Vincristine-d3-ester sulfate - ≥99% , CAS No.1217854-24-4

CAS: 1217854-24-4 Cat. No.: V651826 Molecular Weight: 926.05 EC Number: 218-190-0 PubChem CID: 21864436

GRADE & PURITY ≥99%

Synonyms

Vincristine sulfate | MLS002702994 | Oncovin;Vincasar PFS;Vincrex;Leurocristine sulfate ;Leurocristine sulfate salt;22-Oxovincaleukoblastine sulfate | BCP02863 | SMR001566803 | PD046103 | 1217854-24-4

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Vincristine-d 3 -ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Synonyms

Vincristine sulfate | MLS002702994 | Oncovin;Vincasar PFS;Vincrex;Leurocristine sulfate ;Leurocristine sulfate salt;22-Oxovincaleukoblastine sulfate | BCP02863 | SMR001566803 | PD046103 | 1217854-24-4

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Vincristine-d 3 -ester (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
• IUPAC Name: methyl 11-acetyloxy-12-ethyl-4-(17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl)-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
• InChIKey: AQTQHPDCURKLKT-UHFFFAOYSA-N
• INCHI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)
• Isomeric SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
• Alternate CAS: 2068-78-2
• PubChem CID: 21864436
• UN Number: 1544
• MeSH Entry Terms: cellcristin;Citomid;Farmistin;Leurocristine;Oncovin;Oncovine;Onkocristin;PFS, Vincasar;Sulfate, Vincristine;Vincasar;Vincasar PFS;Vincristin Bristol;Vincristin medac;Vincristine;Vincristine Sulfate;Vincrisul;Vintec
• Molecular Weight: 926.05

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Class Vinca alkaloids

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Class: Vinca alkaloids
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Vinca alkaloids
• Alternative Parents: Carbazoles 3-alkylindoles Tricarboxylic acids and derivatives Anisoles Aralkylamines Alkyl aryl ethers N-alkylpyrrolidines Piperidines Organic sulfuric acids Methyl esters Pyrroles Heteroaromatic compounds Tertiary alcohols Tertiary carboxylic acid amides Trialkylamines Cyclic alcohols and derivatives Amino acids and derivatives 1,2-aminoalcohols Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Vinca alkaloid skeleton - Carbazole - 3-alkylindole - Indole - Indole or derivatives - Tricarboxylic acid or derivatives - Anisole - Alkyl aryl ether - Sulfuric acid - Aralkylamine - Piperidine - Benzenoid - N-alkylpyrrolidine - Cyclic alcohol - Heteroaromatic compound - Organic sulfuric acid or derivatives - Pyrrole - Pyrrolidine - Tertiary alcohol - Tertiary carboxylic acid amide - Methyl ester - Tertiary aliphatic amine - Tertiary amine - Amino acid or derivatives - Carboxamide group - 1,2-aminoalcohol - Carboxylic acid ester - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Ether - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Carbonyl group - Amine - Alcohol - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as vinca alkaloids. These are alkaloids with a dimeric chemical structure composed of an indole nucleus (catharanthine), and a dihydroindole nucleus (vindoline), joined together.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HEK293 (82097 Activities)

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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GMNN Tbio Geminin (128009 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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NR0B1 Tbio Nuclear receptor subfamily 0 group B member 1 (493 Activities)

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Associated Targets(non-human)

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

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clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

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Mechanisms of Action