6-Demethoxytangeretin - ≥99% , CAS No.6601-66-7

CAS: 6601-66-7 Cat. No.: D651132 Molecular Weight: 342.34 PubChem CID: 629964

GRADE & PURITY ≥99%

Synonyms

6-Demethoxytangeretin | AC-34592 | 2U2U884D0P | 6-Demethoxytangeritin | Tetra-O-methylisoscutellarein | 5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one | DTXSID20348077 | HY-N4126 | 4',5,7,8-Tetramethoxyflavone | AKOS025287977 | 5,7,8-Trimethoxy-2-(4-me

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata. 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase ( ALK ) and mitogen-activated protein kinase ( MAPK ) pathways. 6-Demethoxytangeretin facilitates the CRE-mediated transcription associated with learning and memory in cultured hippocampal neurons .

Form:Solid

Specifications

Synonyms

6-Demethoxytangeretin | AC-34592 | 2U2U884D0P | 6-Demethoxytangeritin | Tetra-O-methylisoscutellarein | 5, 7, 8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one | DTXSID20348077 | HY-N4126 | 4', 5, 7, 8-Tetramethoxyflavone | AKOS025287977 | 5, 7, 8-Trimethoxy-2-(4-me

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus reticulata . 6-Demethoxytangeretin exerts anti-inflammatory activity and anti-allergic activity, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplasti

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Canonical Smiles: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)OC
• IUPAC Name: 5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
• InChIKey: DDGJUTBQQURRGE-UHFFFAOYSA-N
• INCHI: 1S/C19H18O6/c1-21-12-7-5-11(6-8-12)14-9-13(20)17-15(22-2)10-16(23-3)18(24-4)19(17)25-14/h5-10H,1-4H3
• Isomeric SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3OC)OC)OC
• Alternate CAS: 6601-66-7
• PubChem CID: 629964
• MeSH Entry Terms: 6-demethoxytangeretin
• Molecular Weight: 342.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Class Flavonoids
      • Subclass O-methylated flavonoids

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Class: Flavonoids
• Subclass: O-methylated flavonoids
• Intermediate Tree Nodes: Not available
• Direct Parent: 8-O-methylated flavonoids
• Alternative Parents: 7-O-methylated flavonoids 5-O-methylated flavonoids 4'-O-methylated flavonoids Flavones Chromones Phenoxy compounds Methoxybenzenes Anisoles Pyranones and derivatives Alkyl aryl ethers Vinylogous esters Heteroaromatic compounds Oxacyclic compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 4p-methoxyflavonoid-skeleton - 5-methoxyflavonoid-skeleton - 7-methoxyflavonoid-skeleton - 8-methoxyflavonoid-skeleton - Flavone - Chromone - Benzopyran - 1-benzopyran - Phenoxy compound - Methoxybenzene - Anisole - Phenol ether - Pyranone - Alkyl aryl ether - Monocyclic benzene moiety - Pyran - Benzenoid - Heteroaromatic compound - Vinylogous ester - Oxacycle - Organoheterocyclic compound - Ether - Organic oxide - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 8-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C8 atom of the flavonoid backbone.
• External Descriptors: Flavones and Flavonols

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 12.5 mg/mL (36.51 mM; ultrasonic and warming and heat to 60°C)
• Molecular Weight: 342.300 g/mol
• XLogP3: 3.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 342.11 Da
• Monoisotopic Mass: 342.11 Da
• Topological Polar Surface Area: 63.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 496.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1