-octanoylserylphenylalanylleucylserylprolyl-alpha-glutamylhistidylglutaminyllysylalanylglutaminylglutaminyla

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

The amino acid sequence：Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro- Arg

Specifications

Synonyms

GHRELIN, RAT | GSSFLSPEHQKAQQRKESKKPPAKLQPR | DTXSID70657540 | LS-15550 | MFCD07366495 | (Ser-3 = Ser(n-octanoyl)) | C147H245N45O42 | Glycylseryl-N-octanoylserylphenylalanylleucylserylprolyl-alpha-glutamylhistidylglutaminyllysylalanylglutaminylglutaminyla

Specifications & Purity

Moligand™, ≥95%

Biochemical and Physiological Mechanisms

Endogenous agonist peptide for the ghrelin (GHS) receptor. Stimulates release of growth hormone from the pituitary gland and regulates feeding, growth and energy production.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of ghrelin receptor

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Isomeric SMILES: CCCCCCCC(=O)N(C(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)N2CCCC2C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CCC(=O)N)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)N6CCCC6C(=O)NC(CCCNC(=N)N)C(=O)O)C(=O)C(CO)NC(=O)CN
• PubChem CID: 44134734
• Molecular Weight: 3314.8

Associated Targets(Human)

GHSR Tclin Growth hormone secretagogue receptor type 1 (0 Activities)

Discover Target: GHSR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Gui-Bo Liu, Yong-Xia Cheng, Hua-Min Li, Yong Liu, Li-Xin Sun, Qi Wu, Shang-Fu Guo, Ting-Ting Li, Chuan-Ling Dong, Ge Sun.  (2023)  Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.  Molecular Medicine Reports,  28  (3): (1-14).  [PMID:37449526] [10.3892/mmr.2023.13050]

2. Shi-shi Liao, Le-le Zhang, Yi-guo Zhang, Jie Luo, Tulanisa Kadier, Ke Ding, Rong Chen, Qing-tao Meng.  (2024)  Ghrelin alleviates intestinal ischemia–reperfusion injury by activating the GHSR-1α/Sirt1/FOXO1 pathway.  FASEB JOURNAL,  38  (11): (e23681).  [PMID:38814725] [10.1096/fj.202302155RRR]

3. He Chengjian, Song Xiaojing, Zhu Zigui, Xiao Yan, Chen Jiacheng, Yao Hongyi, Xie Rongjun.  (2024)  Ghrelin may protect against vascular endothelial injury in Acute traumatic coagulopathy by mediating the RhoA/ROCK/MLC2 pathway.  JOURNAL OF THROMBOSIS AND THROMBOLYSIS,      [PMID:39179950] [10.1007/s11239-024-03029-3]