Latrepirdine dihydrochloride - ≥96% , CAS No.97657-92-6

CAS: 97657-92-6 Cat. No.: L129669 Molecular Weight: 392.37 EC Number: 692-160-9 PubChem CID: 23729232

GRADE & PURITY ≥96%

Synonyms

A915372 | 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole 2HCl | 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride | AS-59712 | GTWLIQOLGOZTLF-UHFFFAOYSA-N | Q27270139

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

A915372 | 2, 3, 4, 5-tetrahydro-2, 8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4, 3-b]indole 2HCl | 2, 8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3, 4-dihydro-1H-pyrido[4, 3-b]indole;dihydrochloride | AS-59712 | GTWLIQOLGOZTLF-UHFFFAOYSA-N | Q27270139

Specifications & Purity

≥96%

Biochemical and Physiological Mechanisms

Activator of AMPK, \xa0 potentiator of AMPA, and an inhibitor of L-type voltage-gated Ca2+ channels, NMDA receptors, H1/2 histamine receptors, α-adrenergic receptors, and 5-HT2C/5A/6 receptors. Displays neuroprotective and cognition enhancing effects in ne

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

• Pubchem Sid: 504769722
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504769722
• Canonical Smiles: CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl
• IUPAC Name: 2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole;dihydrochloride
• InChIKey: GTWLIQOLGOZTLF-UHFFFAOYSA-N
• INCHI: 1S/C21H25N3.2ClH/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H
• Isomeric SMILES: CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C.Cl.Cl
• PubChem CID: 23729232
• Molecular Weight: 392.37

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Indoles and derivatives
      • Subclass N-alkylindoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Indoles and derivatives
• Subclass: N-alkylindoles
• Intermediate Tree Nodes: Not available
• Direct Parent: N-alkylindoles
• Alternative Parents: 3-alkylindoles Methylpyridines Aralkylamines Substituted pyrroles Benzenoids Heteroaromatic compounds Trialkylamines Azacyclic compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-alkylindole - 3-alkylindole - Indole - Methylpyridine - Aralkylamine - Pyridine - Substituted pyrrole - Benzenoid - Pyrrole - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Amine - Organonitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO 24 mg/mL Water 79 mg/mL Ethanol 13 mg/mL
• Sensitivity: moisture sensitive
• Molecular Weight: 392.400 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 391.158 Da
• Monoisotopic Mass: 391.158 Da
• Topological Polar Surface Area: 21.100 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 425.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3