≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
CNQX disodium salt hydrate has been used as:
as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)
Biochemical mechanism:
CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.
Water soluble, potent, competitive AMPA / kainate receptor antagonist. Also antagonist at NMDA receptor glycine site. Also available in simple stock solutions add 1 ml of water to get an exact, ready-to-use concentration.
Storage
Protected from light, Store at -20°C, Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as quinoxalines. These are compounds containing a quinoxaline moiety, a bicyclic heterocycle made up of a benzene ring fused to a pyrazine ring.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Yue-Heng Yan, Hong-Kun Wang, Zi-Hao Wang, Rui-Ze Wang, Ruo-Xuan Li, Li-Li Huang, Yan-Yan Wang. (2025) Effects of anxiety induced by conditioned fear on the expression of NMDA receptors and synaptic plasticity in the rat BLA. BEHAVIOURAL BRAIN RESEARCH, [PMID:40132761][10.1016/j.bbr.2025.115547]
2.Bo Shen, Zhengqiu Chen, Junyu Chen, Ning Wang, Huaming Mao, Jungang Yin, Yu Ren, Wei Dai, Shuanglong Zhao, Hongwei Yang. (2025) Pervasive Construction of Cu@Ag Core–Shell Structures Driven by Glutamate Coordination. CRYSTAL GROWTH & DESIGN, [PMID:][10.1021/acs.cgd.5c01031]
3.Xianyu Guo, Wentao Tan, Ling Wang, Fengrui Yang, Yuhang Ma, Yi Shen, Caihong Luo, Qian Luo, Xiao Xie, Hui Li. (2026) DES-PMMA-assisted preparation of D-Serine chiral imprinted polymers and its molecular recognition behavior. POLYMER, [PMID:][10.1016/j.polymer.2026.129591]
4.Simin Zhang, Xiangfeng Chen, Yaping Shi, Xiangyu Zhu, Zongwei Cai. (2026) Soft-Chain-Induced Ultrahigh-Resolution Chiral Separation of Amino Acids via Bimetallic Immobilization in MALDI-TIMS-MS. ANALYTICAL CHEMISTRY, [PMID:41701523][10.1021/acs.analchem.5c07869]
5.Hong-Ru Zhao, Wen-Tao Shen, Bingmei Su, Lian Xu, Juan Lin. (2026) Multi-strategy engineering of transaminase enables a one-pot synergistic biocatalytic cascade to a key florfenicol chiral intermediate. GREEN CHEMISTRY, [PMID:][10.1039/D5GC06908D]
Solution Calculators
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