10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Isoprenaline HCl (NCI-C55630) is a non-selectivebeta-adrenergic receptoragonist, used for the treatment of bradycardia and heart block.
In vitro
Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells. [1] Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity. [2] Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO). [3] Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged. [4] Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells. [5]
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥97%
| Isomeric SMILES | CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl |
|---|---|
| WGK Germany | 2 |
| RTECS | DO1925000 |
| Molecular Weight | 247.72 |
| Beilstein | 3917363 |
| Reaxy-Rn | 3917363 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3917363&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 33 mg/mL (199.72 mM); |
|---|---|
| Melt Point(°C) | 165-175℃ |
| 1. Jia Sun, Rong Li, Jingya Zhang, Yong Huang, Yuan Lu, Chunhua Liu, Yongjun Li, Ting Liu. (2023) Analysis of compatibility mechanism of shenxiong glucose injection after multiple dosing based on differences of PK-PD correlation and cytochrome P450 enzyme. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:38103414] [10.1016/j.jpba.2023.115899] |
| 2. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2023) Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway. FITOTERAPIA, [PMID:38007052] [10.1016/j.fitote.2023.105756] |
| 3. Yong-Yu Yang, Jing-Jing Qi, Si-Yi Jiang, Ling Ye. (2023) Esculin ameliorates obesity-induced insulin resistance by improving adipose tissue remodeling and activating the IRS1/PI3K/AKT/GLUT4 pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37778516] [10.1016/j.jep.2023.117251] |
| 4. Qianlong Wang, Tiantian Wang, Chonkit Lio, Xina Yu, Xiaoyi Chen, Lancong Liu, Youjiao Wu, Hui Huang, Linsen Qing, Pei Luo. (2023) Surface hydrolysis-designed AuNPs-zwitterionic-glucose as a novel tool for targeting macrophage visualization and delivery into infarcted hearts. JOURNAL OF CONTROLLED RELEASE, [PMID:36898530] [10.1016/j.jconrel.2023.03.008] |
| 5. Xuping Li, Shuotao Shi, Ying Yang, Yanmei Lou, Sixuan Chen, Yixin Guo, Xiaoxiao Qi, Ying Wang, Zhongqiu Liu, Yuanyuan Cheng. (2022) The anticardiac fibrosis of total alkaloids of Plumula nelumbinis by regulating circulating lipidomic profile: In vivo study. JOURNAL OF FOOD BIOCHEMISTRY, 46 (8): (e14194). [PMID:35502470] [10.1111/jfbc.14194] |
| 6. Renren Sun, Haixia He, Lei Yuan, Jiao Sha, Liyuan Li, Zidan Cao, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) dl-isoprenaline hydrochloride solubility in four binary solvents at saturation: Thermodynamic analysis, Hansen solubility parameters and molecular simulation. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2021.118066] |
| 7. Renren Sun, Haixia He, Lei Yuan, Yameng Wan, Jiao Sha, Liyuan Li, Gaoliang Jiang, Yu Li, Tao Li, Baozeng Ren. (2021) Thermodynamic analysis and molecular simulation of solid–liquid phase equilibrium of isoprenaline hydrochloride in eleven pure solvents at saturation. JOURNAL OF CHEMICAL THERMODYNAMICS, [PMID:] [10.1016/j.jct.2021.106411] |
| 8. Wang Qian-Long, Huang Wei-Xue, Zhang Pu-Juan, Chen Li, Lio Chon-Kit, Zhou Hua, Qing Lin-Sen, Luo Pei. (2019) Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic. MICROCHIMICA ACTA, 187 (1): (1-11). [PMID:31853650] [10.1007/s00604-019-4035-z] |
