L-Homocysteine - Moligand™, ≥95% , CAS No.6027-13-0

CAS: 6027-13-0 Cat. No.: L134501 Molecular Weight: 135.18 EC Number: 227-891-0

GRADE & PURITY Moligand™, ≥95%

Synonyms

Boronic acid, 1H-indol-4-yl- | DTXSID3041039 | AKOS006272166 | H-2800 | MFCD00151320 | 2-amino-4-sulfanylbutanoate | Hcy | NSC 43117 | 2-Amino-4-mercaptobutyric acid (VAN) | (2S)-2-amino-4-sulfanylbutanoic acid | I11579 | (s)-2-amino-4-mercaptobutanoic ac

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

L-Homocysteine is a homocysteine that has L configuration. Homocysteine is an essential intermediate in normal mammalian metabolism of methionine. L-Homocysteine induces upregulation of Cathepsin V that mediates vascular endothelial inflammation in hyperhomocysteinaemia.

Specifications

Synonyms

Boronic acid, 1H-indol-4-yl- | DTXSID3041039 | AKOS006272166 | H-2800 | MFCD00151320 | 2-amino-4-sulfanylbutanoate | Hcy | NSC 43117 | 2-Amino-4-mercaptobutyric acid (VAN) | (2S)-2-amino-4-sulfanylbutanoic acid | I11579 | (s)-2-amino-4-mercaptobutanoic ac

Specifications & Purity

Moligand™, ≥95%

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 504756071
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756071
• Canonical Smiles: C(CS)C(C(=O)O)N
• IUPAC Name: (2S)-2-amino-4-sulfanylbutanoic acid
• InChIKey: FFFHZYDWPBMWHY-VKHMYHEASA-N
• INCHI: 1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1
• Isomeric SMILES: C(CS)[C@@H](C(=O)O)N
• WGK Germany: 3
• Molecular Weight: 135.18
• Reaxy-Rn: 1721683
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1721683&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Thia fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Alkylthiols Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-alpha-amino acid - Thia fatty acid - Fatty acid - Fatty acyl - Amino acid - Alkylthiol - Carboxylic acid - Monocarboxylic acid or derivatives - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: Other amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

DDAH1 Tchem N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (231 Activities)

Discover Target: DDAH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (5%)
• Sensitivity: Moisture sensitive；Air sensitive；Heat sensitive
• Melt Point(°C): 232.5°C
• Molecular Weight: 135.190 g/mol
• XLogP3: -3.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 135.035 Da
• Monoisotopic Mass: 135.035 Da
• Topological Polar Surface Area: 64.300 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 86.100
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

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59. Chen Yanmei, Shang Xuefang, Li Congshu, Xue Zhenzhen, Chen Hongli, Wu Hongwei, Wang Tianyun.  (2018)  The synthesis, crystal, hydrogen sulfide detection and cell assement of novel chemsensors based on coumarin derivatives.  Scientific Reports,  8  (1): (1-9).  [PMID:30385799] [10.1038/s41598-018-34331-9]

60. Xiangqian Li, Zhan Zhou, Yiping Tang, Cheng Cheng Zhang, Yuhui Zheng, Jinwei Gao, Qianming Wang.  (2018)  Modulation of assembly and disassembly of a new tetraphenylethene based nanosensor for highly selective detection of hyaluronidase.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.08.093]

61. Shang Xuefang, Li Jie, Feng Yaqian, Chen Hongli, Guo Wei, Zhang Jinlian, Wang Tianyun, Xu Xiufang.  (2018)  Low-Cytotoxicity Fluorescent Probes Based on Anthracene Derivatives for Hydrogen Sulfide Detection.  Frontiers in Chemistry,      [PMID:29988478] [10.3389/fchem.2018.00202]

62. Chen Xuejiao, Gong Fuchun, Cao Zhong, Zou Wu, Gu Tingting.  (2018)  Highly cysteine-selective fluorescent nanoprobes based on ultrabright and directly synthesized carbon quantum dots.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  410  (12): (2961-2970).  [PMID:29523940] [10.1007/s00216-018-0980-3]

63. Siqi Li, Liuting Wang, Xiaodan Zhang, Hongxiang Chai, Yuming Huang.  (2018)  A Co,N co-doped hierarchically porous carbon hybrid as a highly efficient oxidase mimetic for glutathione detection.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2018.03.015]

