Donepezil HCl - ≥98% , Acetylcholinesterase inhibitor, CAS No.120011-70-3, Acetylcholinesterase inhibitor

CAS: 120011-70-3 Cat. No.: D129948 Molecular Weight: 415.96 EC Number: 620-543-2
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
DONEPEZIL HYDROCHLORIDE [JAN] | DONEPEZIL HYDROCHLORIDE [MI] | s2462 | (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one monohydrochloride | CCG-101043 | Tox21_112534_1 | DTXCID8026698 | E 2020 | EN300-269733 | FT-0602354
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
D129948-250mg
3
$9.90
1g
D129948-1g
2
$10.90
5g
D129948-5g
3
$22.90
25g
D129948-25g
2
$69.90
100g
D129948-100g
2
$232.90
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 21 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
A noncompetitive acetylcholinesterase (AChE) inhibitor.

Specifications

Synonyms
DONEPEZIL HYDROCHLORIDE [JAN] | DONEPEZIL HYDROCHLORIDE [MI] | s2462 | (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5, 6-dimethoxy-2, 3-dihydro-1H-inden-1-one monohydrochloride | CCG-101043 | Tox21_112534_1 | DTXCID8026698 | E 2020 | EN300-269733 | FT-0602354
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
Donepezil Hydrochloride is a noncompetitive acetylcholinesterase inhibitor (IC50 = 11.6 nM. It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain aga
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Mechanism of action
Acetylcholinesterase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Pubchem Sid504750931
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750931
Canonical SmilesCOC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
IUPAC Name2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride
InChIKeyXWAIAVWHZJNZQQ-UHFFFAOYSA-N
INCHI1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
Isomeric SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
WGK Germany 1
RTECS NK8927885
Alternate CAS 110119-84-1
Molecular Weight 415.96
Reaxy-Rn 7062905
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7062905&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassPiperidines
SubclassBenzylpiperidines
Intermediate Tree Nodes Not available
Direct ParentN-benzylpiperidines
Alternative Parents Indanones  Phenylmethylamines  Benzylamines  Aryl alkyl ketones  Anisoles  Aralkylamines  Alkyl aryl ethers  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents N-benzylpiperidine - Indanone - Indane - Anisole - Benzylamine - Phenylmethylamine - Aryl ketone - Aryl alkyl ketone - Alkyl aryl ether - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Tertiary aliphatic amine - Tertiary amine - Ketone - Azacycle - Ether - Amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organonitrogen compound - Organic oxygen compound - Organooxygen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom.
External Descriptors hydrochloride - piperidines - cyclic ketone
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ACHE Tclin Acetylcholinesterase (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Cholinesterases; ACHE & BCHE (1222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot NumberCertificate TypeDateItem
D2412034Certificate of AnalysisJan 21, 2026 D129948
A2604002Certificate of AnalysisDec 15, 2025 D129948
L2509046Certificate of AnalysisDec 15, 2025 D129948
A2608024Certificate of AnalysisDec 15, 2025 D129948
K2301067Certificate of AnalysisAug 11, 2025 D129948
D2313819Certificate of AnalysisJan 13, 2025 D129948
K2426125Certificate of AnalysisNov 15, 2024 D129948
K2408131Certificate of AnalysisNov 15, 2024 D129948
C2507116Certificate of AnalysisNov 15, 2024 D129948
K2428323Certificate of AnalysisApr 02, 2024 D129948
K2425328Certificate of AnalysisApr 02, 2024 D129948
K2119304Certificate of AnalysisSep 15, 2023 D129948
K2119226Certificate of AnalysisSep 15, 2023 D129948
K2119303Certificate of AnalysisSep 15, 2023 D129948
K2119224Certificate of AnalysisSep 15, 2023 D129948
K2116046Certificate of AnalysisSep 13, 2023 D129948
K2115202Certificate of AnalysisAug 21, 2023 D129948
K1709045Certificate of AnalysisMay 10, 2023 D129948
A2125505Certificate of AnalysisNov 16, 2022 D129948
D2412033Certificate of AnalysisNov 04, 2021 D129948

