A-83-01 - 10mM in DMSO , CAS No.909910-43-6

CAS: 909910-43-6 Cat. No.: A408570 Molecular Weight: 421.52 EC Number: 635-614-3

GRADE & PURITY 10mM in DMSO

Synonyms

1H-​Pyrazole-​1-​carbothioamide, 3-​(6-​methyl-​2-​pyridinyl)​-​N-​phenyl-​4-​(4-​quinolinyl)​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

A-83-01 is a potent inhibitor ofTGF-β type I receptor (ALK5-TD)with IC50 of 12 nM. A-83-01 also inhibits the transcription induced byactivin/nodal type I receptor (ALK4-TD)andnodal type I receptor (ALK7-TD)with IC50 of 45 nM and 7.5 nM, respectively.Solut
In vitro

A-83-01 inhibits the transcriptional activity induced by TGF-β type I receptor ALK-5 and that by activin type IB receptor ALK-4 and nodal type I receptor ALK-7, the kinase domains of which are structurally highly related to those of ALK-5. A-83-01 is potent in the inhibition of ALK5 and also prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-β.

In vivo

A83-01 treatment significantly increases the number of Nkx2.5+ cardiomyoblasts at baseline and after myocardial injury, resulting in an increase in newly formed cardiomyocytes. A83-01 treatment significantly improves ventricular elastance and stroke work, leading to improved contractility after injury.
Cell Data

cell lines：

Concentrations：1 μM

Incubation Time：1 h

Powder Purity:

Specifications

Synonyms

1H-​Pyrazole-​1-​carbothioamide, 3-​(6-​methyl-​2-​pyridinyl)​-​N-​phenyl-​4-​(4-​quinolinyl)​-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
• Molecular Weight: 421.52
• Reaxy-Rn: 15627575
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15627575&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 47 mg/mL (197.28 mM)