10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Ganciclovir (BW 759) Ganciclovir (RS-21592, BW-759, 2'-Nor-2'-deoxyguanosine) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay.
In vitro
Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase. Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. Ganciclovir-induced apoptosis is due to incorporation of the drug into DNA resulting in replication-dependent formation of DNA double-strand breaks and, at later stages, S and G2/M arrest. Ganciclovir-provoked DNA instability is likely to be responsible for the observed initial decline in Bcl-2 level and caspase-9/-3 activation.
In vivo
Antiviral drug ganciclovir (GCV) inhibits the proliferation of microglia in experimental autoimmune encephalomyelitis (EAE). GCV attenuates neuroinflammation and does not significantly restrain the peripheral immune response.
Cell Data
cell lines：
Concentrations：--
Incubation Time：24 h
Powder Purity:≥99%
| ALogP | -2.5 |
|---|
| Isomeric SMILES | C1=NC2=C(N1COC(CO)CO)N=C(NC2=O)N |
|---|---|
| WGK Germany | 3 |
| RTECS | MF8407000 |
| Molecular Weight | 255.23 |
| Reaxy-Rn | 3654487 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3654487&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 250°C(dec.)(lit.) |
|---|
| 1. Yang Jia, Li Li, Xu Fuqiang, Jia Fan. (2024) Development of a reporter feline herpesvirus-1 for antiviral screening assays. VETERINARY RESEARCH, 55 (1): (1-9). [PMID:39696698] [10.1186/s13567-024-01430-7] |
| 2. Shenjia Huang, Linsheng Liu, Xiaoxue Liu, Lin Song, Chenrong Huang, Liyan Miao. (2022) Development and application of a rapid and sensitive liquid chromatography-mass spectrometry method for simultaneous analysis of cytarabine, cytarabine monophosphate, cytarabine diphosphate and cytarabine triphosphate in the cytosol and nucleus. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:35101802] [10.1016/j.jpba.2022.114582] |
| 3. Lantao Liu, Nan Li, Meijun Chen, Hailin Yang, Qian Tang, Chengbin Gong. (2018) Visible-Light-Responsive Surface Molecularly Imprinted Polymer for Acyclovir through Chicken Skin Tissue. ACS Applied Bio Materials, [PMID:34996176] [10.1021/acsabm.8b00275] |