64. Ya-Lan Wang, Quan-Fei Zhu, Li-Ming Cheng, Shao-Ting Wang, Shan-Shan Qin, Shu-Jian Zheng, Hua-Ming Xiao, Juan-Juan Li, Song-Mei Liu, Bi-Feng Yuan, Yu-Qi Feng.  (2018)  Stable isotope labeling - dispersive solid phase extraction - liquid chromatography - tandem mass spectrometry for quantitative analysis of transsulfuration pathway thiols in human serum.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:29518632] [10.1016/j.jchromb.2018.02.036]

65. Lili Chen, Hongliang Tan, Fugang Xu, Li Wang.  (2017)  Terbium (III) coordination polymer–copper (II) compound as fluorescent probe for time-resolved fluorescence ‘turn-on’ detection of hydrogen sulfide.  LUMINESCENCE,  33  (1): (161-167).  [PMID:28853233] [10.1002/bio.3386]

66. Juan He, Fujian Xu, Jing Hu, Shanling Wang, Xiandeng Hou, Zhou Long.  (2017)  Covalent triazine framework-1: A novel oxidase and peroxidase mimic.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2017.08.009]

67. Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng.  (2017)  Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.08.044]

68. Ru Li, Cuihua Lei, Xian-En Zhao, Yue Gao, Han Gao, Shuyun Zhu, Hua Wang.  (2017)  A label-free fluorimetric detection of biothiols based on the oxidase-like activity of Ag+ ions.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:28689074] [10.1016/j.saa.2017.06.056]

69. Wei Gu, Yinghan Yan, Xueyu Pei, Cuiling Zhang, Caiping Ding, Yuezhong Xian.  (2017)  Fluorescent black phosphorus quantum dots as label-free sensing probes for evaluation of acetylcholinesterase activity.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.05.017]

70. Zhijiao Tang, Zhenhua Lin, Gongke Li, Yuling Hu.  (2017)  Amino Nitrogen Quantum Dots-Based Nanoprobe for Fluorescence Detection and Imaging of Cysteine in Biological Samples.  ANALYTICAL CHEMISTRY,      [PMID:28266840] [10.1021/acs.analchem.7b00284]

71. Jin Peng, Xianfeng Hou, Fang Zeng, Shuizhu Wu.  (2017)  Fluorescent nanoprobe for in-vivo ratiometric imaging of endogenous hydrogen peroxide resulted from drug-induced organ damages.  BIOSENSORS & BIOELECTRONICS,      [PMID:28292734] [10.1016/j.bios.2017.03.003]

72. Jingjing Deng, Dingkun Lu, Xiaolei Zhang, Guoyue Shi, Tianshu Zhou.  (2017)  Highly sensitive GQDs-MnO2 based assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase fluctuation: A biomarker for organophosphorus pesticides poisoning and management.  ENVIRONMENTAL POLLUTION,      [PMID:28258856] [10.1016/j.envpol.2017.02.024]

73. Qin Wang, Shengrui Zhang, Yaogang Zhong, Xiao-Feng Yang, Zheng Li, Hua Li.  (2017)  Preparation of Yellow-Green-Emissive Carbon Dots and Their Application in Constructing a Fluorescent Turn-On Nanoprobe for Imaging of Selenol in Living Cells.  ANALYTICAL CHEMISTRY,      [PMID:28208245] [10.1021/acs.analchem.6b03983]

74. Lingzhi Zhao, Liu Zhao, Yanqing Miao, Chunye Liu, Chenxiao Zhang.  (2016)  Construction of a Turn Off-On-Off Fluorescent System Based on Competitive Coordination of Cu2+ between 6,7-Dihydroxycoumarin and Pyrophosphate Ion for Sensitive Assay of Pyrophosphatase Activity.  Journal of Analytical Methods in Chemistry,      [PMID:27766179] [10.1155/2016/4306838]

75. Yan Zhang, Jingjing Jiang, Min Li, Pengfei Gao, Ying Zhou, Guomei Zhang, Shaomin Shuang, Chuan Dong.  (2016)  Colorimetric sensor for cysteine in human urine based on novel gold nanoparticles.  TALANTA,      [PMID:27769441] [10.1016/j.talanta.2016.09.009]

