Ivaltinostat formic - ≥99% , CAS No.I658991

CAS: I658991 Cat. No.: I658991 Molecular Weight: 473.56

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Ivaltinostat (CG-200745) formic is an orally active, potent pan- HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic

Appearance:Oil

IC50& Target:HDAC

In Vitro:Ivaltinostat (CG-200745; 0.01-100 μM; 48 hours) formic inhibits growth of prostate cancer cells (LNCaP, DU145 and PC3 cells). Ivaltinostat (1, 10 μM; 24, 48 hours) formic increases sub-G1 population, and activates caspase-9, -3 and -8. Ivaltinostat (

In Vivo:Ivaltinostat (CG-200745; p.o.; 30mg/kg/day; for 7 days) formic attenuates oxidative stress, inflammatory cytokines, and adhesion molecules in UUO kidneys. MCE has not independently confirmed the accuracy of these methods. They are for reference only

Biological Activity:Ivaltinostat (CG-200745) formic is an orally active, potent pan- HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic

Specifications

Specifications & Purity

≥99%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 473.56

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (105.58 mM; Need ultrasonic) H2O : 50 mg/mL (105.58 mM; Need ultrasonic)