Chrysamine G , CAS No.6472-91-9

CAS: 6472-91-9 Cat. No.: C276464 Molecular Weight: 526.41 PubChem CID: 135475357

Synonyms

Benzoic acid, 3,3'-((1,1'-biphenyl)-4,4'-diylbis(azo))bis(6-hydroxy-, disodium salt | Chrysamine | DTXSID801023495 | 3,3'-((1,1'-Biphenyl)-4,4'-diylbis(azo))bis(6-hydroxybenzoic acid), disodium salt | direct yellow 1 | disodium;2-carboxy-4-[[4-[4-[(3-carb

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Store at -20°C. Store In the Dark. Store under desiccating conditions.

Specifications

Synonyms

Benzoic acid, 3, 3'-((1, 1'-biphenyl)-4, 4'-diylbis(azo))bis(6-hydroxy-, disodium salt | Chrysamine | DTXSID801023495 | 3, 3'-((1, 1'-Biphenyl)-4, 4'-diylbis(azo))bis(6-hydroxybenzoic acid), disodium salt | direct yellow 1 | disodium;2-carboxy-4-[[4-[4-[(3-carb

Biochemical and Physiological Mechanisms

Lipophilic, carboxylic acid analog of Congo red , shown to bind to the β-amyloid protein in vitro .\xa0Binding to the β-amyloid protein\xa0inhibits its neurodegenerative activity.\xa0Chrysamine G inhibits β-amyloid due to its antioxidant acitv

Storage

Protected from light, Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

• Canonical Smiles: C1=CC(=CC=C1C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)[O-])C(=O)O)N=NC4=CC(=C(C=C4)[O-])C(=O)O.[Na+].[Na+]
• IUPAC Name: disodium;2-carboxy-4-[[4-[4-[(3-carboxy-4-oxidophenyl)diazenyl]phenyl]phenyl]diazenyl]phenolate
• InChIKey: AZOPGDOIOXKJRA-UHFFFAOYSA-L
• INCHI: 1S/C26H18N4O6.2Na/c31-23-11-9-19(13-21(23)25(33)34)29-27-17-5-1-15(2-6-17)16-3-7-18(8-4-16)28-30-20-10-12-24(32)22(14-20)26(35)36;;/h1-14,31-32H,(H,33,34)(H,35,36);;/q;2*+1/p-2
• Isomeric SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)[O-])C(=O)O)N=NC4=CC(=C(C=C4)[O-])C(=O)O.[Na+].[Na+]
• WGK Germany: 3
• PubChem CID: 135475357
• Molecular Weight: 526.41

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzidines
• Alternative Parents: Azobenzenes Salicylic acids Benzoic acids Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Carboxylic acid salts Azo compounds Propargyl-type 1,3-dipolar organic compounds Carboxylic acids Organooxygen compounds Organic zwitterions Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Azobenzene - Benzidine - Hydroxybenzoic acid - Salicylic acid or derivatives - Salicylic acid - Benzoic acid or derivatives - Benzoic acid - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Vinylogous acid - Carboxylic acid salt - Azo compound - Organic 1,3-dipolar compound - Organic alkali metal salt - Carboxylic acid derivative - Propargyl-type 1,3-dipolar organic compound - Carboxylic acid - Organonitrogen compound - Organic zwitterion - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic sodium salt - Organic nitrogen compound - Organic salt - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzidines. These are organic compounds containing the benzidine skeleton, made up of a biphenyl ring system substituted at the 4- and 4'-positions with a unsubstituted amine group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in DMSO
• Molecular Weight: 526.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 526.087 Da
• Monoisotopic Mass: 526.087 Da
• Topological Polar Surface Area: 170.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 740.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3