SGC-SMARCA-BRDVIII - ≥99% , CAS No.1997319-84-2

CAS: 1997319-84-2 Cat. No.: S649566 Molecular Weight: 371.43

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5) , with K d s of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3) , with K d s of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts

In Vitro

SGC-SMARCA-BRDVIII (compound 22) (1 μM; 14 days) blocks adipocyte differentiation in 3T3-L1 murine fibroblasts. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Kd: 35 nM (SMARCA2), 36 nM (SMARCA4), 13 nM (PB1(5))

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2/4 and PB1(5) , with K d s of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3) , with K d s of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3O)=C2)OC(C)(C)C
• Molecular Weight: 371.43

Chemical and Physical Properties

• Solubility: DMSO : 25 mg/mL (67.31 mM; ultrasonic and warming and heat to 60°C)