≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Mofegiline hydrochloride (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and amine oxidase, copper containing 3 (AOC3) or vascular adhesion protein 1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride demonstrates a time dependent irreversible inhibition of SSAO. In rat studies, Mofegiline hydrochloride showed preferential inhibition of brain MAO-B with ED50 values of 8 and 0.18 mg/kg p.o. for the A and B forms, respectively. In anaesthetized rats, Mofegiline hydrochloride did not significantly potentiate tyramine effects on the cardiovascular system. Mofegiline hydrochloride was studied and extensively researched as a potential treatment of Parkinson′s disease and Alzheimer′s disease, but was never marketed.
| Canonical Smiles | C1=CC(=CC=C1CCC(=CF)CN)F.Cl |
|---|---|
| IUPAC Name | (2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine;hydrochloride |
| InChIKey | QUCNNQHLIHGBIA-HCUGZAAXSA-N |
| INCHI | 1S/C11H13F2N.ClH/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9;/h3-7H,1-2,8,14H2;1H/b10-7+; |
| Isomeric SMILES | C1=CC(=CC=C1CC/C(=C\F)/CN)F.Cl |
| PubChem CID | 6446650 |
| Molecular Weight | 233.69 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Phenylbutylamines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylbutylamines |
| Alternative Parents | Fluorobenzenes Aryl fluorides Vinyl fluorides Fluoroalkenes Organofluorides Monoalkylamines Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenylbutylamine - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Fluoroalkene - Haloalkene - Vinyl fluoride - Vinyl halide - Organonitrogen compound - Organofluoride - Organohalogen compound - Primary aliphatic amine - Amine - Hydrochloride - Primary amine - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylbutylamines. These are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Sensitivity | Moisture sensitive |
|---|---|
| Boil Point(°C) | 322.7° C at 760 mmHg (Predicted) |
| Molecular Weight | 233.680 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 233.078 Da |
| Monoisotopic Mass | 233.078 Da |
| Topological Polar Surface Area | 26.000 Ų |
| Heavy Atom Count | 15 |
| Formal Charge | 0 |
| Complexity | 184.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 2 |
