≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 , with a p IC 50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity.
In Vitro
GW768505A free base has inhibition for cancer cells growth in NCI-60 panel screening. GW768505A free base is an inhibitor of KDR and TIE2, shows potent inhibition (71–88% inhibition at 100 nM) of the tropomysin-related kinases TRKA, TRKB and TRKC. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:KDR Tie2 Tie-2
| Canonical Smiles | COC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3O2)N)C4=CC=C(C=C4)NC(=O)NC5=C(C=CC(=C5)C(F)(F)F)F |
|---|---|
| IUPAC Name | 1-[4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| InChIKey | FGZIONRFHVNRJB-UHFFFAOYSA-N |
| INCHI | 1S/C27H19F4N5O3/c1-38-18-9-4-15(5-10-18)23-21(22-24(32)33-13-34-25(22)39-23)14-2-7-17(8-3-14)35-26(37)36-20-12-16(27(29,30)31)6-11-19(20)28/h2-13H,1H3,(H2,32,33,34)(H2,35,36,37) |
| Isomeric SMILES | COC1=CC=C(C=C1)C2=C(C3=C(N=CN=C3O2)N)C4=CC=C(C=C4)NC(=O)NC5=C(C=CC(=C5)C(F)(F)F)F |
| PubChem CID | 5326956 |
| Molecular Weight | 573.93 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Furans |
| Subclass | Diphenylfurans |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 2,3-diphenylfurans |
| Alternative Parents | Trifluoromethylbenzenes N-phenylureas Furo[2,3-d]pyrimidines Phenoxy compounds Anisoles Methoxybenzenes Alkyl aryl ethers Aminopyrimidines and derivatives Fluorobenzenes Primary aromatic amines Aryl fluorides Imidolactams Heteroaromatic compounds Ureas Oxacyclic compounds Azacyclic compounds Alkyl fluorides Organic oxides Organofluorides Organopnictogen compounds Carbonyl compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 2,3-diphenylfuran - Trifluoromethylbenzene - N-phenylurea - Furo[2,3-d]pyrimidine - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Aminopyrimidine - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Primary aromatic amine - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Urea - Oxacycle - Azacycle - Ether - Organopnictogen compound - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organofluoride - Carbonyl group - Alkyl halide - Alkyl fluoride - Organic nitrogen compound - Primary amine - Amine - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 2,3-diphenylfurans. These are organic heterocyclic compounds that contain a furan ring substituted with a phenyl group only the C2- and C3-positions. |
| External Descriptors | organofluorine compound - ureas - furopyrimidine |
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| Molecular Weight | 537.500 g/mol |
|---|---|
| XLogP3 | 5.400 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 5 |
| Exact Mass | 537.142 Da |
| Monoisotopic Mass | 537.142 Da |
| Topological Polar Surface Area | 115.000 Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 0 |
| Complexity | 822.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
