Cucurbitacin D - ≥99% , CAS No.3877-86-9

Name: Cucurbitacin D - ≥99% , CAS No.3877-86-9
Brand: Aladdin Scientific
SKU: C651710
Availability: InStock

CAS: 3877-86-9 Cat. No.: C651710 Formula: C₃₀H₄₄O₇ Peso molecolare: 516.67 Numero EC: 686-158-7 PubChem CID: 5281318

COA

Vai alla fine della galleria di immagini

Cucurbitacin D - ≥99% CAS No(3877-86-9) by Aladdin Scientific

Vai all'inizio della galleria di immagini

Disponibile su ordine

QUALITÀ & PUREZZA ≥99%

Synonyms

(23E)-2beta,16alpha,20,25-tetrahydroxy-10alpha-cucurbita-5,23-diene-3,11,22-trione | NSC 308606 | 19-Nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione, 9-methyl-2-beta,16-alpha,20,25-tetrahydroxy- | 19-Norlanosta-5,23-diene-3,11,22-trione,2,16,20,25-t

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Scheda delle specifiche

Panoramica Specifiche Nomi e identificatori Dati avanzati Taxonomic Classification Struttura 3D Obiettivi associati (umani) Obiettivi associati (non umani) Meccanismi d'azione Certificati (CoA, COO, BSE/TSE e tabella di analisi) Proprietà chimiche e fisiche Calcolatori di soluzioni Recensioni

Panoramica

Cucurbitacin D is an active component in Trichosanthes kirilowii , disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf , Cdk6 , pAkt) maturation without induction of the heat shock response. Anti-cancer activity

Form:Solid

IC50& Target:HSP90

Specifiche

Sinonimi

Specifiche e purezza

≥99%

Meccanismi biochimici e fisiologici

Condizioni di conservazione di stoccaggio

Protected from light,Store at -80°C

Spedito in

Dry ice packs + Cold packs

Questo prodotto richiede spedizione a catena fredda. I servizi di terra e altri servizi economici non sono disponibili.

Tipo di azione

ACTIVATOR

Purezza

≥99%

Nomi e identificatori

Sorrisi canonici

CC1(C2=CCC3C4(CC(C(C4(CC(=O)C3(C2CC(C1=O)O)C)C)C(C)(C(=O)C=CC(C)(C)O)O)O)C)C

IUPAC Name

(2S,8S,9R,10R,13R,14S,16R,17R)-17-[(E,2R)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,11-dione

InChIKey

SRPHMISUTWFFKJ-QJNWWGCFSA-N

INCHI

1S/C30H44O7/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6/h9,11-12,17-20,23,31-32,36-37H,10,13-15H2,1-8H3/b12-11+/t17-,18+,19-,20+,23+,27+,28-,29+,30+/m1/s1

Isomeri SMILES

C[C@@]12C[C@H]([C@@H]([C@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)[C@](C)(C(=O)/C=C/C(C)(C)O)O)O

CAS alternativo

3877-86-9

PubChem CID

5281318

Numero NSC

308606

Termini MeSH

23,24-dihydro-cucurbitacin D;cucurbitacin D;elatericin A

Peso molecolare

516.67

Dati avanzati

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Classe Steroids and steroid derivatives
    - Subclass Cucurbitacins

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Classe	Steroids and steroid derivatives
Subclass	Cucurbitacins
Intermediate Tree Nodes	Not available
Direct Parent	Cucurbitacins
Alternative Parents	Triterpenoids 11-oxosteroids 14-alpha-methylsteroids 16-alpha-hydroxysteroids 3-oxo delta-5-steroids Delta-5-steroids Acyloins Tertiary alcohols Enones Acryloyl compounds Alpha-hydroxy ketones Secondary alcohols Cyclic ketones Cyclic alcohols and derivatives Organic oxides Hydrocarbon derivatives
Molecular Framework	Aliphatic homopolycyclic compounds
Substituents	Cucurbitacin skeleton - Triterpenoid - 25-hydroxysteroid - 22-oxosteroid - 21-oxosteroid - 20-hydroxysteroid - 14-alpha-methylsteroid - 2-hydroxysteroid - Hydroxysteroid - 3-oxo-delta-5-steroid - 11-oxosteroid - Oxosteroid - 3-oxosteroid - 16-alpha-hydroxysteroid - 16-hydroxysteroid - Delta-5-steroid - Acyloin - Alpha,beta-unsaturated ketone - Alpha-hydroxy ketone - Tertiary alcohol - Cyclic alcohol - Enone - Acryloyl-group - Cyclic ketone - Secondary alcohol - Ketone - Organic oxide - Alcohol - Organic oxygen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Aliphatic homopolycyclic compound
Descrizione	This compound belongs to the class of organic compounds known as cucurbitacins. These are polycyclic compounds containing the tetracyclic cucurbitane nucleus skeleton, 19-(10->9b)-abeo-10alanost-5-ene (also known as 9b-methyl-19-nor lanosta-5-ene), with a variety of oxygenation functionalities at different positions.
External Descriptors	Cholesterol and derivatives
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Struttura 3D

Obiettivi associati (umani)

ITGAL Tclin Leukocyte adhesion glycoprotein LFA-1 alpha (170 Activities)

Discover Target: ITGAL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Solubilità	DMSO : 110 mg/mL (212.90 mM; Need ultrasonic)
Peso molecolare	516.700 g/mol
XLogP3	2.100
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	516.309 Da
Monoisotopic Mass	516.309 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	1100.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

Cucurbitacin D - ≥99% , CAS No.3877-86-9

Panoramica

Specifiche

Dati avanzati

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Recensioni dei clienti

View related series