| 9. Zhenhuang Shen, Qianqian Geng, Haibo Huang, Hong Yao, Tianyu Du, Lifu Chen, Zhenhong Wu, Xiaoqing Miao, Peiying Shi. (2019) Antioxidative and Cardioprotective Effects of Schisandra chinensis Bee Pollen Extract on Isoprenaline-Induced Myocardial Infarction in Rats. MOLECULES, 24 (6): (1090). [PMID:30897711] [10.3390/molecules24061090] |
| 10. Chen Jia, Li Yunchun, Huang Yanni, Zhang Haijuan, Chen Xingguo, Qiu Hongdeng. (2019) Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS2 quantum dots and MoS2 nanosheets. MICROCHIMICA ACTA, 186 (2): (1-9). [PMID:30617543] [10.1007/s00604-018-3143-5] |
| 11. Ling Zhu, Guanhong Xu, Quan Song, Tang Tang, Xu Wang, Fangdi Wei, Qin Hu. (2016) Highly sensitive determination of dopamine by a turn-on fluorescent biosensor based on aptamer labeled carbon dots and nano-graphite. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2016.03.084] |
| 12. Li-Wei Liu, Meng Tang, Zhi-Bo Zhang, Pei-Pei Zhou, Lian-Ping Xue, Qing-Quan Jia, Ling-Guo Zhao, Li-Hua Zuo, Zhi Sun. (2024) A stepwise integrated strategy to explore quality markers of Qishen Yiqi dripping pills against myocardial ischemia. PHYTOMEDICINE, [PMID:39488103] [10.1016/j.phymed.2024.156182] |
| 13. Li Lingling, Zhang Xinru, Chang Xianglei, Meng Xianhua, Wang Weifeng, Zhang Ying, Yang Aimei, Yang Junli. (2025) A synchronous fluorescence biosensor mediated by hydrogen-bonding interaction for highly selective detection of dopamine. MICROCHIMICA ACTA, 192 (3): (1-12). [PMID:39954106] [10.1007/s00604-025-06993-6] |
| 14. Li Yang, Ru Liu, Chaodan Li, Boning Gu, Jiannong Ye, Li Chen, Qingcui Chu. (2024) Chiral zeolite beta used as stationary phase for enantioseparation in miniaturized open tubular capillary electrochromatography with amperometric detection. ANALYTICA CHIMICA ACTA, [PMID:38309852] [10.1016/j.aca.2024.342242] |
| 15. Jiahao Ye, Ruiping Yang, Lin Li, Senjie Zhong, Ruixue Jiang, Zhixi Hu. (2024) Molecular mechanism of Danxiong Tongmai Granules in treatment of coronary heart disease. Aging-US, [PMID:38775721] [10.18632/aging.205845] |
| 16. Zhiqin Liu, Yufeng Xu, Wei Liu, Lin Wang, Zhen Dong, Jianguo Zeng. (2025) Macleaya cordata protopine total alkaloids as potential treatment for diarrhoea: Mechanistic insights and target identification. RESEARCH IN VETERINARY SCIENCE, [PMID:40184723] [10.1016/j.rvsc.2025.105633] |
| 17. Zizheng Wu, Xing Chen, Jiahao Ye, Xiaoyi Wang, Zhixi Hu. (2025) Pericarpium Trichosanthis Injection Protects Isoproterenol-Induced Acute Myocardial Ischemia via Suppressing Inflammatory Damage and Apoptosis Pathways. Biomolecules, 15 (5): (618). [PMID:40427511] [10.3390/biom15050618] |
| 18. Tao Liang, Zhekun Jia, Chengyun Wang, Jiaru Fang, Dongxin Xu, Hao Wang, Ling Zou, Zhen Wang, Ning Hu. (2026) Cardiomyocyte Mechanical Contraction Sensitivity-Enhanced Biosensing for Precise Drug Evaluation. BIOSENSORS & BIOELECTRONICS, [PMID:41558344] [10.1016/j.bios.2026.118405] |
| 19. Xiaoxing Jin, Yuxi Huang, Liyun Luo, Wenyi Tang, Tou Kun Chong, Cunxue Pan, Kan Liu, Jian Chen. (2026) Auricular Vagus Nerve Stimulation Alleviates Cardiac Dysfunction in Takotsubo Syndrome by Inhibiting Excessive Activation of the Sympathetic Nerve System and Inflammation. Translational Research, [PMID:41687733] [10.1016/j.trsl.2026.02.004] |
| 20. Li-Hua Zuo, Sheng-Jie Yang, Zhi-Bo Zhang, Chen-Han He, Yu-Jie Wei, Ya-Ran An, Song-Feng Zhao, Zhi Sun, Li-Wei Liu. (2026) Exploring the mechanisms of Gualou Xiebai Banxia decoction against myocardial ischemia by integrating network pharmacology, metabolomics, lipidomics, and experimental validation. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:] [10.1016/j.jep.2026.121879] |
