Guan-fu base A - ≥98% , CAS No.1394-48-5

CAS: 1394-48-5 Cat. No.: G302802 Molecular Weight: 429.51 PubChem CID: 101603171

GRADE & PURITY ≥98%

Synonyms

Acehytisine; Kwan-fu base A; (2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview

product description：

Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes. Guanfu base A also inhibits HERG channel current.

Specifications

Synonyms

Acehytisine; Kwan-fu base A; (2alpha, 11alpha, 13R)-Hetisan-2, 11, 13, 14-tetrol 2, 13-diacetate

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504772770
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772770
• Canonical Smiles: CC(=O)OC1CC2(CN3C4C2C5(C1)C3C6(C(C7C(C5C6(C4)CC7=C)O)OC(=O)C)O)C
• IUPAC Name: [(1S,3S,5S,8S,9R,11R,14R,16S,17R,18S,19S)-10-acetyloxy-9,19-dihydroxy-5-methyl-12-methylidene-7-azaheptacyclo[9.6.2.01,8.05,17.07,16.09,14.014,18]nonadecan-3-yl] acetate
• InChIKey: OGNUSOJAYIHLNS-CGMBEVFJSA-N
• INCHI: 1S/C24H31NO6/c1-10-5-22-8-14-17-21(4)6-13(30-11(2)26)7-23(17)18(22)16(28)15(10)19(31-12(3)27)24(22,29)20(23)25(14)9-21/h13-20,28-29H,1,5-9H2,2-4H3/t13-,14-,15+,16+,17+,18+,19?,20-,21+,22+,23-,24-/m0/s1
• Isomeric SMILES: CC(=O)O[C@H]1C[C@@]2(CN3[C@@H]4[C@H]2[C@]5(C1)[C@H]3[C@]6(C([C@H]7[C@H]([C@@H]5[C@]6(C4)CC7=C)O)OC(=O)C)O)C
• PubChem CID: 101603171
• Molecular Weight: 429.51

Chemical and Physical Properties

• Sensitivity: Moisture sensitive；Light sensitive