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Chemical and Physical Properties
SolubilitySoluble in water (100 mM), DMSO (1 mg/ml), methanol, ethanol (2 mg/ml), and DMF (slightly).
SensitivityMoisture sensitive
Melt Point(°C)220-222°C
Molecular Weight416.000 g/mol
XLogP3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass415.191 Da
Monoisotopic Mass415.191 Da
Topological Polar Surface Area38.800 Ų
Heavy Atom Count29
Formal Charge0
Complexity510.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Documents & Articles
Citations of This Product
References
1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li.  (2023)  Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:38052155] [10.1016/j.ejmech.2023.116013]
2. Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu.  (2023)  Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37844366] [10.1016/j.jpba.2023.115765]
3. Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han.  (2022)  Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:35304276] [10.1016/j.jep.2022.115194]
4. Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua.  (2022)  Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.  Frontiers in Aging Neuroscience,      [PMID:35126093] [10.3389/fnagi.2021.809433]
5. Li Ying-Qi, Chen Yi, Jiang Si-Qi, Shi Yuan-Yuan, Jiang Xiao-Li, Wu Shan-Shan, Zhou Ping, Wang Hui-Ying, Li Ping, Li Fei.  (2021)  An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease.  Frontiers in Cell and Developmental Biology,      [PMID:34350171] [10.3389/fcell.2021.652310]
6. Liping Zhao, Ge Yang, Linsen Li, Chao Zhu, Yao Ma, Feng Qu.  (2020)  Aptamer-functionalized magnetic nanoparticles conjugated organic framework for immobilization of acetylcholinesterase and its application in inhibitors screening.  ANALYTICA CHIMICA ACTA,      [PMID:33218485] [10.1016/j.aca.2020.10.024]
7. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li.  (2020)  Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:32173426] [10.1016/j.jep.2020.112764]
8. Min Tao, Li Zhang, Yinlong Guo.  (2018)  Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:30159674] [10.1007/s13361-018-2054-3]
9. Mingfei Wu, Jie Ma, Lijun Ji, Min Wang, Jianfei Han, Zeng Li.  (2019)  Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31136894] [10.1016/j.ejmech.2019.05.055]
10. Yue Chen, Hai-Long Wu, Tong Wang, Ru-Qin Yu.  (2024)  A calibration model transfer method based on quadrilinear model for excitation-emission matrix fluorescence measurements on different fluorescence spectrophotometers.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110053]
11. Donglin Xiang, Shuyi Qiu, Laping He, Chun Ji, Jiayu Chen, Yuangen Wu, Han Tao.  (2024)  Purification, characterization of a plant esterase from red kidney bean and its feasibility for pesticide residue analysis in foods.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.103944]
12. Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou.  (2024)  Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway.  NEUROSCIENCE LETTERS,      [PMID:38616003] [10.1016/j.neulet.2024.137769]
13. Yan-Peng Liang, Qian Gao, Hong Chen, Rui Ma, Xiao-Bo Zhao, Xiao-Jie Jin, Jian Zhang, Yan-Ping Shi, Wei Ha.  (2025)  Multi-target directed ligands design of 1-O-Acetylbritannilactone derivatives: Dual anti-neuroinflammatory and acetylcholinesterase inhibitory activities.  Phytochemistry Letters,      [PMID:] [10.1016/j.phytol.2025.103011]
14. Chen Junyang, Xiang Pan, Duro-Castano Aroa, Cai Huawei, Guo Bin, Liu Xiqin, Yu Yifan, Lui Su, Luo Kui, Ke Bowen, Ruiz-Pérez Lorena, Gong Qiyong, Tian Xiaohe, Battaglia Giuseppe.  (2025)  Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport.  Signal Transduction and Targeted Therapy,  10  (1): (1-12).  [PMID:41052971] [10.1038/s41392-025-02426-1]
15. Zhe Wang, Hao-tian Zhang, Si-yue Li, Xiu-ping Song, Chong-zhen Shi, Ye-wen Zhang, Fei Han.  (2025)  An integrative study on the effects of Lingguizhugan decoction in treating Alzheimer's disease rats through modulation of multiple pathways involving various components.  COMPUTERS IN BIOLOGY AND MEDICINE,      [PMID:40228446] [10.1016/j.compbiomed.2025.110149]
16. Che Chen, Qianfeng Shao, Sheng Zhou.  (2025)  Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology.  Frontiers in Aging Neuroscience,      [PMID:41450541] [10.3389/fnagi.2025.1688316]
17. Amel A. Ibrahim, Nancy M. El Halfawy, Yuqi Zhang, Ya Liu, Xirui Zhang, Shuxin Zhou, Jianquan Kan, Muying Du.  (2025)  Development and Genomic Evaluation of a Novel Functional Fermented Milk Formulated with Lactobacillus delbrueckii Strains and Jujuba Kernel Powder for Potential Neuroprotective Effects.  Foods,  14  (24):   [PMID:41473941] [10.3390/foods14244264]
18. Shuai Qin, Yujia Ren, Xuxin Yan, Juan Wang, Hai Yang, Xuemei Zhuang, Rong Wang, Shaojun Dong, Daoqing Fan.  (2025)  Multimodal Biosensors with Flexible-Concentration Adaptability Based on Single-Component Nanozymes for Highly Accurate BChE Analysis and Concatenated Logic Circuit-Programmed Inhibitor Screening.  ANALYTICAL CHEMISTRY,      [PMID:41457628] [10.1021/acs.analchem.5c07159]
19. Yongchang Zeng, Dandan Xu, Xinping Li, Qianqian Jiang, Shaoyu Liang.  (2026)  Dietary dihydroquercetin alleviates age-related cognitive impairment in association with modulation of apoptosis and pyroptosis pathways.  Frontiers in Pharmacology,      [PMID:41710929] [10.3389/fphar.2026.1744898]
20. Zi-Han Xu, Zheng-Biao Zou, Chun-Xiu Wang, Chen Li, Xian-Wen Yang, Jun-Song Wang.  (2026)  Anti-Neuroinflammatory Naphtho-γ-Pyrones from a Deep-Sea-Derived Fungus Aspergillus niger 3A00562.  Marine Drugs,  24  (4): (125).  [PMID:] [10.3390/md24040125]
21. Qiang-Ming Li, Qiao-Qiao Zhang-Yang, Ya-Yi Tan, Xiang-Ling Wu, Xue-Qiang Zha, Zhen-Zi Shang, Jian-Ping Luo, Feng-Yun Zhang.  (2026)  Dendrobium huoshanense stem polysaccharide protects against Alzheimer's disease by modulating SCFAs/GLP-1 axis-mediated neuroinflammation suppression.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:] [10.1016/j.ijbiomac.2026.151235]
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