Iniparib (BSI-201) - Moligand™, 10mM in DMSO , Reactive nitro radical, CAS No.160003-66-7, Reactive nitro radical

CAS: 160003-66-7 Cat. No.: I409033 Molecular Weight: 292.03 EC Number: 685-396-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

NSC-746045, IND-71677 | 4-iodo-3-nitrobenzamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Iniparib (BSI-201, NSC-746045, IND-71677) is aPARP1inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.
In vitro

BSI-201 is described as a prodrug of 4-iodo-3-nitrosobenzamide, an agent that covalently inhibits PARP1 by binding to its first zinc finger under cell-free conditions. Treatment of 120 μM BSI-201 plus buthionine sulfoximine (BSO) induces a 95% cell death among 855-2 cells, and displays a similar effect in other human cancer cells. BSI-201 inhibits the growth of E-ras 20 cells, the effect of which can be augmented 4-fold when BOS is added. Recently BSI-201 shows no ability to inhibit PARP enzymatic or cellular activity, but can non-selectively modify cysteine-containing proteins in tumor cells, suggesting the mechanism of action for BSI-201 is likely not via inhibition of PARP activity. BSI-201 (100 μM) inhibits ionizing radiation-induced single-strand breaks (SSBs) repair in human lymphoid cell lines based on large endogenous Epstein–Barr virus (EBV) circular episomes assay, resulting in 55% repair by 2 hours, which can be reversed surprisingly by knockdown of PARP1, indicating that the mechanism of inhibition does not involve trapping PARP at SSBs. BSI-201 is not able to selectively kill homologous recombination (HR)-deficient cells between BRCA2-deficient PEO1 and BRCA2-revertant PEO4, or ATM-deficient GM16666 and ATM-restored GM16667 fibroblasts. BSI-201 is cytotoxic to a variety of cell lines at concentrations above 40 μM reflecting a mechanism independent of PARP.

In vivo

Cell Data

cell lines：

Concentrations：Dissolved in DMSO, final concentrations ~10 μM

Incubation Time：5, and 9 days

Powder Purity:≥99%

Specifications

Synonyms

NSC-746045, IND-71677 | 4-iodo-3-nitrobenzamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Iniparib (BSI-201, NSC-746045, IND-71677) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). Phase 3.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Reactive nitro radical

Product Properties

• ALogP: 1.3

Names and Identifiers

• Isomeric SMILES: C1=CC(=C(C=C1C(=O)N)[N+](=O)[O-])I
• WGK Germany: 3
• Molecular Weight: 292.03
• Reaxy-Rn: 7704659
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7704659&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL warmed with 50ºC Water: bath (152.14 mM); Ethanol: 2 mg/mL warmed with 50ºC Water: bath (4.9 mM); Water: Insoluble

References

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