TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] - ≥97%(N) , CAS No.36951-72-1

CAS: 36951-72-1 Cat. No.: T162409 Molecular Weight: 1363.6 EC Number: 636-829-5

GRADE & PURITY ≥97%(N)

Synonyms

TMPyP | 5,10,15,20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) | α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] (TMPyP) is a positively charged, two-photon dye, that can bind to DNA in cell cultures and affect the cell viability. Long term encapsulation of TMPyP by nanoparticles is reported to prevent the dye from direct contact with cells, but the dye can still kill the cells via singlet-oxygen production on exposure to infrared light. Nanostructured catalyst of platinum nanoparticles supported on TMPyP functionalized graphene is prepared by hydrothermal polyol process. TMPyP is reported to show excellent 1O2 luminescence signals on incubation with the fungus, Candida albicans. On photoexcitation, TMPyP undergoes charge-transfer interaction with chemically reduced graphene oxide. It is also reported to be a promising photodynamic therapy photosensitizer.

TMPyP [=α,β,γ,δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate] (TMPyP), a cationic porphyrin, was used to study the noncovalent functionalization of graphene with cationic porphyrins using UV-vis and fluorescence methods. TMPyP may be used as an optical indicator ligand in the preparation of multifunctional membrane for visual warning and enhanced adsorptive removal of cadmium ions in aqueous solutions. TMPyP was also used to fabricate the (TMPyP)- single-walled carbon nanotubes (SWNT)/sodium copper chlorophyllin-SWNT layer-by-layer film from noncovalently adsorbed composites.

Specifications

Synonyms

TMPyP | 5, 10, 15, 20-Tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) | α, β, γ, δ-Tetrakis(1-methylpyridinium-4-yl)porphyrin p-Toluenesulfonate

Specifications & Purity

≥97%(N)

Biochemical and Physiological Mechanisms

Cationic porphyrin. Telomerase inhibitor (IC 50 = 6.5 µM). Binds and stabilizes DNA G quadruplexes resulting in telomerase inhibition. Displays antitumor effect.

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%(N)

Names and Identifiers

• Molecular Weight: 1363.6
• Reaxy-Rn: 5237096

Chemical and Physical Properties

• Solubility: water: soluble 50 mM(lit.)
• Sensitivity: Light & Moisture Sensitive

References

1. Decheng Lu, Xiaoqian Zhou, Lixing Lin, Xinying Zhang, Yingying Chen, Lingyan Feng.  (2024)  Porphyrin-functionalized glutathione-Ti3C2 MXene quantum dots for enhanced electrochemiluminescence and sensitive detection of copper ions.  JOURNAL OF ELECTROANALYTICAL CHEMISTRY,      [PMID:] [10.1016/j.jelechem.2024.118285]

2. Xiaohui Chen, Haixia Liu, Ningyu Ma, Chenyu Sun, Yican Li, Hengyi Chen, Qianqian Wu, Zhizeng Wang, Jichun Yang, Guoxiang Liu, Yang Luo.  (2025)  Precise Determination of CpG Methylation through Entropy-Driven Cascade Circuit.  ANALYTICAL CHEMISTRY,      [PMID:40478770] [10.1021/acs.analchem.5c01453]