ZL0420 - 10mM in DMSO , CAS No.2230496-80-5

CAS: 2230496-80-5 Cat. No.: Z655434 Molecular Weight: 296.32 PubChem CID: 137285011

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with IC 50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.

In Vitro

ZL0420 is well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H 2 O molecule. ZL0420 exhibits submicromolar potency of inhibiting the TLR3-dependent innate immune gene program, including ISG54, ISG56, IL-8, and Groβ genes in cultured human small airway epithelial cells (hSAECs) with IC 50 s of 0.49-0.86 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZL0420 demonstrates potent efficacy reducing airway inflammation in a mouse model with low toxicity. ZL0420 displays high efficacy and almost completely blocks the profound accumulation of neutrophils around the small and medium sized airways induced by poly(I:C) administration . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 27 nM (BRD4 BD1), 32 nM (BRD4 BD2)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

ZL0420 is a potent and selective bromodomain-containing protein 4 ( BRD4 ) inhibitor with IC 50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=CC(=C(C=C1O)N)N=NC2=CC3=C(C=C2)NC(=O)CC3
• PubChem CID: 137285011
• Molecular Weight: 296.32