GSK 1562590 hydrochloride - ≥98%(HPLC) , CAS No.1003878-07-6

CAS: 1003878-07-6 Cat. No.: G287869 Molecular Weight: 617.95 PubChem CID: 46909864

GRADE & PURITY ≥98%(HPLC)

Synonyms

N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

N-[(1R)-1-[3'-(Aminocarbonyl)[1, 1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6, 7-dichloro-2, 3-dihydro-N-methyl-3-oxo-4H-1, 4-benzoxazine-4-acetamide hydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

High affinity and selective urotensin II (UT) receptor antagonist (pKivalues are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion cha

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CN(C(CN1CCCC1)C2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)N)C(=O)CN4C(=O)COC5=CC(=C(C=C54)Cl)Cl.Cl
• IUPAC Name: 3-[4-[(1R)-1-[[2-(6,7-dichloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenyl]benzamide;hydrochloride
• InChIKey: XTVXEMMIPYMBLL-SNYZSRNZSA-N
• INCHI: 1S/C30H30Cl2N4O4.ClH/c1-34(28(37)17-36-25-14-23(31)24(32)15-27(25)40-18-29(36)38)26(16-35-11-2-3-12-35)20-9-7-19(8-10-20)21-5-4-6-22(13-21)30(33)39;/h4-10,13-15,26H,2-3,11-12,16-18H2,1H3,(H2,33,39);1H/t26-;/m0./s1
• Isomeric SMILES: CN([C@@H](CN1CCCC1)C2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)N)C(=O)CN4C(=O)COC5=CC(=C(C=C54)Cl)Cl.Cl
• PubChem CID: 46909864
• Molecular Weight: 617.95

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 61.8, Max Conc. mM: 100