ASK1

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  1. CDK8/19-IN-1
    CAS: 1818427-07-4 PubChem CID: 126511854
    ◐ .Made to order · 8–12 wks Item #: C1424122
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    Technical Identifiers
    IUPAC Name
    8-[6-(2-methoxyethylcarbamoyl)pyridin-3-yl]oxy-4,5-dihydrothieno[3,4-g][1,2]benzothiazole-6-carboxamide
    SMILES
    COCCNC(=O)C1=NC=C(C=C1)OC2=C3C(=C(S2)C(=O)N)CCC4=C3SN=C4
    InChIKey
    NENJFZKQHYXRDQ-UHFFFAOYSA-N
    InChI
    1S/C19H18N4O4S2/c1-26-7-6-21-18(25)13-5-3-11(9-22-13)27-19-14-12(16(28-19)17(20)24)4-2-10-8-23-29-15(10)14/h3,5,8-9H,2,4,6-7H2,1H3,(H2,20,24)(H,21,25)
  2. CDK8/19-IN-1
    CAS: 1818427-07-4 PubChem CID: 126511854
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: C1494492
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  3. GDC-3280
    CAS: 1590403-33-0 Formula: C18H14F3N5O2 Molecular Weight: 389.33
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    ◐ .Made to order · 8–12 wks Item #: G1498426
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

How is the ASK1 listing put together?
It draws on reported ASK1 annotations within Apoptosis and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an ASK1 modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the ASK1 entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for ASK1 compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For ASK1 work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the ASK1 compound I need is not listed?
Search by CAS number or SMILES first, since analogs of ASK1 compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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