≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides
In Vitro
SKF-34288 hydrochloride (0.01-1 mM, 48 h) inhibits C2C12 cell proliferation . SKF-34288 hydrochloride (0.25-1 mM, 0-5 day) induces myogenic differentiation of C2C12 cells . SKF-34288 hydrochloride (0.25 or 1 mM) reduces mRNA expression of Pck2 and genes associated with serine biosynthesis . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay Cell Line: C2C12 cell Concentration: 0, 0.01, 0.1, 0.25, 0.5, 1 mM Incubation Time: 48 h Result: Dose-dependently inhibited C2C12 cell proliferation.
In Vivo
SKF-34288 hydrochloride (37.5-150mg/kg, p.o.) reduces blood glucose in starved rats . SKF-34288 hydrochloride (25 mg/kg, s.c.) neutralizes Salbutamol- mediated hyperglycaemia in rabbits. SKF-34288 hydrochloride (30 and 300 mg/kg, i.p.) reduces Pyruvate-induced blood glucose level in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Starved rats Dosage: 37.5, 75 and 150mg/kg Administration: Oral administration (p.o.) Result: Showed dose-dependent magnitude and duration of the hypoglycaemic effect.
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase ( PEPCK ) inhibitor ( K i : 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride a
Storage
Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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