Diethoxy(3-glycidyloxypropyl)methylsilane - ≥98% , CAS No.2897-60-1

CAS: 2897-60-1 Cat. No.: D303333 Molecular Weight: 248.39 EC Number: 220-780-8
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
(3-(2,3-Epoxypropoxy)propyl)diethoxymethylsilane | (3-Glycidoxypropyl)methyldiethoxysilane | diethoxy-3-glycidoxypropylmethylsilane | Silane, (3-(2,3-epoxypropoxy)propyl)diethoxymethyl- | (3-Glycidyloxypropyl)methyldiethoxysilane | [3-(2,3-Epoxypropoxy)pr
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25ml
D303333-25ml
3
$9.90
100ml
D303333-100ml
3
$27.90
500ml
D303333-500ml
1
$62.90
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Diethoxy(3-glycidyloxypropyl)methylsilane (GPMS) is an epoxysilane which can be used as a silane coupling agent for the surface treatment of a variety of materials. These silanes can also be used as adhesion promoters by modifying the surface properties of the substrates and elastomeric materials.
Application
Coverslips coated with diethoxy(3-glycidyloxypropyl)methyl silane were used as sample holders for electrostatically holding particles for optical microscopy. It may be used to introduce epoxy groups to Fe3O4SiO2 nanoparticles.  Self assembled monolayer (SAMs) of diethoxy(3- glycidyloxypropyl)methylsilane could be formed on the oxide layer of silicon wafer to render them siloxane functionalities.
GPMS can be used in the surface modification of a variety of particles such as cellulose nanocrystals, silica nanomaterials and other silicon based substrates. It functionalizes these surfaces by attaching the epoxy-silane groups with the surface molecules.

Specifications

Synonyms
(3-(2, 3-Epoxypropoxy)propyl)diethoxymethylsilane | (3-Glycidoxypropyl)methyldiethoxysilane | diethoxy-3-glycidoxypropylmethylsilane | Silane, (3-(2, 3-epoxypropoxy)propyl)diethoxymethyl- | (3-Glycidyloxypropyl)methyldiethoxysilane | [3-(2, 3-Epoxypropoxy)pr
Specifications & Purity
≥98%
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid504753847
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504753847
Canonical SmilesCCO[Si](C)(CCCOCC1CO1)OCC
IUPAC Namediethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane
InChIKeyOTARVPUIYXHRRB-UHFFFAOYSA-N
INCHI1S/C11H24O4Si/c1-4-14-16(3,15-5-2)8-6-7-12-9-11-10-13-11/h11H,4-10H2,1-3H3
Isomeric SMILES CCO[Si](C)(CCCOCC1CO1)OCC
Molecular Weight 248.39
Reaxy-Rn 121965
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=121965&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganometallic compounds
ClassOrganometalloid compounds
SubclassOrganosilicon compounds
Intermediate Tree Nodes Not available
Direct ParentAlkoxysilanes
Alternative Parents Silyl ethers  Oxacyclic compounds  Organoheterosilanes  Organic metalloid salts  Epoxides  Dialkyl ethers  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Alkoxysilane - Silyl ether - Organoheterosilane - Oxacycle - Organic metalloid salt - Organoheterocyclic compound - Ether - Oxirane - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organic salt - Organooxygen compound - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as alkoxysilanes. These are organosilicon compounds with the general formula RO[Si](OR')(R'')(R''') (R,R' = organyl; R'',R''' = any atom).
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
B2324228Certificate of AnalysisDec 10, 2025 D303333
B2324235Certificate of AnalysisDec 10, 2025 D303333
K2504293Certificate of AnalysisOct 24, 2025 D303333
K2504448Certificate of AnalysisOct 24, 2025 D303333
H2508351Certificate of AnalysisJul 22, 2025 D303333
H2508352Certificate of AnalysisJul 22, 2025 D303333
H2508452Certificate of AnalysisJul 22, 2025 D303333
L2406418Certificate of AnalysisNov 27, 2024 D303333
L2406419Certificate of AnalysisNov 27, 2024 D303333
L2406420Certificate of AnalysisNov 27, 2024 D303333
J2528734Certificate of AnalysisMar 30, 2024 D303333
A2425014Certificate of AnalysisFeb 14, 2023 D303333
B2324240Certificate of AnalysisFeb 14, 2023 D303333

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Chemical and Physical Properties
SensitivityMoisture Sensitive
Refractive Index1.431
Flash Point(°C)122 °C
Boil Point(°C)122-126°C 5mm Hg (Lit.)
Molecular Weight248.390 g/mol
XLogP3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Exact Mass248.144 Da
Monoisotopic Mass248.144 Da
Topological Polar Surface Area40.200 Ų
Heavy Atom Count16
Formal Charge0
Complexity183.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Tongtong Zhang, Luoxiang Yang, Fei Yan, Kai Wang.  (2023)  Vertically-Ordered Mesoporous Silica Film Based Electrochemical Aptasensor for Highly Sensitive Detection of Alpha-Fetoprotein in Human Serum.  Biosensors-Basel,  13  (6): (628).  [PMID:37366993] [10.3390/bios13060628]
2. Jie Huang, Tongtong Zhang, Yanyan Zheng, Jiyang Liu.  (2023)  Dual-Mode Sensing Platform for Cancer Antigen 15-3 Determination Based on a Silica Nanochannel Array Using Electrochemiluminescence and Electrochemistry.  Biosensors-Basel,  13  (3): (317).  [PMID:36979529] [10.3390/bios13030317]
3. Shijie Dai, Wei Li, Ruimin Xu, Xin Wang, Qianjin Li, Menghua Dou, Jianlin Li.  (2022)  Label-Free Fluorescence Quantitative Detection Platform on Plasmonic Silica Photonic Crystal Microsphere Array.  ANALYTICAL CHEMISTRY,      [PMID:36519631] [10.1021/acs.analchem.2c04000]
4. Heyi Mao, Yidan Zhang, Lei Wang, Anduo Zhou, Shanfeng Zhang, Jing Cao, Huang Xia.  (2022)  Cyclopeptide-β-cyclodextrin/γ-glycerol methoxytrimethoxysilane film for potential vascular tissue engineering scaffolds.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:35240948] [10.1080/09205063.2022.2046985]
5. Tong Zhang, Biaotong Huang, Ahmed A. Elzatahry, Abdulaziz Alghamdi, Qin Yue, Yonghui Deng.  (2020)  Synthesis of Podlike Magnetic Mesoporous Silica Nanochains for Use as Enzyme Support and Nanostirrer in Biocatalysis.  ACS Applied Materials & Interfaces,      [PMID:32207600] [10.1021/acsami.0c03220]
6. Wang Jianying, Ma Xiaofei, Wei Lai, Dai Guangchao, Zhu Xiang, Zhu Yuhua, Mei Tao, Li Jinhua, Wang Xianbao.  (2017)  Synthesis of a novel kind of uniform fluorescent silica colloids and their assembled photonic film for sensitive detection of Cu2+ ions.  Materials Express,  (5): (351-360).  [PMID:] [10.1166/mex.2017.1391]
7. Qingbo Xu, Jinlong Zhang, Zheng Wu, Supeng Zhang.  (2025)  Fluorine-free and durably superhydrophobic PET fabric for self-cleaning, oil-water separation and anti-icing.  Materials Today Chemistry,      [PMID:] [10.1016/j.mtchem.2025.102756]
Solution Calculators
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