76. Jiang Xue Dong, Xiao Fang Song, Yan Shi, Zhong Feng Gao, Bang Lin Li, Nian Bing Li, Hong Qun Luo.  (2016)  A potential fluorescent probe: Maillard reaction product from glutathione and ascorbic acid for rapid and label-free dual detection of Hg2+ and biothiols.  BIOSENSORS & BIOELECTRONICS,      [PMID:27015151] [10.1016/j.bios.2016.03.017]

77. Sihua Guo, Fangyuan Zheng, Fang Zeng, Shuizhu Wu.  (2015)  A fluorescent probe capable of discriminately and simultaneously detecting dl-dithiothreitol and single sulfhydryl-containing thiols.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2015.10.036]

78. Kai Jiang, Shan Sun, Ling Zhang, Yuhui Wang, Congzhong Cai, Hengwei Lin.  (2015)  Bright-Yellow-Emissive N-Doped Carbon Dots: Preparation, Cellular Imaging, and Bifunctional Sensing.  ACS Applied Materials & Interfaces,      [PMID:26426200] [10.1021/acsami.5b07255]

79. Qian Sihua, Lin Hengwei.  (2014)  A colorimetric indicator-displacement assay array for selective detection and identification of biological thiols.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  406  (7): (1903-1908).  [PMID:24442012] [10.1007/s00216-013-7591-9]

80. Xiaoqiang Cai, Jinhua Li, Zhong Zhang, Gang Wang, Xingliang Song, Jinmao You, Lingxin Chen.  (2013)  Chemodosimeter-based fluorescent detection of l-cysteine after extracted by molecularly imprinted polymers.  TALANTA,      [PMID:24468373] [10.1016/j.talanta.2013.12.019]

81. Hong-Qi Chen, Fei Yuan, Lun Wang.  (2013)  Simple and sensitive turn-on luminescent detection of biothiols based on energy transfer between green-emitting upconversion nanocrystals and gold nanoparticles.  Analytical Methods,  5  (11): (2873-2879).  [PMID:] [10.1039/C3AY40105G]

82. Gao Zihui, Wang Yuling, Ma Shuhui, Cao Juntao, Liu Yanming.  (2025)  A Photoelectrochemical Sensor for Glutathione Detection Based on a Target-triggered Etching Strategy.  Journal of Analysis and Testing,      [PMID:] [10.1007/s41664-024-00346-7]

83. Yidan Liang, Bo Han, Xiaokang Lu, Yuqi Zhang, Ji-Jiang Wang.  (2024)  A terphenyl derivative-based colorimetric-fluorimetric probe for the detection of lysine and arginine and their bioimaging.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:39374561] [10.1016/j.saa.2024.125230]

84. Zihan Wang, Yihong Chen, Zexian Chen, Jiarong Duan, Huiping Wang, Erhua Guo, Jianhui Zhi, Shaomin Shuang, Chuan Dong, Jun Li, Xiaojuan Gong.  (2025)  A trinity sensing platform for uric acid detection in clinical samples using Fe-functionalized carbon quantum dot nanozymes.  TALANTA,      [PMID:40164024] [10.1016/j.talanta.2025.128007]

85. Meng-Qi Wang, Ming-Xin Sun, Han-Guang Li, Ze-Hua Wu, Jian-Zhong Xu.  (2024)  Combining Protein Engineering and Pathway Engineering to Achieve Green Biosynthesis of l-Hypaphorine in Escherichia coli from Glucose.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.4c00640]

86. Chen Wang, Yuran Gui, Meihui Wu, Tong Wu, Haiping Wang, Wanxia Gao, Jiang Zheng, Na Zhao, Yibin Zhang, Xiji Shu, Jinting Shang.  (2024)  Design and characterization of a Near-Infrared Fluorescent Probe SCN for selective detection of Hydrogen Sulfide (H2S) in living systems and food samples.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2024.125522]

87. Jie Huang, Ruicheng Xu, Qiaoting Yang, Kang Tao, Dan Shan.  (2024)  Green one-step pyrolytic synthesis of folic acid-derived carbon dots for sensitive turn-on fluorescence detection of cysteine.  ANALYST,  149  (24): (5863-5870).  [PMID:39552241] [10.1039/D4AN01144A]

88. Shen Zhang, Jinlong Ma, Yangfan Wu, Jingwen Lu, Yuyu Guo.  (2024)  Histidine-capped copper nanoclusters for in situ amplified fluorescence monitoring of doxycycline through inner filter effect.  LUMINESCENCE,  39  (1): (e4677).  [PMID:38286601] [10.1002/bio.4677]

