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GGTI-2154 hydrochloride - ≥98% , CAS No.478908-50-8
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I) , with an IC 50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer
In Vitro
GGTI-2154 inhibits the transfer of geranylgeranyl from [ 3 H]GGPP to H-Ras CVLL, with an IC 50 of 21 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice. GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60% . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MMTV-v-Ha-ras transgenic mice bearing mammary carcinomaDosage: 100 mg/kg/day Administration: S.c. with osmotic mini-pumps for 14 days Result: Halted the tumors aggressive growth. Resulted in rapid tumor regression within 3 days of initiation of drug treatment.
Form:Solid
IC50& Target:IC50: 21 nM (GGTase I)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I) , with an IC 50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can b
Storage
Store at 2-8°C, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Molecular Weight | 456.97 |
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Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 250 mg/mL (547.08 mM; Need ultrasonic) H2O : 4.76 mg/mL (10.42 mM; ultrasonic and warming and heat to 60°C) |
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Solution Calculators
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