GRADE & PURITY 10mM in DMSO

Synonyms

2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2Z)-2-butenedioate (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Cinepazide maleate Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
In vitro

In vivo

Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia.
Cell Data

cell lines：HL-60, NB4, MOLM13, PALL-2, MV4-11, EOL-1, and K562 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3, 4, 5-trimethoxyphenyl)-, (2Z)-2-butenedioate (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=C\C(=O)O)\C(=O)O
• PubChem CID: 5282458
• Molecular Weight: 533.57

Chemical and Physical Properties

• Melt Point(°C): 173 °C(dec.)