Urantide, Antagonist of UT receptor, CAS No.669089-53-6, Antagonist of UT receptor

CAS: 669089-53-6 Cat. No.: U288432 Molecular Weight: 1075.26 PubChem CID: 11520939

GRADE & PURITY Moligand™

Specifications

Product Name

Urantide, Antagonist of UT receptor, CAS No.669089-53-6

Synonyms

[Pen5, DTrp7, Orn8]hU-II(4-11)

Grade

Moligand™

Specifications & Purity

Moligand™

Biochemical and Physiological Mechanisms

Selective and competitive urotensin-II (UT) receptor antagonist (pKB= 8.3). Blocks hU-II induced contractions in thoracic aortaex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves

Sequence

DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7)

Action Type

ANTAGONIST

Mechanism of action

Antagonist of UT receptor

CAS

669089-53-6

Molecule Type

Protein

Storage and Shipping

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Oligopeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Oligopeptides
• Alternative Parents: Cyclic peptides Aspartic acid and derivatives Valine and derivatives N-acyl-L-alpha-amino acids Macrolactams Alpha amino acid amides 3-alkylindoles 1-hydroxy-2-unsubstituted benzenoids Substituted pyrroles N-acyl amines Benzene and substituted derivatives Dicarboxylic acids and derivatives Heteroaromatic compounds Lactams Amino acids Organic disulfides Secondary carboxylic acid amides Carboxylic acids Azacyclic compounds Hydrocarbon derivatives Carbonyl compounds Monoalkylamines Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Alpha-oligopeptide - Cyclic alpha peptide - Aspartic acid or derivatives - N-acyl-alpha amino acid or derivatives - Valine or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha-amino acid - Macrolactam - Alpha-amino acid amide - Alpha-amino acid or derivatives - 3-alkylindole - Indole - Indole or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Benzenoid - Substituted pyrrole - Fatty acyl - N-acyl-amine - Fatty amide - Dicarboxylic acid or derivatives - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Organic disulfide - Amino acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Lactam - Amino acid - Carboxylic acid - Organoheterocyclic compound - Azacycle - Organonitrogen compound - Hydrocarbon derivative - Organic nitrogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic oxide - Primary amine - Amine - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

UTS2R Tchem Urotensin-2 receptor (0 Activities)

Discover Target: UTS2R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UTS2R Tchem Urotensin II receptor (1388 Activities)

Discover Target: UTS2R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Genetic information

• Alternate Names: [Pen5,DTrp7,Orn8]hU-II(4-11)
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