10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC 50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity
In Vitro
GSK805 (0.5 μM; 4 d) inhibits Th17 cell responses. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Differentiation AssayCell Line: CD4 + T cells Concentration: 0.5 μM Incubation Time: 4 days Result: Inhibited IL-17 production during Th17 cell differentiation.
In Vivo
GSK805 (10 mg/kg; p.o. once per day for 35 days) improves the situation of mice with experimental autoimmune encephalomyelitis (EAE). GSK805 (30 mg/kg; p.o. once) inhibits Th17 cell responses in EAE mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice were immunized with MOG35–55 plus CFADosage: 10 mg/kg Administration: Oral gavage; 10 mg/kg once per day; for 35 days Result: Efficiently ameliorated the severity of EAE in mice. Animal Model: C57BL/6 mice with EAEDosage: 30 mg/kg Administration: Oral gavage; 30 mg/kg once Result: Reduced both IFN-γ - IL-17 + and IFN-γ + IL-17 + T cells without altered the frequency of TNF-α + T cells in EAE mice.
IC50& Target:IC50: 8.4 (RORγt)
| Isomeric SMILES | CCS(=O)(=O)C1=CC=C(C=C1)CC(=O)NC2=CC(=C(C(=C2)Cl)C3=CC=CC=C3OC(F)(F)F)Cl |
|---|---|
| PubChem CID | 71285927 |
| Molecular Weight | 532.4 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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