89. Yifei Xing, Song Shen, Zhenguang Wang.  (2024)  Modulating the intrinsic fluorescence properties of amoxicillin by sulfur nanodot-based nanoreactor for its direct fluorescence detection.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.156268]

90. Yan Su, Pengfei Gao, Guomei Zhang, Ying Zhou, Lihong Shi, Jianlin Wu, Wenting Liang, Shaomin Shuang, Yan Zhang.  (2024)  Multifunctional Au–Ag NCs for luminescence and colorimetric double signal sensing of H2S and catalytic reduction of nitrophenol.  TALANTA,      [PMID:39406086] [10.1016/j.talanta.2024.127022]

91. Yuanna Ning, Yongbo Wang, Shaojie Wang, Wencai Wang.  (2024)  One-component dual-mode sensor array for identification and quantification of biothiols.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:39647266] [10.1016/j.saa.2024.125555]

92. Siqi Wei, Renjie Li, Ling Li, Dan Huang, Li Wu, Xiandeng Hou.  (2024)  Photoinduced defective MIL-100-NH2 as SERS substrate with charge-transfer resonances for direct, sensitive and simultaneous detection of small-molecule biothiols.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.136076]

93. Wang Shulong, Li Zhifang, Xu Jiayao, Lin Qingyan, Huang Wenfang, Fan Mingzhu, Wang Rong, Luo Zhihui.  (2024)  Rational design of a near-infrared dual-emission fluorescent probe for ratiometric imaging of glutathione in cells.  MICROCHIMICA ACTA,  191  (2): (1-10).  [PMID:38217642] [10.1007/s00604-024-06179-6]

94. Lingyan Gui, Xu Teng, Ye Yang, Tao Liu, Yaru Liang, Jun Zeng, Xianying Zhang, Linhai Li.  (2025)  Real-time monitoring and multicolor visual analysis of hydrogen peroxide based on antenna effect-induced dual signal amplification strategy.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.137486]

95. Ying Xu, Cong Dai, Zhifeng Xu.  (2025)  Sensitive fluorescence turn-on sensing of hydroxyl radical and glucose based on the oxidative degradation of reductive organic cage.  TALANTA,      [PMID:39755078] [10.1016/j.talanta.2025.127518]

96. Biao Zhang, Jun Cao, Si-Jie Liao, Peng-Cheng Zhou, Yu-Ting Shen, Wei Yu, Wei Li, Ai-Guo Shen.  (2024)  Simultaneous SERS Sensing of Cysteine and Homocysteine in Blood Based on the CBT-Cys Click Reaction: Toward Precisive Diagnosis of Schizophrenia.  ANALYTICAL CHEMISTRY,      [PMID:38498948] [10.1021/acs.analchem.4c00395]

97. Xiabin Chen, Xiaoxuan Li, Huan Liu, Jianzhuang Yao, Yishuang Li, Hualing Li, Zelin Wu, Yun Zhang, Tingjun Hou, Jiye Wang, Shurong Hou.  (2025)  Discovery of a New Function of Human Butyrylcholinesterase and the Catalytic Activity of its Natural Variants toward Homocysteine Thiolactone Hydrolysis.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:40744384] [10.1016/j.cbi.2025.111683]

98. Qingling Nie, Ru Liu, Jiajia Liu, Yirong Xie, Yeting Tu, Ruiyun You, Yudong Lu, ChengLu Li, Zhenhua Liu, Jingbo Chen.  (2025)  SERS sensor based on carboxymethyl cellulose-silver hydrogel for dynamic detection of hydrogen sulfide in the inflammatory microenvironment.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.167705]

99. Yang Zhou, Yuxin Wei, Runqiu Wang, Yanli Wei, Li Wang.  (2025)  Fluorescent sensing system for the determination of L-Cys based on SQDs/MnO2 NS with a wide linear range.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114736]

100. Ying Xu, Cong Dai, Zhifeng Xu.  (2025)  Dual-channel ratiometric sensing of hypochlorous acid based on organic cage with red and green fluorescence.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:40945009] [10.1016/j.saa.2025.126928]

101. Xu Lixing, Du Xing, Liu Tianqing, Sun Dan.  (2023)  In situ and dynamic SERS monitoring of glutathione levels during cellular ferroptosis metabolism.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (25): (6145-6153).  [PMID:37644323] [10.1007/s00216-023-04909-y]

