5-Methoxyquinolin-8-amine - ≥97% , CAS No.30465-68-0

CAS: 30465-68-0 Cat. No.: M192632 Molecular Weight: 174.2 EC Number: 842-342-0

GRADE & PURITY ≥97%

Synonyms

A820582 | Oprea1_798026 | 8-Amino-5-methoxyquinoline, 95% | F19180 | Z364003430 | 5-methoxyquinolin-8-amine | 5-methoxy-8-quinolinamine | 5-Methoxy-quinolin-8-ylamine | STK309777 | A820385 | LCZC1977 | 5-methoxy-8-aminoquinoline | AKOS000129566 | EN300-14

Storage

Argon charged,Room temperature

Shipped In

Normal

Overview

8-Amino-5-methoxyquinoline is a substituted quinoline derivative that can be prepared using 5-chloro-2-nitroaniline as a starting material. It can act as an easily removable directing group and also mediate C-H activation. These properties have been useful for synthesizing isomeric dibenzoxazepinones and complex pyrrolidinones from compounds containing 8-amino-5-methoxyquinoline moiety.

Application：

The Chen auxiliary was reported to be an effective directing group in the synthesis of pyrrolidones from assisting in the activation of C(sp3)-H bonds and can be readily installed through amide bond formation and removed through mild conditions using CAN at room temperature.

Specifications

Synonyms

A820582 | Oprea1_798026 | 8-Amino-5-methoxyquinoline, 95% | F19180 | Z364003430 | 5-methoxyquinolin-8-amine | 5-methoxy-8-quinolinamine | 5-Methoxy-quinolin-8-ylamine | STK309777 | A820385 | LCZC1977 | 5-methoxy-8-aminoquinoline | AKOS000129566 | EN300-14

Specifications & Purity

≥97%

Storage

Argon charged, Room temperature

Shipped In

Normal

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488191466
• Canonical Smiles: COC1=C2C=CC=NC2=C(C=C1)N
• IUPAC Name: 5-methoxyquinolin-8-amine
• InChIKey: MFLLTRMMFHENCM-UHFFFAOYSA-N
• INCHI: 1S/C10H10N2O/c1-13-9-5-4-8(11)10-7(9)3-2-6-12-10/h2-6H,11H2,1H3
• Isomeric SMILES: COC1=C2C=CC=NC2=C(C=C1)N
• Molecular Weight: 174.2
• Reaxy-Rn: 143401
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=143401&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Aminoquinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Aminoquinolines and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminoquinolines and derivatives
• Alternative Parents: Methoxyanilines Anisoles Alkyl aryl ethers Pyridines and derivatives Heteroaromatic compounds Azacyclic compounds Primary amines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Aminoquinoline - Methoxyaniline - Anisole - Alkyl aryl ether - Pyridine - Benzenoid - Heteroaromatic compound - Ether - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as aminoquinolines and derivatives. These are organic compounds containing an amino group attached to a quinoline ring system.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Air sensitive
• Molecular Weight: 174.200 g/mol
• XLogP3: 1.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 174.079 Da
• Monoisotopic Mass: 174.079 Da
• Topological Polar Surface Area: 48.100 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 174.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1