SPDP (Succinimidyl 3-[2-pyridyldithio] propionate) - ≥95% , CAS No.68181-17-9

CAS: 68181-17-9 Cat. No.: S164298 Molecular Weight: 312.36 EC Number: 269-034-3 PubChem CID: 100682

GRADE & PURITY ≥95%

Synonyms

(SPDP);N-Succinimidyl 3-[2-pyridyldithio]propionate | 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione | 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- | SPDP (2mg*5) | 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester | 3-(Py

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

SPDP crosslinker, N-Succinimidyl 3-(2-pyridyldithio) propionic acid, also called N-succinimidyl 3-(2-pyridyldithio)-propionate, or OPSS-NHS, is a short-length crosslinker for amine to sulfhydryl (thiol) conjugation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups. Nanocs LC-SPDP is a long-length crossliker for amine to sulfhydryl conjugation via its NHS-ester and pyridyldithiol reactive groups that form cleavable disulfide bonds with free thiol groups.
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for antibody conjugation and as a protein cross-linker.

Specifications

Synonyms

(SPDP);N-Succinimidyl 3-[2-pyridyldithio]propionate | 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2, 5-dione | 2, 5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- | SPDP (2mg*5) | 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester | 3-(Py

Specifications & Purity

≥95%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
• InChIKey: JWDFQMWEFLOOED-UHFFFAOYSA-N
• INCHI: 1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
• Isomeric SMILES: C1CC(=O)N(C1=O)OC(=O)CCSSC2=CC=CC=N2
• PubChem CID: 100682
• Molecular Weight: 312.36

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyridines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyridines and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridines and derivatives
• Alternative Parents: Pyrrolidine-2-ones Heteroaromatic compounds Dicarboximides Organic disulfides Lactams Carboxylic acid salts Sulfenyl compounds Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine - Pyrrolidone - 2-pyrrolidone - Dicarboximide - Pyrrolidine - Heteroaromatic compound - Carboxylic acid salt - Lactam - Organic disulfide - Azacycle - Carboxylic acid derivative - Sulfenyl compound - Monocarboxylic acid or derivatives - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Organic oxygen compound - Organopnictogen compound - Organic salt - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyridines and derivatives. These are compounds containing a pyridine ring, which is a six-member aromatic heterocycle which consists of one nitrogen atom and five carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: acetone: 50 mg/mL；DMF: soluble
• Sensitivity: heat sensitive ; light sensitive; Moisture sensitive
• Melt Point(°C): 84-86°C
• Molecular Weight: 312.400 g/mol
• XLogP3: 0.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 312.024 Da
• Monoisotopic Mass: 312.024 Da
• Topological Polar Surface Area: 127.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 376.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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