102. Dan Tang, Qin Wang, Shaojing Zhao, Jianing Yi, Minhuan Lan, Jie Zeng, Lei Huang.  (2023)  Environmental synthesis of yellow fluorescent carbon dots for on-off-on detection of mercury and cysteine.  INORGANIC CHEMISTRY COMMUNICATIONS,      [PMID:] [10.1016/j.inoche.2023.111160]

103. Jinjie Hou, Pei Jia, Kairong Yang, Tong Bu, Xinyu Sun, Li Wang.  (2021)  Facile preparation of Ru@V2O4 nanowires exhibiting excellent tetra-enzyme mimetic activities for sensitive colorimetric H2O2 and cysteine sensing.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.130266]

104. Fanyong Yan, Qianghua Ye, Jinxia Xu, Juanjuan He, Li Chen, Xuguang Zhou.  (2017)  Carbon dots-bromoacetyl bromide conjugates as fluorescence probe for the detection of glutathione over cysteine and homocysteine.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2017.05.050]

105. Mei Lin, Wei Bingjie, Liu Chunyan, Zhao Mengting, Cui Tian, Wei Xiangyang.  (2025)  Polyvinylpyrrolidone-stabilized ultra-small Fe3O4 nanoparticles-functionalized graphene oxide with synergistically enhanced peroxidase-like activity for glutathione colorimetric determination in rat serum.  MICROCHIMICA ACTA,  192  (4): (1-11).  [PMID:40131482] [10.1007/s00604-025-07044-w]

106. Zheng Wang, De-Man Han, Wen-Ping Jia, Qi-Zhong Zhou, Wei-Ping Deng.  (2012)  Reaction-Based Fluorescent Probe for Selective Discrimination of Thiophenols over Aliphaticthiols and Its Application in Water Samples.  ANALYTICAL CHEMISTRY,      [PMID:22536992] [10.1021/ac300512b]

107. Xu Xu, jing Li, Yaodong Zhang.  (2025)  Detection of blood glucose based on Aggregation induced luminescence effect in 4-formyl-3-hydroxybenzoic acid@ZIF-8 and Förster resonance energy transfer ratio fluorescence method between Aggregation-induced emission molecules and diallyl phthalate.  Analytical Methods,      [PMID:40528435] [10.1039/D4AY02325K]

108. Jiameng Pei, Lina Tang, Chenyang Kang, Fan Shi, Fengxia Liang, Yutao Li, Guo-Jun Zhang.  (2025)  Microneedle biosensor for real-time monitoring of hydrogen sulfide release from paraventricular nucleus of hypertension rats stimulated by electroacupuncture.  TALANTA,      [PMID:40311479] [10.1016/j.talanta.2025.128215]

109. Dan Li, Mao Li, Zijia Huang, Xiaolong Li, Xiaoming Chen, Na Li, Yong Zhao.  (2025)  Ultrasensitive, online detection of endogenous H2S by a novel ratiometric fluorescent approach.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.137874]

110. Qianqian Zhang, Shengping Han, Guican Deng, Xianzai Yan, Jiaxin Hong, Luying Duan, Guoqiang Wu, Yanping Hong, Lili Yu, Chunrong Wang.  (2025)  Surface-enhanced Raman spectroscopy based on 2,3-naphthalenedicarboxaldehyde derivative reagent for highly sensitive detection of cysteine and homocysteine.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:40378689] [10.1016/j.saa.2025.126395]

111. Xinyu Chen, Jinjin Liu, Zheng Tang, Shuangquan Liu, Jiayi Peng, Hao Liang, Xiangheng Niu.  (2025)  Machine Learning-Enabled Time-Resolved Nanozyme-Encoded Recognition of Endogenous Mercaptans for Disease Diagnosis.  ANALYTICAL CHEMISTRY,      [PMID:40340311] [10.1021/acs.analchem.5c01539]

112. Lihao Guo, Fengqi Zhang, Li Wang, Gandong Zhou, Youbin Zheng, Lei Ren, Zhe Wang, Jie Yin, Weiwei Wu, Miaomiao Yuan.  (2025)  Autonomous All-in-One Patch for Closed-Loop Diagnosis–Therapy of Melanoma.  ACS Sensors,      [PMID:40446214] [10.1021/acssensors.5c00791]

