L-Glutamic acid monosodium salt hydrate - PharmPure™, ChP, FCC, NF, E 621, used for L-Glutamic acid monosodium salt hydrate has been used: to prepare glutamate stock solution in HEPES-buffered saline (HBS) for glutamate perfusions. As a component in YNG (

CAS: 6106-04-3 Cat. No.: GMP1527732 Molecular Weight: 187.13 Beilstein Registry Number: 4164348 EC Number: 612-072-6

GRADE & PURITY PharmPure™, ChP, FCC, NF, E 621

Storage

Room temperature

Shipped In

Normal

Overview

L-Glutamic acid/monosodium glutamate (MSG) is the sodium salt of glutamic acid. It is a commonly used food additive.

Specifications

Specifications & Purity

PharmPure™, ChP, FCC, NF, E 621

Biochemical and Physiological Mechanisms

Monosodium glutamate (MSG) is a food additive and an environmental agent, that can affect inflammation. Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

Application

L-Glutamic acid monosodium salt hydrate has been used: to prepare glutamate stock solution in HEPES-buffered saline (HBS) for glutamate perfusions. As a component in YNG (yeast nitrogen base glutamate) medium. Used to treat HT22 hippocampal cells to study

Storage

Room temperature

Shipped In

Normal

Grade

ChP, E 621, FCC, NF, PharmPure™

Names and Identifiers

• Canonical Smiles: C(CC(=O)[O-])C(C(=O)O)N.O.[Na+]
• IUPAC Name: sodium;(4S)-4-amino-5-hydroxy-5-oxopentanoate;hydrate
• InChIKey: GJBHGUUFMNITCI-QTNFYWBSSA-M
• INCHI: 1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1
• Isomeric SMILES: C(CC(=O)[O-])[C@@H](C(=O)O)N.O.[Na+]
• WGK Germany: 2
• RTECS: MA1575000
• Alternate CAS: 142-47-2;32221-81-1
• Molecular Weight: 187.13
• Beilstein: 4164348
• Reaxy-Rn: 4164348

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Glutamic acid and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Glutamic acid and derivatives
• Alternative Parents: L-alpha-amino acids Amino fatty acids Dicarboxylic acids and derivatives Carboxylic acid salts Amino acids Carboxylic acids Organic zwitterions Organic sodium salts Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Glutamic acid or derivatives - Alpha-amino acid - L-alpha-amino acid - Amino fatty acid - Dicarboxylic acid or derivatives - Fatty acid - Fatty acyl - Carboxylic acid salt - Amino acid - Carboxylic acid - Organic alkali metal salt - Organic salt - Organic zwitterion - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Organic sodium salt - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water.
• Specific Rotation[α]: 25 ° (C=10, 2mol/L HCl)
• Melt Point(°C): 232 °C (dec.) (lit.)
• Molecular Weight: 187.130 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 187.046 Da
• Monoisotopic Mass: 187.046 Da
• Topological Polar Surface Area: 104.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 149.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Furong Jin, Xinyue Yin, Yang Wan, Jiukai Zhang, Jindi Wang, Xiangbo Fu, Tianxin Fu, Buwei Liu, Yongshi Chen, Bo Tian, Zhibiao Feng.  (2023)  Ultrasonic–microwave synergistic supramolecular solvent liquid–liquid microextraction of trace biogenic amines in fish and beer based on solidification of floating organic droplet.  FOOD CHEMISTRY,      [PMID:37516607] [10.1016/j.foodchem.2023.136965]

2. Hongtong Hu, Yuyan Chang, Zhongjie Wang, Jiandong Cui, Shiru Jia, Yingjie Du.  (2023)  A chemo-biocatalyst based on glutamate oxidase-integrated biomimetic trimanganese tetraoxide as cascade composite nano-catalyst for synthesis of α‑Ketoglutaric acid.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:37515973] [10.1016/j.jcis.2023.07.137]

3. Yu Miao, Chen Zhuoming, Xin Binjie, Liu Xunlin, Xu Wenjun.  (2022)  Multifunctional Polyacrylonitrile-based Pearl Nanofibrous Membrane Prepared by Electrospinning.  FIBERS AND POLYMERS,  23  (11): (3022-3027).  [PMID:] [10.1007/s12221-022-0059-9]

4. Jing Liu, Ninglong Zhang, Jiansen Li, Mingyang Li, Guangxian Wang, Wenli Wang, Yuxia Fan, Shui Jiang, Gaole Chen, Yin Zhang, Xia Sun, Yuan Liu.  (2022)  A novel umami electrochemical biosensor based on AuNPs@ZIF-8/Ti3C2 MXene immobilized T1R1-VFT.  FOOD CHEMISTRY,      [PMID:35944333] [10.1016/j.foodchem.2022.133838]

5. Jun Yang, Shulin Hu, Anqi Liao, Yetian Weng, Shuli Liang, Ying Lin.  (2022)  Preparation of freeze-dried bioluminescent bacteria and their application in the detection of acute toxicity of bisphenol A and heavy metals.  Food Science & Nutrition,  10  (6): (1841-1853).  [PMID:35702313] [10.1002/fsn3.2800]

6. Mengdi Wang, Zhuoran Zhang, Qingqing Huo, Maolong Wang, Yong Sun, Hongling Liu, Jing Chang, Bin He, Yan Liang.  (2022)  Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy.  ACS Applied Materials & Interfaces,      [PMID:35199981] [10.1021/acsami.1c22964]

7. Hui Chen, Han Zhang, Lixing Cao, Jinling Cui, Xuan Ma, Chong Zhao, Shutao Yin, Hongbo Hu.  (2022)  Glucose Limitation Sensitizes Cancer Cells to Selenite-Induced Cytotoxicity via SLC7A11-Mediated Redox Collapse.  Cancers,  14  (2): (345).  [PMID:35053507] [10.3390/cancers14020345]

