1h-pyrazolo[3,4-b]pyridin-3-amine - ≥97% , CAS No.6752-16-5

CAS: 6752-16-5 Cat. No.: H133980 Molecular Weight: 134.14 EC Number: 663-100-9

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1h-pyrazolo[3,4-b]pyridin-3-amine - ≥97% CAS No(6752-16-5) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥97%

Synonyms

1h-pyrazol[3,4]pyridin-3-amine | A835790 | SY007922 | 9H-purin-6-amine,9-[5-O-[hydroxy[[hydroxy[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxopropyl)thio]ethyl]amino]propyl]amino]butyl]oxy]phosphinyl]oxy]phosphinyl]-3-O-phosphono-beta-D-ribof

Storage

Argon charged,Room temperature

Shipped In

Normal

Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Argon charged,Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

1h-pyrazol[3, 4]pyridin-3-amine | A835790 | SY007922 | 9H-purin-6-amine, 9-[5-O-[hydroxy[[hydroxy[[(3R)-3-hydroxy-2, 2-dimethyl-4-oxo-4-[[3-oxo-3-[[2-[(1-oxopropyl)thio]ethyl]amino]propyl]amino]butyl]oxy]phosphinyl]oxy]phosphinyl]-3-O-phosphono-beta-D-ribof

Specifications & Purity

≥97%

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥97%

Names and Identifiers

Pubchem Sid	488188923
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188923
Canonical Smiles	C1=CC2=C(NN=C2N=C1)N
IUPAC Name	2H-pyrazolo[3,4-b]pyridin-3-amine
InChIKey	LUAQTQAFUORQHV-UHFFFAOYSA-N
INCHI	1S/C6H6N4/c7-5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H3,7,8,9,10)
Isomeric SMILES	C1=CC2=C(NN=C2N=C1)N
WGK Germany	1
Molecular Weight	134.14
Reaxy-Rn	19040328
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19040328&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrazolopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrazolopyridines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Pyrazolopyridines
Alternative Parents	Pyridines and derivatives Pyrazoles Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Pyrazolopyridine - Pyridine - Heteroaromatic compound - Pyrazole - Azole - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Organonitrogen compound - Amine - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyrazolopyridines. These are compounds containing a pyrazolopyridine skeleton, which consists of a pyrazole fused to a pyridine. Pyrazole is 5-membered ring consisting of three carbon atoms and two adjacent nitrogen centers. Pyridine is a 6-membered ring with four carbon and one nitrogen atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

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MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

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GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

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AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)

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IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)

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AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

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ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)

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PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

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JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

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SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

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ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 Activities)

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MAPKAPK2 Tchem MAP kinase-activated protein kinase 2 (4814 Activities)

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PIK3CD Tclin PI3-kinase p110-delta subunit (6699 Activities)

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PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)

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PIK3CG Tclin PI3-kinase p110-gamma subunit (5411 Activities)

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MAPK8 Tchem c-Jun N-terminal kinase 1 (5038 Activities)

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AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

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PDK1 Tchem Pyruvate dehydrogenase kinase isoform 1 (2021 Activities)

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ERBB4 Tclin Receptor protein-tyrosine kinase erbB-4 (2748 Activities)

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SGK1 Tchem Serine/threonine-protein kinase Sgk1 (2343 Activities)

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AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

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RIPK2 Tchem Serine/threonine-protein kinase RIPK2 (1546 Activities)

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MAP3K5 Tchem Mitogen-activated protein kinase kinase kinase 5 (1965 Activities)

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MKNK2 Tchem MAP kinase signal-integrating kinase 2 (3518 Activities)

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FES Tclin Tyrosine-protein kinase FES (2339 Activities)

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PAK2 Tchem Serine/threonine-protein kinase PAK 2 (1925 Activities)

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BRAF Tclin Serine/threonine-protein kinase B-raf (11587 Activities)

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Associated Targets(non-human)

PIK3CA PI3-kinase p110-alpha subunit (51 Activities)

Discover Target: PIK3CA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
G2320095	Certificate of Analysis	May 09, 2026	H133980
G1922300	Certificate of Analysis	Feb 08, 2025	H133980

Chemical and Physical Properties

Melt Point(°C)	187-192°C
Molecular Weight	134.140 g/mol
XLogP3	0.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	134.059 Da
Monoisotopic Mass	134.059 Da
Topological Polar Surface Area	67.600 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	127.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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