Antifolato

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  1. Levomefolate calcium
    CAS: 151533-22-1 Numero EC: 691-636-3 Formula: C20H23CaN7O6 Peso molecolare: 497.52
    Solido ≥95%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: L302964
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    calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
    SMILES
    CN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]
    InChIKey
    VWBBRFHSPXRJQD-QNTKWALQSA-L
    InChI
    1S/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,3show more
    Sinonimi
    CALCIUM L-5-METHYLTETRAHYDROFOLATE [DSC] | Rhenium, wire reel, 0.2m, diameter 0.076mm, annealed, 99.97% | BAY86-7660 ...
  2. Folinic acid, calcium salt pentahydrate
    CAS: 6035-45-6 Formula: C20H21CaN7O7.5H2O Peso molecolare: 601.59
    Solido ≥99%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: F304111
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    calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate
    SMILES
    C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]
    InChIKey
    NPPBLUASYYNAIG-ZIGBGYJWSA-L
    InChI
    1S/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-show more
    Sinonimi
    CALCII FOLINAS [WHO-IP LATIN] | 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (+)-, (Z)-2-b...
  3. 10-Formyl Folic Acid
    CAS: 134-05-4 Formula: C20H19N7O7 Peso molecolare: 469.41
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: F334434
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    (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
    SMILES
    C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C=O
    InChIKey
    UGWUWNVTCLDEOG-ZDUSSCGKSA-N
    InChI
    1S/C20H19N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,7,9,13H,5-6,8H2,(H,24,31)(H,show more
    Sinonimi
    10-Formylpteroylglutamic Acid | 10-Formyldihydropteroylglutamate | L-GLUTAMIC ACID, N-(4-(((2-AMINO-3,4-DIHYDRO-4-OXO...
  4. Pemetrexed, Inhibitor of dihydrofolate reductase;Inhibitor of phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide synthetase; phosphoribosylaminoimidazole synthetase;Inhibitor of thymidylate synthetase
    CAS: 137281-23-3 Numero EC: 680-625-9 Formula: C20H21N5O6 Peso molecolare: 427.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P125303
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    (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
    InChIKey
    WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
    InChI
    1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(show more
    Sinonimi
    GTPL5443 | N-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]phenyl}carbonyl)-L-glutamic acid...
  5. Pemetrexed, GAR transformylase inhibitor
    CAS: 150399-23-8 Formula: C20H19N5Na2O6 Peso molecolare: 471.37
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P129841
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    disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
    InChIKey
    NYDXNILOWQXUOF-GXKRWWSZSA-L
    InChI
    1S/C20H21N5O6.2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,2show more
    Sinonimi
    CAS-150399-23-8 | Pemetrexed Disodium is known as a Thymidylate synthase inhibitor. | PEMETREXED DISODIUM [USP MONOGR...
  6. Trimethoprim
    CAS: 738-70-5 Numero EC: 212-006-2 PubChem CID: 5578 Formula: C14H18N4O3 Peso molecolare: 290.32
    Solido Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: T129928
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    5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
    SMILES
    COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
    InChIKey
    IEDVJHCEMCRBQM-UHFFFAOYSA-N
    InChI
    1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
    Sinonimi
    5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine | Resprim | Bactoprim | Espectrin | Purbal | Roubal | Streptoplus | ...
  7. Pemetrexed disodium hydrate
    CAS: 357166-30-4 Numero EC: 604-733-2, 814-356-7 PubChem CID: 135564527 Formula: C20H21N5O6·5/2H2O·2Na Peso molecolare: 516.42
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P140269
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    tetrasodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;pentahydrate
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+show more
    InChIKey
    ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
    InChI
    1S/2C20H21N5O6.4Na.5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h2*1-2,4-5,9,13H,3,6-show more
    Sinonimi
    UNII-F4GSH45R4C | Pemetrexed accord | (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)be...
  8. Aminopterin Hydrate
    CAS: 54-62-6 Numero EC: 200-209-9 Formula: C19H20N8O5·xH2O Peso molecolare: 440.41(as Anhydrous)
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: A107171
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    (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
    SMILES
    Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
    InChIKey
    TVZGACDUOSZQKY-LBPRGKRZSA-N
    InChI
    1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(show more
    Sinonimi
    CAS-54-62-6 | Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-L(+)-glutamova | (2S)-2-[[4-[[(2,4-Diamin...
  9. Pralatrexate, Dihydrofolate reductase inhibitor
    CAS: 146464-95-1 Formula: C23H23N7O5 Peso molecolare: 477.47
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: P125726
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    (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid
    SMILES
    C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
    InChIKey
    OGSBUKJUDHAQEA-WMCAAGNKSA-N
    InChI
    1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,2show more
    Sinonimi
    (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid | CHEBI:39196 | (2S)-2-((4-...
  10. 7-Bromo-2,4-diaminoquinazoline
    CAS: 137553-43-6 Formula: C8H7BrN4 Peso molecolare: 239.07
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: B181364
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    7-bromoquinazoline-2,4-diamine
    SMILES
    C1=CC2=C(C=C1Br)N=C(N=C2N)N
    InChIKey
    YPWBLOIRVSSESG-UHFFFAOYSA-N
    InChI
    1S/C8H7BrN4/c9-4-1-2-5-6(3-4)12-8(11)13-7(5)10/h1-3H,(H4,10,11,12,13)
    Sinonimi
    DHFR-IN-3 | GS-4262 | 2,4-Quinazolinediamine, 7-bromo- | DTXSID20160236 | J-007040 | SY032047 | 7-Bromo-2,4-diaminoqu...
  11. Folinic acid calcium salt hydrate
    CAS: 1492-18-8 Formula: C20H21CaN7O7 · xH2O Peso molecolare: 511.50 (anhydrous basis)
    Solido ≥98%
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: F107310
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    calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
    SMILES
    [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
    InChIKey
    KVUAALJSMIVURS-ZEDZUCNESA-L
    InChI
    1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,show more
    Sinonimi
    AMPHOTERICIN B (USP-RS) | Calcii folinas | BUDESONIDE COMPONENT OF BREZTRI | Calcifolin | Folinac | Leucovorin calciu...
  12. Diaveridine
    CAS: 5355-16-8 Numero EC: 226-333-3 Formula: C13H16N4O2 Peso molecolare: 260.29
    ● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: D137262
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    5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
    SMILES
    COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC
    InChIKey
    LDBTVAXGKYIFHO-UHFFFAOYSA-N
    InChI
    1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
    Sinonimi
    CCG-213021 | 2, 5-[(3,4-dimethoxyphenyl)methyl]- | Diaveridina | EN300-7440332 | 5-[(3,4-dimethoxyphenyl)methyl]pyrim...
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Domande frequenti

How is the Antifolate listing put together?
It draws on reported Antifolate annotations within Cell Cycle/DNA Damage and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an Antifolate modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the Antifolate entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for Antifolate compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For Antifolate work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the Antifolate compound I need is not listed?
Search by CAS number or SMILES first, since analogs of Antifolate compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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