10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 10 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2.
In vitro
Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor). Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst. Histamine and interleukin-2 (IL-2) act synergistically to activate NK cell cytotoxicity (NKCC). Histamine combined with IL-2 might improve response rates and disease-free survival by protecting the cells of the immune system from oxidative stress and inducing natural endogenous immune cytotoxicity.
In vivo
Histamine treatment (0.5 mg/kg or 5.0 mg/kg, twice daily) protects against liver injury as evident by normal serum transaminase levels and significantly reduced liver pathology scores in a rat model with early alcohol-induced liver injury. The protective effect of histamine is blocked by Ranitidine (10 mg/kg), an H2 receptor antagonist, indicating that the histamine effect is predominantly mediated through the H2 receptor. Histamine (30 pg/rat, icv) increases both 3,4-dihydroxyphenylalanine accumulation and 3,4-dihydroxyphenylalanine acid concentrations in the nucleus accumbens in male rats, and this effect is not affect by H2 antagonist zolantidine, indicating that histamine stimulates mesolimbic DA neurons through an action at the H1 receptor. Histamine (0.5 mg/kg s.c.) reduces the liver tumour weight by 46% and subcutaneous tumour weight by 41% versus rats receiving subcutaneous saline injections. The anti-tumour effect observed by subcutaneous histamine injections is inhibited by Ranitidine (50 mg/kg s.c.) in rats sarcoma. Histamine (1000 mg/kg s.c.) displays acute tissue damage after 24 hours and indications of pathological inflammation at the injection sites at 5 days and 28 days in Sprague-Dawley rats. Histamine (1000 mg/kg s.c.) results in Cmax of 167 mM, tmax of 0.5 hour, t1/2 of 0.95 and AUC of 186 mmol-h/L in male Sprague-Dawley rats.
Cell Data
cell lines：Leukemia L1210 cell
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | C1=C(NC=N1)CCN.Cl.Cl |
|---|---|
| WGK Germany | 2 |
| RTECS | MS1575000 |
| PubChem CID | 5818 |
| Molecular Weight | 184.07 |
| Beilstein | 3624116 |
| Reaxy-Rn | 3624116 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 52 mg/mL warmed with 50ºC Water: bath (187.46 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Melt Point(°C) | 246°C |
| 1. Cheng-yuan Li, Mei Su, Yun-yi Yan, Lin Zhou, Lu-yao Ao, Wei-rong Fang, Yun-man Li. (2017) KFP-H008 blocks gastric acid secretion through inhibiting H+-K+-ATPase. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:28629736] [10.1016/j.ejphar.2017.06.020] |
| 2. Shijin Xiong, Xiaoyan Xu, Qiaozhen Liu, Yazhou Xu, Hongbing Ren, Tao Xiong, Mingyong Xie. (2023) Integrated metatranscriptomics and metabolomics revealed the metabolic pathways of biogenic amines during Laotan Suancai fermentation. Food Bioscience, [PMID:] [10.1016/j.fbio.2023.103517] |
| 3. Furong Jin, Xinyue Yin, Yang Wan, Jiukai Zhang, Jindi Wang, Xiangbo Fu, Tianxin Fu, Buwei Liu, Yongshi Chen, Bo Tian, Zhibiao Feng. (2023) Ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction of trace biogenic amines in fish and beer based on solidification of floating organic droplet. FOOD CHEMISTRY, [PMID:37516607] [10.1016/j.foodchem.2023.136965] |
| 4. Shan Xu, Peifang Chen, Xichi Lin, Imran Mahmood Khan, Xiaoyuan Ma, Zhouping Wang. (2022) Controllable synthesis of flower-like AuNFs@ZIF-67 core-shell nanocomposites for ultrasensitive SERS detection of histamine in fish. ANALYTICA CHIMICA ACTA, [PMID:36641156] [10.1016/j.aca.2022.340776] |
| 5. Jian-Jun Zhong, Liping Xia, Liuru Xue, Boyu Liu, Lingling Zhao, Hua Ye, Zhanming Li. (2022) Analytical method for histamine, urocanic acid isomers, and their precursor histidine in fish sauce based on precolumn dansylation and high-performance liquid chromatography. FOOD CONTROL, [PMID:] [10.1016/j.foodcont.2022.109566] |
