≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
LML134 is an orally active and highly selective inverse agonist of Histamine 3 receptor (H3R) with Ki of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg, respectively. LML134 has the potential for excessive sleep disorders.
| Canonical Smiles | CN1C(=O)C=CC(=N1)N2CCC(CC2)OC(=O)N3CCN(CC3)C4CCC4 |
|---|---|
| IUPAC Name | [1-(1-methyl-6-oxopyridazin-3-yl)piperidin-4-yl] 4-cyclobutylpiperazine-1-carboxylate |
| InChIKey | BVUJMFFRMZRNAT-UHFFFAOYSA-N |
| INCHI | 1S/C19H29N5O3/c1-21-18(25)6-5-17(20-21)23-9-7-16(8-10-23)27-19(26)24-13-11-22(12-14-24)15-3-2-4-15/h5-6,15-16H,2-4,7-14H2,1H3 |
| Isomeric SMILES | CN1C(=O)C=CC(=N1)N2CCC(CC2)OC(=O)N3CCN(CC3)C4CCC4 |
| Molecular Weight | 375.47 |
| Reaxy-Rn | 26571678 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26571678&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Diazinanes |
| Subclass | Piperazines |
| Intermediate Tree Nodes | Piperazine carboxylic acids and derivatives |
| Direct Parent | Piperazine carboxylic acids |
| Alternative Parents | Dialkylarylamines Pyridazinones N-alkylpiperazines Aminopyridazines Piperidines Imidolactams Heteroaromatic compounds Carbamate esters Trialkylamines Lactams Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Piperazine-1-carboxylic acid - Dialkylarylamine - Aminopyridazine - Pyridazinone - N-alkylpiperazine - Piperidine - Pyridazine - Imidolactam - Heteroaromatic compound - Carbamic acid ester - Lactam - Tertiary amine - Tertiary aliphatic amine - Azacycle - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Amine - Carbonyl group - Organic nitrogen compound - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as piperazine carboxylic acids. These are heterocyclic compounds containing a piperazine ring substituted by one or more carboxylic acid groups. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2426634 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426635 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426636 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426637 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426638 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426639 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426640 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| B2426641 | Certificate of Analysis | Jan 18, 2024 | L412557 |
| Molecular Weight | 375.500 g/mol |
|---|---|
| XLogP3 | 0.600 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 375.227 Da |
| Monoisotopic Mass | 375.227 Da |
| Topological Polar Surface Area | 68.700 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 629.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
