Fluocinonide - Moligand™, 10mM in DMSO , Glucocorticoid receptor agonist, CAS No.356-12-7, Glucocorticoid receptor agonist

CAS: 356-12-7 Cat. No.: F407947 Molecular Weight: 494.52 EC Number: 206-597-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(6α,​11β,​16α)​-21-​(acetyloxy)​-​6,​9-​difluoro-​11-​hydroxy-​16,​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1,​4-​diene-​3,​20-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Fluocinonide Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
In vitro

Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam.

In vivo

Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

(6α, ​11β, ​16α)​-21-​(acetyloxy)​-​6, ​9-​difluoro-​11-​hydroxy-​16, ​17-​[(1-​methylethylidene)​bis(oxy)​]​-​pregna-​1, ​4-​diene-​3, ​20-​dione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Glucocorticoid receptor agonist

Product Properties

• ALogP: 3.2

Names and Identifiers

• Isomeric SMILES: CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)C=C[C@@]54C)F)F)O)C)OC(O2)(C)C
• WGK Germany: 3
• RTECS: TU3831000
• Molecular Weight: 494.52
• Reaxy-Rn: 26095433
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095433&ln=

Associated Targets(Human)

NR3C1 Tclin Glucocorticoid receptor (3 Activities)

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Yanxia Li, Xiaoman Chen, Ling Xia, Xiaohua Xiao, Gongke Li.  (2019)  Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31353072] [10.1016/j.chroma.2019.460382]