113. Meili Yang, Zuzhe Kang, Xinpei Zhong, Sirui Bai, Dong-En Wang, Qin Tu, Sheng Chen, Jinyi Wang, Mao-Sen Yuan.  (2025)  Visualizing GSH-ONOO− Redox and Tracking Lesion-Remedy of Acute Kidney Oxidative Injury Based on a Dual-Site Chemosensor.  Advanced Healthcare Materials,      [PMID:40424091] [10.1002/adhm.202500907]

114. Yin Yun-Dong, Zhang Yu-Wei, Song Xi-Tong, Hu Jun, Chen Yu-Heng, Lai Wen-Chuan, Li Ya-Fei, Gu Zhi-Yuan.  (2025)  Native globular ferritin nanopore sensor.  Nature Communications,  16  (1): (1-12).  [PMID:40481000] [10.1038/s41467-025-60322-2]

115. Sunying Yang, Jiaqi Cai, Liu Su, Jingxiao Huo, Huadong Xu, Yuhao Gu, Changhe Wang, Hetong Qi, Honglan Qi.  (2025)  Gold Disk Microelectrode Coupled Label-free Electrochemical Aptasensor for Dopamine Assay.  ANALYST,      [PMID:40557847] [10.1039/D5AN00511F]

116. Yu-Lan Zhang, Cheng-Xiao Deng, Jian-Mei Zou, Jia-Le Hu, Wei Li, Jin-Fang Nie, Yun Zhang.  (2025)  A fluorescence sensor array for biothiol detection and disease identification based on a CoOOH nanoflake triggered dual-color fluorescence system.  Analytical Methods,      [PMID:40504237] [10.1039/D5AY00472A]

117. Yuwen Liu, Wen Xu, Jing Li, Lu-Shuang Li.  (2025)  A novel carbon dots pair for the construction of a dual-channel fluorescent sensor array for discrimination and detection of biothiols.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:41308318] [10.1016/j.saa.2025.127255]

118. Ruru Chai, Jing Zeng, Alai Hailaxi, Yueling Song, Zhengchong Shen, Guixin Li.  (2025)  Construction of a Solvent Environment-Responsive AIECL Probe and Its Application in Electrochemiluminescence Sensing of Cysteine.  TALANTA,      [PMID:41455261] [10.1016/j.talanta.2025.129276]

119. Chi Yan, Xingyu Chen, Wenqing Gao, Chunlan Tang, Liwen Du, Chengyi Xie, Feng Xu, Keqi Tang, Jiancheng Yu.  (2025)  Chiral Derivatization Enables High-Resolution Ion Mobility Spectrometry of 30 Amino Acid Enantiomers.  ANALYTICAL CHEMISTRY,      [PMID:41451537] [10.1021/acs.analchem.5c06382]

120. Yang Yu Zhu, Li Gui Yong, Zhang Pu, Cui Linyun, Liu Huan Li, Chen Shi, Dai Xin.  (2026)  Construction of a ratiometric fluorescence sensor using Mahonia fortunei leaf-derived N-CDs and Eu3+ for smartphone-assisted portable and visual monitoring of tetracycline residues in food.  MICROCHIMICA ACTA,  193  (1): (60).  [PMID:41483208] [10.1007/s00604-025-07788-5]

121. Tongfang Chen, Jingjie Liang, Weiqing Liu, Fengxia Zhou, Chanci Qiu, Yuhui Peng, Xie Zhou.  (2026)  A Peptide-Functionalized Quantum Dots/MOF Nanosheets Fluorescence Biosensor for Glutathione Sensing and Cellular Imaging.  ANALYTICA CHIMICA ACTA,      [PMID:41663218] [10.1016/j.aca.2026.345120]

122. Xiang-Ling Qin, Hu-Dong Lv, Qi Yang, Bi-Xia Jin, Jing Ge, Ke-Xuan Wu, Jie-Ge Huo, Nan Yao, Song-Lin Li, He Zhu, Jing Zhou.  (2026)  Ethanol-precipitated Saccharides: Essential for Danggui Sini decoction against oxaliplatin-induced neurotoxicity.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:41611184] [10.1016/j.jep.2026.121275]

123. Jian Zhang, Qi Zhang, Jiaxin Li, Zhihong Zheng, Yanqing Miao, Chunye Liu.  (2026)  Dual-modified gold nanoparticles with nitrogen-doped carbon quantum dots and aspartic acid as response system: A paper-based fluorescence sensing platform for selective cysteine identification.  TALANTA,      [PMID:] [10.1016/j.talanta.2026.129710]