Succinyl phosphonate trisodium salt - ≥98% , CAS No.864167-45-3

CAS: 864167-45-3 Cat. No.: S648293 Molecular Weight: 248.01 PubChem CID: 138911342

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase ( KGDHC ) inhibitor, effective inhibits ( KGDHC ) in muscle, bacterial , brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase ( OGDH ) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ

Form:Solid

IC50& Target:α-ketoglutarate dehydrogenase,2-oxoglutarate dehydrogenase,ROS production

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase ( KGDHC ) inhibitor, effective inhibits ( KGDHC ) in muscle, bacterial , brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehy

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: C(CC(=O)P(=O)([O-])[O-])C(=O)[O-].[Na+].[Na+].[Na+]
• IUPAC Name: trisodium;4-oxo-4-phosphonatobutanoate
• InChIKey: QHBOYEUINLIJDF-UHFFFAOYSA-K
• INCHI: 1S/C4H7O6P.3Na/c5-3(6)1-2-4(7)11(8,9)10;;;/h1-2H2,(H,5,6)(H2,8,9,10);;;/q;3*+1/p-3
• PubChem CID: 138911342
• Molecular Weight: 248.01

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acids and conjugates
• Alternative Parents: Organic phosphonic acids and derivatives Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Fatty acid - Organophosphonic acid derivative - Carboxylic acid salt - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Organophosphorus compound - Organooxygen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as fatty acids and conjugates. These are aliphatic monocarboxylic acids with a saturated or unsaturated aliphatic tail (with at least 4 Carbon atoms).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: H2O : 150 mg/mL (604.81 mM; Need ultrasonic)