Bcl-xL antagonist 2 - ≥98% , CAS No.1235032-75-3

CAS: 1235032-75-3 Cat. No.: B650887 Molecular Weight: 436.51

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-X L with an IC 50 and K i of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL)

In Vivo

Assessment of Pharmacokinetics (PK) profile of Bcl-xL antagonist 2 (compound 14) in rat . iv (1 mg/kg) po (5 mg/kg) CL p (mL/min/kg) V ss (L/kg) t 1/2 (h) F % 0.47 0.16 6.0 16 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:0.091 μM (BCL-X L )

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-X L with an IC 50 and K i of 0.091 μM and 65 nM, respectively. Bcl-xL antagonist 2 promotes the apoptosis of cancer cells. Bcl-xL antagonist 2 has the potential for the resear

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%

Names and Identifiers

• Molecular Weight: 436.51

Chemical and Physical Properties

• Solubility: DMSO : 62.5 mg/mL (143.18 mM; Need ultrasonic)