8. Jieyao Yu, Yan Liu, Shaorong Zhang, Liyong Luo, Liang Zeng.  (2021)  Effect of brewing conditions on phytochemicals and sensory profiles of black tea infusions: A primary study on the effects of geraniol and β-ionone on taste perception of black tea infusions.  FOOD CHEMISTRY,      [PMID:33756321] [10.1016/j.foodchem.2021.129504]

9. Juan Yue, Li Li, Peng Miao, Zheng Wang, Zhimin Chang, Dan Shao, Haohua Shao, Qian Mei, Shi-zhong Luo, Wen-Fei Dong.  (2019)  One-step synthesis of acriflavine-based carbon dots for adenine detection and a theoretical study on the detection mechanism.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2019.04.041]

10. Yang Zhang, Ruixi Bai, Zhigang Zhao, Qiuxia Liao, Peng Chen, Wanghuan Guo, Chunqing Cai, Fan Yang.  (2019)  Highly selective and sensitive probes for the detection of Cr(VI) in aqueous solutions using diglycolic acid-functionalized Au nanoparticles.  RSC Advances,  9  (19): (10958-10965).  [PMID:35515295] [10.1039/C9RA00010K]

11. Huang Shuo, Zhong Ling, Li Shengnan, Liu Mingsheng, Zhang Zhao, Zhang Fengxiu, Zhang Guangxian.  (2019)  A novel monosodium-glutamate-based flame retardant containing phosphorus for cotton fabrics.  CELLULOSE,  26  (4): (2715-2728).  [PMID:] [10.1007/s10570-018-02241-8]

12. Dandan Yao, Lei Zhang, Jiaojiao Huang, Chenghong Sun, Yu Zhang, Xiaoli Gu, Chong-Zhi Wang, Fei Li, Lina Chen, Chun-Su Yuan.  (2018)  A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase–post synaptic density protein-95 uncouplers.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:29550707] [10.1016/j.jpba.2018.03.003]

13. Canghao Ni, Changqing Sun, Zhaofeng Zhou, Yongli Huang, Xinjuan Liu.  (2018)  Surface tension mediation by Na-based ionic polarization and acidic fragmentation: Inference of hypertension.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2018.02.113]

14. Jiaojiao Huang, Chenghong Sun, Dandan Yao, Chong-Zhi Wang, Lei Zhang, Yu Zhang, Lina Chen, Chun-Su Yuan.  (2018)  Novel surface imprinted magnetic mesoporous silica as artificial antibodies for efficient discovery and capture of candidate nNOS–PSD-95 uncouplers for stroke treatment.  Journal of Materials Chemistry B,  6  (10): (1531-1542).  [PMID:32254217] [10.1039/C7TB03044D]

15. Xiaoli Gu, Jiaojiao Huang, Lei Zhang, Yu Zhang, Chong-Zhi Wang, Chenghong Sun, Dandan Yao, Fei Li, Lina Chen, Chun-Su Yuan.  (2017)  Efficient discovery and capture of new neuronal nitric oxide synthase–postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies.  JOURNAL OF SEPARATION SCIENCE,  40  (17): (3522-3534).  [PMID:28704580] [10.1002/jssc.201700595]

16. Jingwen Lan, Yiming Gong, Baining Lin, Airong Xu, Rukuan Liu.  (2024)  Designing high performance hydrogel sensor for real-time sensing applications.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111272]

17. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui.  (2025)  Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40147642] [10.1016/j.ijbiomac.2025.142540]

18. Chen Yang, Kaikai Wei, Minghui Xu, Zhaojun Wang, Chuanjian Cui, Qianying Dai, Guijie Chen, Ruyan Hou.  (2025)  Sensory wheel construction and key flavor compounds characterization of black tea milk tea beverages.  FOOD CHEMISTRY,      [PMID:40147384] [10.1016/j.foodchem.2025.143931]

19. Wenshuai Zhou, Haoran Qin, Qian Zhang, Jiaqi Cai, Hetong Qi, Honglan Qi.  (2025)  Single-Site Iridium Catalyst on Metal–Organic Framework as Light-Responsive Oxidase-Like Nanozyme with High Stability for Colorimetric Detection of Antioxidant Capacity.  ANALYTICAL CHEMISTRY,      [PMID:40101180] [10.1021/acs.analchem.4c06063]

20. Xiao Zhang, Sihao Li, Heng Liu, Anurak Wongta, Zhenlin Xu, Kai Zhou, Surat Hongsibsong.  (2025)  Isolation and Characterizations of Histamine- and Tyramine-Producing Strains Isolated from Fermented Soybean Food: Soy Sauce and Soybean Paste.  Foods,  14  (14): (2407).  [PMID:40724227] [10.3390/foods14142407]

21. Yanjia Guo, Juan Lu, Wenzhuo Wang, Hanyue Jiang, Guangping Ma, Pengfei Han, Li Tian, Tengying Ma.  (2025)  Polymer donor PM6 assisted solid-state electrochemiluminescence sensor of copper-doped biomass carbon quantum dots for ultrasensitive detection of rhodamine B in chili powder.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115187]

22. Lifang Zou, Zhaoming Wang, Xingguang Chen, Shasha Zheng, Feiran Xu, Kezhou Cai, Hui Zhou, Guiran Xiao, Baocai Xu.  (2025)  Identification of transmembrane channel–like 4-targeting saltiness–enhancing peptides derived from chicken skin collagen and evaluation of their antioxidant abilities.  FOOD CHEMISTRY,      [PMID:40609341] [10.1016/j.foodchem.2025.145282]