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L-689,560 - Moligand™, ≥99%(HPLC) , Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D, CAS No.139051-78-8, Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D

CAS: 139051-78-8 Cat. No.: L287337 Molecular Weight: 380.23
COA
L-689,560 - Moligand™, ≥99%(HPLC) CAS No(139051-78-8) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%(HPLC)
Synonyms
AKOS030228809 | BRD-A28422058-001-01-0 | HMS3266P09 | SCHEMBL1993880 | L-689,560 | 4-[[anilino(oxo)methyl]amino]-5,7-dichloro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid | 5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic ac
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
1mg
L287337-1mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
5mg
L287337-5mg
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$279.90
10mg
L287337-10mg
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$436.90
25mg
L287337-25mg
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50mg
L287337-50mg
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$1,464.90
100mg
L287337-100mg
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$1,840.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews
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Why this grade

Moligand™, ≥99%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist that inhibits GluN1 glycine binding sites. L-689560 is widely used as a radiolabeling ligand in binding studies, as well as to study the role of NMDA receptors in normal nervous system processes and diseases

Specifications

Synonyms
AKOS030228809 | BRD-A28422058-001-01-0 | HMS3266P09 | SCHEMBL1993880 | L-689, 560 | 4-[[anilino(oxo)methyl]amino]-5, 7-dichloro-1, 2, 3, 4-tetrahydroquinoline-2-carboxylic acid | 5, 7-dichloro-4-(phenylcarbamoylamino)-1, 2, 3, 4-tetrahydroquinoline-2-carboxylic ac
Specifications & Purity
Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms
Very potent antagonist at the glycine-NMDA site.
Storage
Room temperature
Shipped In
Normal
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of GluN1;Antagonist of GluN2A;Antagonist of GluN2B;Antagonist of GluN2C;Antagonist of GluN2D
Purity
≥99%(HPLC)
Names and Identifiers
Canonical SmilesC1C(C2=C(C=C(C=C2Cl)Cl)NC1C(=O)O)NC(=O)NC3=CC=CC=C3
IUPAC Name5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
InChIKeyUCKHICKHGAOGAP-UHFFFAOYSA-N
INCHI1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)
Isomeric SMILES C1C(C2=C(C=C(C=C2Cl)Cl)NC1C(=O)O)NC(=O)NC3=CC=CC=C3
Molecular Weight 380.23
Reaxy-Rn 8938021
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8938021&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassQuinolines and derivatives
SubclassQuinoline carboxylic acids
Intermediate Tree Nodes Not available
Direct ParentQuinoline carboxylic acids
Alternative Parents Alpha amino acids  N-phenylureas  Hydroquinolines  Secondary alkylarylamines  Aralkylamines  Aryl chlorides  Ureas  Amino acids  Monocarboxylic acids and derivatives  Azacyclic compounds  Carboxylic acids  Organochlorides  Organopnictogen compounds  Carbonyl compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinoline-2-carboxylic acid - Alpha-amino acid - Alpha-amino acid or derivatives - N-phenylurea - Tetrahydroquinoline - Aralkylamine - Secondary aliphatic/aromatic amine - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Amino acid or derivatives - Carbonic acid derivative - Amino acid - Urea - Carboxylic acid - Carboxylic acid derivative - Azacycle - Monocarboxylic acid or derivatives - Secondary amine - Organic nitrogen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Amine - Organic oxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2A Tclin Glutamate receptor ionotropic, NMDA 2A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRIN2D Tclin Glutamate receptor ionotropic, NMDA 2D (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilitySolvent:DMSO, Max Conc. mg/mL: 9.51, Max Conc. mM: 25; Solvent:ethanol, Max Conc. mg/mL: 38.02, Max Conc. mM: 100
Molecular Weight380.200 g/mol
XLogP33.500
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass379.049 Da
Monoisotopic Mass379.049 Da
Topological Polar Surface Area90.500 Ų
Heavy Atom Count25
Formal Charge0
Complexity502.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Solution Calculators
Reviews

Customer Reviews

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