| 6. Yixuan Fan, Runze Yu, Yongfeng Chen, Yufeng Sun, Geoffrey I. N. Waterhouse, Zhixiang Xu. (2022) A Capillary Electrophoresis Method Based on Molecularly Imprinted Solid-Phase Extraction for Selective and Sensitive Detection of Histamine in Foods. MOLECULES, 27 (20): (6987). [PMID:36296580] [10.3390/molecules27206987] |
| 7. Xirui Chen, Yujie Tu, Song Cheng, Xujing Guo, Tianying Lu, Yuqian Guo, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang. (2022) A colorimetric and ratiometric fluorescent paper chip for biogenic amine monitoring based on a simple pH-sensitive AIEgen. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.137928] |
| 8. Xujing Guo, Xirui Chen, Rui Chen, Yujie Tu, Tianying Lu, Yuqian Guo, Liang Guo, Yonghua Xiong, Xiaolin Huang, Ben Zhong Tang. (2022) Ratiometric Monitoring of Biogenic Amines by a Simple Ammonia-Response Aiegen. Foods, 11 (7): (932). [PMID:35407018] [10.3390/foods11070932] |
| 9. Xiaofeng Wang, Yongfeng Chen, Runze Yu, Ruiqiang Wang, Zhixiang Xu. (2021) A sensitive biomimetic enzyme-linked immunoassay method based on Au@Pt@Au composite nanozyme label and molecularly imprinted biomimetic antibody for histamine detection. FOOD AND AGRICULTURAL IMMUNOLOGY, [PMID:] [10.1080/09540105.2021.1978945] |
| 10. Chen Chen, Ximo Wang, Geoffrey I.N. Waterhouse, Xuguang Qiao, Zhixiang Xu. (2021) A surface-imprinted surface-enhanced Raman scattering sensor for histamine detection based on dual semiconductors and Ag nanoparticles. FOOD CHEMISTRY, [PMID:34488130] [10.1016/j.foodchem.2021.130971] |
| 11. Yiming Zhang, Jinsheng Yu, Shuyu Lai, Jian Song, Xiaomei Wu, Dingnan Wang, Linjiang Pang, Tingting Chai. (2020) Rapid determination of histamine level in seafood using read-out strips based on high-performance thin layer chromatography modified with self-visualization nanomaterials. FOOD CONTROL, [PMID:] [10.1016/j.foodcont.2020.107816] |
| 12. Yi-Fang Li, Zheng-Zhong Lin, Cheng-Yi Hong, Zhi-Yong Huang. (2020) Histamine detection in fish samples based on indirect competitive ELISA method using iron-cobalt co-doped carbon dots labeled histamine antibody. FOOD CHEMISTRY, [PMID:33601655] [10.1016/j.foodchem.2020.128812] |
| 13. Xiaofeng Wang, Xiaoqing Song, Lin Si, Longhua Xu, Zhixiang Xu. (2020) A novel biomimetic immunoassay method based on Pt nanozyme and molecularly imprinted polymer for the detection of histamine in foods. FOOD AND AGRICULTURAL IMMUNOLOGY, [PMID:] [10.1080/09540105.2020.1807916] |
| 14. Yangyang Xu, Suya Fu, Feiyang Liu, Haiyin Yu, Jiangang Gao. (2018) Multi-stimuli-responsiveness of a novel polydiacetylene-based supramolecular gel. Soft Matter, 14 (39): (8044-8050). [PMID:30255918] [10.1039/C8SM01515E] |
| 15. Lingling Zhao, Xinqi Pan, Jie Shi, Hua Ye, Huanan Guan, Yuanxin Guo, Jian-Jun Zhong. (2025) Formation of urocanic acid versus histamine from histidine in chub mackerel (Scomber japonicus) fillets as determined by a mixed-mode HPLC method. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2025.107431] |
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| 18. Jinxiu Guo, Yu Chen, Lizhi Zhao, Ping Sun, Hongli Li, Lei Zhou, Xiayan Wang, Qiaosheng Pu. (2016) A strategy to modulate the electrophoretic behavior in plastic microchips using sodium polystyrene sulfonate. JOURNAL OF CHROMATOGRAPHY A, [PMID:27908499] [10.1016/j.chroma.2016.11.042] |
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| 21. Zehao Ye, Jiying Xu, Yi Chen, Pengfei Zhang. (2026) Electrochemically Modulated Optical Imaging Sensors Integrated with Microfluidics. Biosensors-Basel, 16 (2): (86). [PMID:41744705] [10.3390/bios16020086] |
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